Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"signaling intermediates"”.
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
… stimulated genes (ISGs). In the absence of key signaling intermediates of the PI-3'K/mTOR pathway, namely, Akt or PI-3'K, an IFN-α/β inducible antiviral response was abolished. Given the apparent importance of this pathway, we sought to enhance IFN-α/β signaling by targeting key negative …
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Actin Regulatory Dynamics Required for T Cell Activation: A Quantitative and Systems-Level Perspective
… antigen-presenting cell (APC). Upon activation, signaling ensues with the coordination of dozens of diverse signaling molecules in space and time, a feature of cell signaling we call ‘spatiotemporal patterning’. We performed a systems-scale analysis of the spatiotemporal patterning of T cell …
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Analysis of signal transduction networking using activation ratios
… Previously developed methods for analyzing signaling networks have been largely ignored, most likely due to their mathematical complexity and difficulty in application. A novel analysis framework was developed to assist in the examination of signaling networks, both to facilitate the …
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Application of High-Performance Liquid-Chromatography Mass-Spectrometry Platform to Study Metabolism and Epigenetic Control of Metabolism
… occurring small molecules (metabolites, signaling intermediates) are a critical component of the information flow in biology, along with DNA, RNA, and proteins. Metabolomics is an analytical approach that seeks to comprehensively analyze naturally occurring small molecules and quantify …
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Common Signaling Elements in Response Pathways Activated by the Endothelial Survival Factors VEGF and Insulin
… Thus, crosstalk between VEGF and insulin signaling may occur at numerous points. Our objectives were twofold: 1) to characterize the combined effects of insulin and VEGF on downstream elements, and 2) to determine the ability of signaling intermediates principally associated with either …
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The Role of Mir-34A In Inhibition of Prostate Tumor Growth In The Bone and Induction of Autophagy
… from constitutive activation of compensatory signaling pathways. This dissertation work focused on a mechanistic understanding of how cross talk between tyrosine kinase receptors contributes to therapy resistance, and how this may be overcome by downregulating expression of these receptors. In …