Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 5766 for “"signaling"”.
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Central signaling pathways in chemotactic signaling
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Glia-neuron signaling
<p>This dissertation deals with release of neurotransmitter from glia. It has been demonstrated that bradykinin causes a receptor-mediated release of excitatory amino acids (EAAs), glutamate and aspartate, from glial cultures obtained from dorsal root ganglia (DRG) together with an increase in the …
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Signaling crosstalk in cancers
Deregulation of cellular signaling contributes to the malignant phenotype of cancer. In this dissertation, cross-talk among oncogenic signaling pathways was investigated in two common human cancers. \r\n Pancreatic cancer has a well known spectrum of genetic alterations, among which KRAS mutation …
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Mechanisms of TRAF Signaling
… activity, and are coupled to intracellular signaling cascades by TNFR associated factor (TRAF) proteins, which are cytoplasmic adaptor molecules. The roles of TRAF1, TRAF2, and TRAF6 are investigated structurally and functionally in the activation of NF-κB, AP-1, and Src-family kinases. Cbl …
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Estrogen signaling during decidualization
… in embryo resorption. To identify the downstream signaling pathway(s) and molecular candidate(s) that mediate the action of local E, we performed gene expression profiling, using decidual tissues obtained from mice treated with or without letrozole, a specific inhibitor to the key biosynthetic …
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Liquidity facilities and signaling
This dissertation studies the role of signaling concerns in discouraging access to liquidity facilities like the IMF contingent credit lines (CCL) and the Discount Window (DW). In Chapter 1, I analyze the introduction of IMF CCL in an economy with asymmetric information and financial frictions. …
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Dividend Signaling and Sustainability
Since the 1970s, dividends have not only become less common (Fama and French, 2001), they have become less sticky, too. Today, it is not uncommon for a firm to cease dividend payments within three years of initiation. I examine the differences between firms that continue to pay dividends for a long …
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Understanding Host Antiviral Signaling Pathways
… detect virally-derived nucleic acids and trigger signaling pathways which lead to the activation of transcription factors like nuclear factor-kappa B (NF-kappa B), interferon regulatory factor 3 (IRF3) and interferon regulatory factor 7 (IRF7). These transcription factors regulate the synthesis of …
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Lipid Signaling Under Microgravity Conditions
… This response involves a complex interplay among signaling molecules, most of which are represented by endogenous bioactive lipids such as endocannabinoids, sphingolipids, eicosanoids, and specialized pro-resolving mediators (SPMs). Each signal plays a role in different phases of the inflammatory …
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Metabolic Regulation of Cellular Signaling
… we tested the ability of aberrant glucose signaling to regulate the CaM-binding protein PI3K. We found that addition of G6P, mimicking aberrant glucose metabolism, or CoA to X. laevis egg extracts activated Akt in a phosphatidylinositol 3-kinase (PI3K), phosphoinositidedependent protein …
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Morphogenetic signaling in growing tissues
… size and patterning of tissues are ensured by signaling molecules as e.g. morphogens. Secreted from a restricted source, morphogens spread into the adjacent target tissue where they form a graded concentration profile. Upon binding of the morphogens to receptors on the cell surfaces, the …
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Estrogen Signaling in Trigeminal Nociception
Migraine is much more common in women than in men, and painful episodes are linked to the hormonal fluctuations of the menstrual cycle. The MAP kinase extracellular-signal regulated kinase (ERK) is activated in experimental models of chronic pain, and is also activated by estrogen in sensory …
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Molecular mechanisms of KRas4b signaling
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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The localization of mTORC1 signaling
… activity levels and localizations of key signaling proteins. In eukaryotic cells, cell size is increasingly appreciated as being coordinated by the Target of Rapamycin (TOR) Pathway. TOR is a serine/threonine kinase that resides in two distinct protein complexes which in mammals are …
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Signaling at the neuromuscular synapse
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Social signaling in decision making
… A subset of these features, the social signaling measurements, are very useful when analyzing and quantifying conversation. The goal of this thesis is to better understand the framework of social signaling. We applied the social signaling measurements to negotiations as well as to small …
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Serotonin signaling in C. elegans
… in genes that encode proteins important for 5-HT signaling, like the 5-HT receptor encoded by mod-1 and the Ga subunit of a G protein encoded by goa-1. This ability to suppress indicates that these genes likely act downstream of or in parallel to one or more 5-HT synapse(s) that mediate(s) the …
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Modularity of signaling cycle architectures
… is thus important in understanding their role in signaling systems in the cell, as well as to design modular units in synthetic biology. In this work, these systems are treated as input-output systems, and singular perturbation methods based on their fast time-scale of operation are used to …
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Molecular Regulation of Opioid Receptor Signaling
… receptors (KOR) are mediated through different signaling cascades. KOR activation of G protein-dependent signaling results in analgesia, whereas the dysphoric effects are mediated by a different pathway involving G protein-coupled receptor kinase (GRK) and arrestin. Therefore, a partial KOR …
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