Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"signaling crosstalk"”.
-
Signaling crosstalk in cancers
Deregulation of cellular signaling contributes to the malignant phenotype of cancer. In this dissertation, cross-talk among oncogenic signaling pathways was investigated in two common human cancers. \r\n Pancreatic cancer has a well known spectrum of genetic alterations, among which KRAS mutation …
-
Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… are triggered by marked elevation of RAS/MAPK signaling and progression from benign papilloma to invasive malignancy. A subset of tumor-initiating basal progenitors, the cancer stem cells, obtain increased resistance to chemo and immunotherapy along this path. However, the distribution and …
-
Caffeine Binding Non-Canonical Biased Adenosine A₂AR GPCR Modulates Neu1 Activation and Signaling in Breast Cancer Cells
Dysregulated receptor signaling networks contribute to breast cancer progression and metastatic plasticity, particularly in triple-negative breast cancer (TNBC), an aggressive subtype with limited therapeutic options. Among these signaling systems, the adenosine A₂A receptor (A₂AR), a G …
-
Elucidating the role of the EGFR-family members in cell motility through the use of novel engineered bivalent ligands
… commonly upregulated in NSCLC cells, and their signaling crosstalk can confer therapy resistance. The four EGFR-family members are similar in structure; each contains a ligand binding domain, a transmembrane region, and a phosphotyrosine cytosolic domain. Upon ligand binding, each of the family …
-
Systems Biology Study of Breast Cancer Endocrine Response and Resistance
… can wisely choose and switch between different signaling programs according to their differentiation stages and external environments. Cancer cells can hijack this plasticity to develop drug resistance. For example, breast cancers that are initially responsive to endocrine therapy often develop …
-
The Cell Membrane Proteome of the SKBR3/HER2+ Cells and Implications for Cancer Targeted Therapies
… proteins and receptors and/or by alternative signaling pathways that cross-talk with- or transactivate HER2+ triggered signaling. This study was aimed at investigating the cell membrane proteome of SKBR3 cells, representative of HER2+ breast cancers, and the signaling landscape and cellular …
-
Crosstalk Between Calcium Signaling and Lipid Metabolism at Endoplasmic Reticulum-Plasma Membrane Junctions
Receptor-induced Ca2+ signaling is the key to many cellular functions, such as secretion, migration, differentiation, and proliferation. The increase in cytosolic Ca2+ signals is dependent on the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) at the plasma membrane (PM). To enable …
-
Temporal Transcriptional Regulation of IL-10-Induced Anti-Inflammatory Genes in LPS-Triggered Macrophages
… in a manner that depends on synergy with TLR signaling (referred to as IL-10 super-induced genes). IL-10 induces the expression of these target genes in three distinct temporal waves - first, primary response genes, followed by early secondary response genes, and then late secondary response …