Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 135 for “"signal transduction pathways"”.
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Engineering Signal Transduction Pathways in Bacteria
… in biologischen Stoffwechselwegen, z.B. in der Signalweiterleitung, vorzunehmen. Dieses könnte die Grundlage für viele Anwendungen sein, z.B. in der Gentherapie um neue Eigenschaften in Organismen einzuführen. Viele biologische Prozesse sind einem hohen Rauschpegel unterworfen, was für viele …
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Insulin and TSH signal transduction pathways in human preadipocytes.
Signaling through the rapamycin-sensitive mammalian target of rapamycin-p70 S6 kinase (p70 S6K) pathway was examined in human preadipocytes in primary culture. The inhibitory effect of rapamycin on insulin-induced differentiation of preadipose cell lines has been attributed to a blockade of clonal …
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Signal transduction pathways involved in skeletal muscle fibre type regulation
… were to further investigate and define the signal transduction pathways implicated in the control of skeletal muscle fibre phenotype. The ability of a fast muscle to undergo a transition towards a slower phenotype in response to chronic low-frequency stimulation (CLFS) was assessed, via …
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PMCA as a regulator of calcium/calmodulin-dependent signal transduction pathways
… have discovered that it may play a novel role in signal transduction pathways. It was the aim of this work to further characterise and confirm the role PMCA plays in regulating calcium/calmodulin-dependent signal transduction pathways. PMCA4 has already been shown to inhibit the NFAT family of …
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Lateral Membrane Domains Organize and Regulate Components of Signal Transduction Pathways
… of the mitogen activated protein kinase (MAPK) signaling cascade also localized into domains in vesicles containing acidic lipids. The formation of lateral membrane domains induced by Ki-Ras 4B and the Raf-cysteine rich domain (Raf-CRD) was inhibited by the anti-tumor agent farnesylthiosalicylic …
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Inferring Signal Transduction Pathways from Gene Expression Data using Prior Knowledge
… developmental stimuli. These stimuli trigger signal transduction pathways in plants, leading to cellular adaptation. A signal transduction pathway is a network of entities that interact with one another in response to given stimulus. Such participating entities control and affect gene …
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Exploring Parkinson’s disease associated LRRK2 and PINK1/Parkin signal transduction pathways within immune cells
… They both encode protein kinases, which control signal transduction pathways through reversible phosphorylation of target proteins3. Current research aims to better understand and visualise the activation of both proteins and their associated pathways, to help uncover their role in PD …
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Pharmacological Studies of the Signal Transduction Pathways of the a 1a-Adrenbrgic Receptor Subtype
… and mitogen activated protein kinase (MAPR) pathways. In some systems, the adenylyl cyclase pathway, including adenosine 3',5'-cyclic monophosphate (cAMP) and protein kinase A (PRA), inhibits activation of extracellular-signal regulated kinase 1/2 (ERR 1/2). However, interaction among these …
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Analysis of signal transduction pathways and the cytoskeleton in VASP-deficient cell lines and mouse models
… formation and cell spreading, I analyzed this signalling pathway in VASP-/- cells stimulated with Platelet Derived Growth Factor-BB (PDGF-BB) or fetal calf serum. In wild type cells Rac and Pak were rapidly and transiently activated by PDGF or serum; however, in the absence of VASP both Rac and …
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Genetic analysis of cGMP-dependent chemosensory signal transduction pathways in the detection of bacterial metabolites by C. elegans
The ability of metazoans to sense and interpret the external chemical environment is conferred by the chemosensory nervous system governing the senses of smell and taste. Chemosensory neurons convey external stimuli in the form of electrical impulses, as well as by changes in gene expression. This …
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URSOLIC ACID INHIBITED PROLIFERATION AND INVASION OF MDA-MB-231 HUMAN BREAST CANCER CELLS VIA REGULATING CELLULAR SIGNAL TRANSDUCTION PATHWAYS
… breast cancer cells via regulating cellular signal transduction pathways. Specific objectives are designed as: a) to investigate anti-proliferation and anti-invasion effects of UA in MDA-MB-231 human breast cancer cells; b) To determine specific molecular targets of UA on cellular signal …
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Programming and reprogramming cellular identity
… cells must respond to external cues, and signal transduction pathways converge on gene regulatory machinery to shape cellular identity. The work presented here focuses on the mechanisms by which transcription factors, chromatin regulators, miRNAs and signal transduction pathways …
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The cloning of calmodulincDNAs from barley and Arabidopsis and expression of barley calmodulin in transgenic tobacco
… to play a pivotal role in modulating biochemical pathways in conjunction with transient calcium fluxes into the cytoplasm. In order to better understand calcium-regulated signal transduction pathways in plants at the molecular level, cDNA sequences of CaM and CaM-like proteins were cloned and …
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Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion
… cell adhesion to the ECM triggers a series of signal transduction pathways that involve calcium mobilization, focal adhesion kinase (FAK) activation, and downstream events leading to alteration of cell function manifested by migration and matrix metal loproteinase (MMP) production. Our working …
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Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models
… include disturbances in intracellular signaling and ongoing injury with oxidative stress, inflammation, and lipotoxicity. The major signal transduction pathways affected in both degenerative and neoplastic disease states in liver include: insulin/IGF, Wnt/β-catenin, and others.
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Genotoxic effects of nano and bulk forms of aspirin and ibuprofen on blood samples from prostate cancer patients compared to those from healthy individuals: The protective effects of NSAIDs against oxidative damage, quantification of DNA repair capacity and major signal transduction pathways in lymphocytes from healthy individuals and prostate cancer patients
… the role of NSAIDs on some key regulatory signal transduction pathways in isolated lymphocyte cells was investigated by studying their effect on ataxia-telangiectasia-mutated kinase (ATM) and ataxia-telangiectasia and Rad3-related kinase (ATR) mRNA. ATM mRNA significantly increased after …
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Influence of the Atrial Natriuretic Peptide on TNF- αα α -activated human endothelial cells
… work. figure 1 summary: schematic diagram of the signal transduction pathways clarified by the first section of the present work It has been shown before that TNF- increases the expression of cell adhesion molecules E-selectin and ICAM-1 via activation of the transcription factor NF- B. We could …
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