Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"signal transducer and activator of transcription"”.
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The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning
… tumor necrosis factor alpha (TNFα) but the signalling pathways involved still remain unclear.
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The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological postconditioning
Includes abstract. Includes bibliographical references (leaves 131-147).
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
<p>The JAK-STAT pathway is a major signaling pathway involved in many biological processes including proliferation, apoptosis, and differentiation. Aberrant expression of STATs has been reported in multiple human cancers and murine mouse models of tumorigenesis. Previous studies from our lab and …
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Signal Transducer and Activator of transcription-1 (STAT-1) und STAT-1 assoziierte Proteine (MCM3,MCM5) in epithelialen Ovarialkarzinomen : Expressionsanalysen und Prognostische Relevanz
… ist trotz Fortschritte in der Diagnostik und Behandlung mit ca. 20-25% gering. Die Identifizierung molekularer Prognosemarker könnte verbesserte und individualisierte Therapieprotokolle ermöglichen. Ziel dieser Studie war es, die mRNA und Proteinexpression von „signal transducer and activator of …
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Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection
High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the transcription factor signal transducer and activator …
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Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries
… 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal transducer and …
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The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection
Moderate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-α) and the signal transducer and activator of …
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Testing metabolic and pharmacological agents for recovery following de novo acute heart failure in an isolated rat heart model
… an isolated rat heart model, we established and validated a model of de novo acute heart failure to study novel putative cardio protective therapies against acute heart failure, including glucose, insulin and the molecular agent sphingosine-1-phosphate(component of high density lipoprotein) …
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Potential oxygen-dependent regulation of PIAS3
Protein inhibitor of activated STAT3 (PIAS3), a regulator of the JAK/STAT pathway, binds to and blocks the DNA-binding activity of signal transducer and activator of transcription 3 (STAT3). PIAS3 has the potential to be hydroxylated at a specific proline residue, in an amino acid sequence known to …
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Sumo-Specific Protease 1 Controls Lymphoid Development Through Regulation of Sumoylation/Acetylation Switch In Stat5
… systems, but the physiological functions of SENPs are poorly understood. STAT5 (Signal Transducer and Activator of Transcription 5) plays a critical role in the development of lymphoid cells. However, it is not known whether STAT5 is regulated by the SUMOylation pathway. Here, we showed …
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Neuroprotective effects of incretin mimetics upon chronic endoplasmic reticulum (ER) stress : implications for novel therapeutic pathways and opportunities in Alzheimer's disease
… that incretin mimetics exert neuroprotective and neurorestorative effects across a range of experimental models of neuronal degeneration. In a recent pilot clinical trial, Liraglutide rescued the decline of the cerebral glucose consumption in Alzheimer’s disease (AD) patients, signifying …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 bei der Interleukin 6 vermittelten Akutphase - Genregulation und T-Zell-Migration
Stimulation of the IL-6R complex leads to activation of the Jak/STAT (Januskinase/Signal Transducer and Activator of Transcription)-pathway and the Ras/Raf/MAPK-cascade. The protein tyrosine phosphatase SHP2 (SH2 - containing tyrosine phosphatase) is recruited to gp130, the signaltransducing …
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Bedeutung der IL-6-Signaltransduktionsinhibitoren SHP2 und SOCS3 für die Desensitisierung des IL-6-Signalweges
The immediate early response of cells treated with IL-6 (interleukin-6) is the activation of the signal transducer and activator of transcription (STAT) 3. The Src homology domain 2 (SH2)-containing protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3 (suppressor of cytokine …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
CD4 T helper cells control immunity to pathogens and the development of inflammatory disease by acquiring the ability to secrete effector cytokines. Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu by activating Signal Transducer and …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
"Cholesterols are enriched in the brain and can be oxidized to oxysterols by spontaneous or enzyme-mediated processes. Oxysterols are transport forms of cholesterols across cell membranes and the blood-brain barrier. Here, to elucidate the roles of oxysterols in brain inflammation, I treated …
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Local regulation of increased milk yield due to early lactation increased milking frequency
… in yield is locally regulated within the gland; however the mechanism for the increase in yield is unknown. The objective of this study was to demonstrate a difference in milk and component yield, both during the IMF period and throughout the remainder of lactation, and examine potential …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… responsible for controlling adaptive immunity and tolerance. Recently, type I cDCs (cDC1s) have been delineated as a distinct cDC subset, uniquely responsible for coordinating T cell-mediated immunity against pathogens and tumors. Although the importance of cDC1s is now well established, the …
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Identification of novel components in fibroblast growth factor signalling
… many roles in development, cell proliferation and differentiation. They possess intrinsic tyrosine kinase activity which enables activation of other signalling proteins, formation of multiprotein signalling complexes and activation of downstream cascades. The goal of this project was to …
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