Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"siglec"”.
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Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
<p>Sialic acid binding Ig-like lectin-7 (Siglec-7), expressed primarily on NK cells,<br/> binds preferentially to alpha2,8 linked disialic acids such as present in the<br/> ganglioside GD3 that is upregulated in certain cancers. Siglec-7 is classified as<br/> an inhibitory receptor as it contains …
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Lymphodepletion with repeated cycles of alemtuzumab and secondary autoimmunity after alemtuzumab treatment of relapsing-remitting multiple sclerosis
… described as suppressive via interaction with Siglec-10, in the mechanism of secondary autoimmunity, and determine the biomarker potential of pre-treatment cytokine levels. Findings: CD4 and CD8 lymphocytes are less effectively depleted with repeated treatment cycles. Lymphocyte surface CD52 …
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Investigating the antibody-independent functions of B lymphocytes
… attract inflammatory monocytes. The absence of Siglec-G, an inhibitory receptor expressed in innate B1a cells, exacerbates AKI in murine models. Conversely, concomitant administration of a Siglec-G agonist, sialic acid (Neu5AC), ameliorated AKI and reduced renal neutrophil infiltration. These …
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Investigating the phenotype and function of tissue-resident B cells in mouse and human non-lymphoid organs
… modified mice with higher (PI3Kδ E1020K-B, Siglec-G-/-) or lower (μMT-) numbers of tissue-resident B cells in NLOs, we tested the function of these cells in the context of urinary tract infection. The number of tissue-resident B cells inversely correlated with bacterial clearance suggesting …
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Verwendung von Gene-Targeting-Techniken zur Etablierung neuer Mauslinien mit Mutationen in B-Zell-Signalwegen
… Oberflächenprotein CD22, einem Mitglied der Siglec (Sialinsäure bindende Igähnliche Lektine) Proteinfamilie. Dieses Transmembranprotein besitzt sieben extrazelluläre Immunoglobulin-ähnliche Domänen und kann über die äußerste V-set Domäne seine Liganden: α2,6 verknüpfte Sialinsäuren binden. …
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Regulation of Protective B cell Anti-Tumor Responses
… a sialic acid-binding, Ig-like, lectin receptor (Siglec), and was found to significantly suppress antigen-specific antibody responses to mucins bearing sialylated TACAs. Inhibition of CD22 binding of sialic acids using monoclonal antibody blockade during immunization significantly increased …
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Investigating the role of Sialoadhesin in Influenza A virus infection
… One such Sia receptor is sialoadhesin (Sn, Siglec-1, CD169), a major macrophage receptor that preferentially recognizes terminal Sia in specific linkages to underlying sugars. Studies on the functions of Sn have demonstrated a role in mediating cell-cell interactions with the innate and …
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Investigating the susceptibility of foreskin myeloid cells to ex vivo HIV infection
… and the mannose receptor, DC-SIGN and Siglec-1 as HIV attachment factors and (iii) Investigating the HIV susceptibility of foreskin epidermal cells using an optimised ex vivo pluricellular foreskin infection model of suspension cells. Methodology: Foreskin specimen were obtained from 60 …
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CD33 and TREM2 regulation of microglial functions
… sialic acid-binding immunoglobulin-type lectin (Siglec) in both mice and human microglial cells. Knock down of CD33 in a mouse microglial cell line, BV-2, resulted in increased phagocytosis of several targets and increased migration towards ATP. Human CD33 has two distinct variants: CD33M, …
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Development of versatile drug delivery strategies using PLGA nanoparticles
… N- Acetyl-neuraminic acid (o2-8-NANA) to target siglec receptors expressed on immune cells as the basis of a novel anti-inflammatory therapy to treat acute lung injury and the more severe acute respiratory distress syndrome. 02-8-NANA conjugated NP demonstrated RAW 264.7 monocyte cell targeting …
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Phagosome proteomes in activated macrophages
… receptors such as mannose receptor 1 and Siglec-1. Moreover, BMDM phagosomes mature considerably faster when validated using fluorogenic phagosome function assays. <br/>For the main goal of my project, I have performed a thorough proteomics analysis of the phagosome proteomes of …
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Role of Neuraminidase-mediated Desialylation in Microglial Activation
… by desialylation of TLR4 and disruption of Siglec-E:TLR4 binding. As for the phagocytic response, sialidase treatment of microglial cells increased phagocytosis in vitro. Knockdown or inhibition of CD11b, a component of the pro-phagocytic receptor complement receptor 3 (CR3), effectively …
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Generierung von chimären Mäusen mit Mutationen in der Signalleitungs-Domäne von CD22 und Untersuchungen zur Funktion von CD22 in Knockout-Mäusen
… B-Zell spezifischen Transmembran-Rezeptor der Siglec-Familie (Sialinsäure-bindende Immunglobulin-ähnliche Lectine). Mit der äußersten der 7 extrazellulären Ig-ähnlichen Domänen kann CD22 spezifisch mit a2,6-Sialinsäure interagieren. In der cytoplasmatischen Domäne von CD22 befinden sich 6 …
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Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin
The porcine reproductive and respiratory syndrome virus (PRRSV) causes the economically most important viral disease in swine industry today. The virus is a major threat to swine health worldwide, since it is both associated with the porcine respiratory disease complex and the cause of severe …