Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 866 for “"signal transduction"”.
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4-1BB-Mediated signal transduction
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Engineering Signal Transduction Pathways in Bacteria
… in biologischen Stoffwechselwegen, z.B. in der Signalweiterleitung, vorzunehmen. Dieses könnte die Grundlage für viele Anwendungen sein, z.B. in der Gentherapie um neue Eigenschaften in Organismen einzuführen. Viele biologische Prozesse sind einem hohen Rauschpegel unterworfen, was für viele …
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Regulation of signal transduction by RGS4
… of proteins called Regulators of G protein Signalling (RGS) was investigated. A C-terminal fluorescent tag on RGS4 confirmed that transiently transfected RGS4 was predominantly cytosolic and underwent translocation to the plasma membrane of HEK293T cells following co-expression of Gi1, the …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… ligand used to identify CLEC-2 receptor and it’s signaling on platelets. In the first chapter we identified a new agonist for CLEC-2 receptor. Fucoidan, a sulfated polysaccharide from fucus vesiculosus, decreases bleeding time and clotting time in hemophilia, possibly through inhibition of tissue …
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Signal transduction via multiple BMP receptor complexes
… and tissue homeostasis. Ligand mediated signal transduction is transmitted via BMP type I and BMP type II receptors, both members of the serine/threonine kinase superfamily. The BMP receptor mediated signal transduction is not explored in detail. Therefore our aim was to address different …
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Scaffold-Mediated Organization of Signal Transduction Networks
… Raf-MEK-ERK kinase cascade is a highly conserved signal transduction module involved in cellular processes ranging from proliferation and differentiation to transformation and apoptosis, and is engaged in response to growth factors, cytokines, morphogens, and other extracellular stimuli. Given the …
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HEDGEHOG SIGNAL TRANSDUCTION IN EFFECTOR IMMUNE CELLS
Hedgehog (Hh) signalling is a classical morphogen pathway that regulates key processes in embryonic development, adult tissue homeostasis, and tumorigenesis. Recently, the Hh pathway has also been shown to be critical for CD8+ and CD4+ effector functions, acting in a cell-autonomous manner and …
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Resolving Signal Transduction in Complex Biological Environments
… such as cancer, diabetes and paralysis. While signal transduction has been understood at a great detail for ion channels and G-protein coupled receptors (GPCRs), transmembrane signaling in enzyme-linked receptors have so far remained elusive due to the presence of only a single transmembrane …
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A microscopic model of signal transduction mechanisms: olfaction
… - receptor recognition processes, and thus signal transduction, is not fully understood to the highest level of scientifc explanation and prediction. One such example of this is olfaction. Molecules cannot necessarily be predicted from a smell, and similarly a smell from molecules. Better …
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Stochastic dynamics in olfactory signal transduction and development
… the first two stages of the olfactory sense: the signal transduction inside the cilia of the olfactory receptor neurons and the first 'relay station' in the brain, the olfactory bulb, as well as the connection between these two. Theoretical studies that classify the experimentally achieved …
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Mathematical modelling of negative feedback signal transduction processes
… in cells are controlled by extracellular signals which are caused by many different chemical signals from their surrounding. Cells have the capability to react to signal transduction in an appropriate way, such as activate the response of intracellular molecules, which is mainly governed …
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Signal Transduction Mechanisms Of Pas And Hamp Domains
The focus of my dissertation is on the signaling mechanisms employed by PAS and HAMP domains, which are widespread signaling modules that coordinate cellular metabolism with external stimuli. A subset of PAS domains directly sense external stimuli, through an associated cofactor or ligand, and …
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Molecular mechanisms of signal transduction in neutrophil chemotaxis
… orchestrated steps. Recently the underlying signaling mechanisms of neutrophil chemotaxis are better understood with the studies in knockout mice and neutrophil-like cell lines: a number of signaling molecules in neutrophil chemotaxis have been identified, and a feedback loop-based model of …
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Alternative signal transduction for functional nucleic acid sensors
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Cellular compartmentation effects in receptor-mediated signal transduction
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1999.
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Analysis of signal transduction networking using activation ratios
… and distributed within a cell are termed signal transduction. These pathways allow cells to interact with each other and with their environments and are critical to the proper cellular function in a variety of contexts. Previously developed methods for analyzing signaling networks have …
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Analysis and Interpretation of Complex Biological Signal Transduction Networks
Cellular signaling is a complex system of biological communication that coordinates cellular activities via biochemical reactions. The passing of an extracellular signal across a cell membrane to intracellular signaling molecules is referred to as signal transduction. Signals transduced across a …
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The CD23 receptor-regulation of expression and signal transduction
… nahe, dass die beiden Isoformen zwei getrennte Signalübertragungswege miteinander verbinden. Die Gegenüberstellung von Ereignissen, welche in Zellen, die nur eine einer oder beide Isoformen von CD23 besitzen, stattfinden, legt die Vermutung nahe, dass CD23b cAMP und iNOS hochreguliert, …
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Insulin and TSH signal transduction pathways in human preadipocytes.
Signaling through the rapamycin-sensitive mammalian target of rapamycin-p70 S6 kinase (p70 S6K) pathway was examined in human preadipocytes in primary culture. The inhibitory effect of rapamycin on insulin-induced differentiation of preadipose cell lines has been attributed to a blockade of clonal …
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Targeting Opioid Receptor Signal Transduction to Produce Sustained Analgesia
… affecting reward by exploiting differential MOP signalling mechanisms in the pain and reward pathways. MOPs, delta opioid receptors (DOPs) and β-arrestin2 (BAR2) are all necessary components of the signalling complex in nociceptive neurones for morphine analgesic tolerance; c-Src (a tyrosine …
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