Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"signaling inhibition"”.
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FGF signaling in Xenopus laevis lens regeneration
… examines the relationship between FGF signaling and lens regeneration, exploring the hypothesis that the FGF signaling plays a key role in triggering lens regeneration. First, the mRNA expression levels of FGFs and FGFRs in the cornea and retina were observed, as the key ligand from the …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… from our group have shown that blocking solTNF signaling at the time of a unilateral 6-OHDA striatal lesion attenuated behavioral deficits and the acute loss of dopaminergic neuron loss by 50%. However, a critical question of clinical relevance is whether delayed solTNF signaling inhibition can …
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Role of Notch Signaling in T Cell Polarization
… naïve CD4+ T cells, I have shown that Notch signaling, particularly Notch1, plays a crucial role in Th17 polarization. By using pharmacological inhibitors and specific knockdown of Notch1, I have shown that Notch1 is necessary for Th17 differentiation. Furthermore, IL-17 promoter assays and …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
… and an EGFR inhibitor. Genetic ablation or inhibition of EGFR decreased keratinocyte proliferation and resulted in epidermal hypoplasia. EGFR regulated keratinocyte progression through multiple cell cycle checkpoints. In vivo, EGFR controlled keratinocyte progression through the Gi to …
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Influence of Indole and Mixed Culture Growth on Pseudomonas Aeruginosa Biofilm Structure
When microorganisms are studied within their natural environments, they are not commonly found as single species. Microbes are usually found as clusters or multitudes of aggregates within surface-attached biofilm communities. The discovery of this sessile lifestyle has had a resounding effect on …