Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"signal peptidase"”.
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Parallel effects of signal peptide hydrophobic core modifications on cotranslational translocation and posttranslational cleavage by purified signal peptidase
… amino terminal extension sequence known as the signal peptide. Signal peptides contain a central core of uncharged amino acids that are usually hydrophobic in nature. The hydrophobic core of the parathyroid hormone (PTH) signal peptide is composed of 12 contiguous hydrophobic amino acids. …
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Assembly and Display of Surface Proteins In Actinomyces Oris
… <p>Cell wall-anchored proteins contain a signal peptide to direct their secretion to the exoplasmic side of the membrane, where they are liberated from the secretion machine by signal peptidases. Cell wall-anchored proteins also contain a cell wall sorting signal, which is required for …
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Archaeal signal peptides and cell surface structures
… unfold. Integral to this process are the various signal peptidases. Two types of archaeal signal peptidases are identified thus far: signal peptidase I (SPI) and the preflagellin peptidase. SPI is responsible for processing the majority of secreted proteins. Sequence analysis of archaeal SPI …
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Understanding the role of TapA in the formation of <i>B. subtilis</i> biofilms: a biochemical and genetic analysis
… been demonstrated to involve the action of the signal peptidase SipW with the tapA-sipW-tasA genes found together on the B. subtilis genome.<br/><br/>Recent work from Erskine et al has demonstrated that TasA fibres (fTasA) form spontaneously in vitro (Erskine et al., 2018). The findings of this …
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An in vitro chemogenomic screening system to identify the molecular targets of antimalarial drug candidates
… elucidated a possible novel target, the parasite signal peptidase enzyme *sec11*. While downstream validation experiments were unable to confirm whether *sec11* was indeed the target for its interacting compound, it could represent a promising druggable target in the parasite warranting further …
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Characterization of the glycosylation and signal peptide sequences within the vaccinia virus m2 protein and influence on ERK1/2 and NF-kB activation
… M2 amino acid sequence revealed an N-terminal signal peptide sequence, 4 putative glycosylation residues, and endoplasmic reticulum (ER) retention/retrieval sequences, indicative of an ER-localized protein. Confocal microscopy analysis confirmed localization of M2 to the ER. It was found that …
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Apolipoprotein M – Studies of Structure and Function
… Mature apoM is circulating with a retained signal peptide. By constructing apoM with a cleavable signal peptide we were able to show that the signal peptide is necessary for the protein’s ability to associate to lipoproteins. We were also able to show that, in contrast to apoM with a …