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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"siderophores"”.
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Detection of mycobacterial siderophores and implications for diagnostics
… of Mtb and to accomplish this it produces siderophores called mycobactins and carboxymycobactins. This dissertation has sought to build a simple assay for detection and quantification of mycobacterial siderophores that has potential applications in tuberculosis (TB) diagnosis. This assay …
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Iron limitation and the role of siderophores in marine Synechococcus
… oligotrophic cyanobacteria lack iron-binding siderophores that are present in many heterotrophic marine bacteria. Siderophores are widely distributed in the surface ocean and compose an important portion of the pool of natural ligands that bind >99% of all soluble Fe. In bottle incubations …
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Iron limitation and the role of Siderophores in marine Synechococcus
… oligotrophic cyanobacteria lack iron-binding siderophores that are present in many heterotrophic marine bacteria. Siderophores are widely distributed in the surface ocean and compose an important portion of the pool of natural ligands that bind >99% of all soluble Fe. In bottle incubations …
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Characterization of arsenic-binding siderophores from environmental bacteria and evaluation of their role in arsenic tolerance
… tolerance mechanisms include the production of siderophores, metabolites with chelating activity that can decrease the toxicity of metals and metalloids. Although a correlation between siderophore production and metalloid tolerance has been described, the structure of arsenic-binding …
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Siderophore cycling in the North Pacific Subtropical Gyre
… some heterotrophic bacteria are able to produce siderophores, which are small organic ligands with extraordinarily high stability constant for Fe(III), to facilitate Fe uptake. The recently developed mass spectrometry based techniques allow for the characterization and quantification of …
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Characterization of a Catechol-Type Siderophore and the Detection of a Possible Outer Membrane Receptor Protein from <em>Rhizobium leguminosarum</em> strain IARI 312.
… gram-negative bacteria produce and secrete siderophores under iron-deficient conditions. Siderophores are low molecular weight compounds (600-1500 Daltons), which chelate ferric iron with an extremely high affinity, and the complex is actively transported across the outer and inner membranes …
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Isolation of a Siderophore Produced by Methicillin-Resistant <em>Staphylococcus aureus</em> Strain H372.
… overcome these limitations bacteria have evolved siderophores. Siderophores are low molecular weight compounds that bind ferric iron with a high affinity. <em>Staphylococcus aureus</em> is an important human pathogen that is known to produce at least four siderophores, and these siderophores …
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Isolation and Identification of the Siderophore "Vicibactin" Produced by <em>Rhizobium leguminosarum</em> ATCC 14479.
<p>Siderophores are small, iron chelating molecules produced by many bacteria to help meet the iron requirements of the cell. Multiple metabolic functions require iron as it serves as a cofactor in many enzymes and cellular processes. However, in the presence of oxygen and at physiologic pH, iron …
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Isolation, Purification, and Chemical Characterization of the Dihydroxamate-Type Siderophore, "Schizokinen," Produced by <em>Rhizobium leguminosarum</em> IARI 917.
… Many bacteria have the ability to produce siderophores, low molecular weight compounds that have a high affinity for Fe<sup>3+</sup>. Siderophores are part of a multi-component system that actively transports the iron-siderophore complex into the cytoplasm. Rhizobia are characterized by …
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Utilization of ferrioxamine microarrays for the rapid detection of pathogenic bacteria
<p>Siderophores are low-molecular weight species utilized by bacteria for the sequestration of iron, an essential nutrient. Siderophores and their cognate receptors are considered to be virulence factors, due to their prominent role in pathogenicity. The work presented here focuses on ferrioxamine …
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Rhizosphere competence, antibiotic and siderophore biosynthesis in Pseudomonas chlororaphis: implications for the biological control of cotton seedling disease pathogens
… synthesized by soilborne pseudomonads, siderophores (sid) (low molecular weight Fe⁺³ chelators) and antibiotics (ant), in the suppression of these pathogens. Greenhouse bioassays to screen for rhizosphere competent strains identified a single strain of Pseudomonas chlororaphis (L-850), …
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Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
Chapter 1. Introduction to Iron Homeostasis and Siderophores Iron is an essential nutrient for almost all living organisms. This Chapter presents an overview of iron homeostasis in human and bacteria, as well as the biology and chemistry of siderophores and siderophore conjugates. Siderophores are …
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Mechanistic Studies and Inhibition of N-hydroxylating Monooxygenases
… in the biosynthesis of hydroxamate containing siderophores. Siderophores are high affinity iron-chelators composed of catechol and hydroxamate functional groups that are synthesized and secreted by several microorganisms and plants. It has been showed that many NMOs are essential for virulence …
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Siderophore-Based Drug Repurposing of Platinum Anticancer Agents as Targeted Antibiotics and Investigation of Pt-Induced DNA Damage in Gram-Negative Bacteria
… targeted antibacterial activity by leveraging siderophores, secondary metabolites utilized by bacteria to acquire the essential transition metal nutrient iron (Fe). This SAC approach exploits the molecular recognition between siderophores and their cognate transport machinery, hijacking …
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Siderophore production by heterotrophic bacterial isolates from the Costa Rica Upwelling Dome
… of iron in the ocean. Despite the importance of siderophores in the environment, only limited information from a select group of bacteria is available. On a cruise through the Costa Rica Dome (CRD) upwelling region in July 2005, a library of 867 isolates from five depth profiles inside and …
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Siderophore production by heterotrophic bacterial isolates from the Costa Rica upwelling dome
… of iron in the ocean. Despite the importance of siderophores in the environment, only limited information from a select group of bacteria is available. On a cruise through the Costa Rica Dome (CRD) upwelling region in July 2005, a library of 867 isolates from five depth profiles inside and …
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The synthesis and biological evaluation of a library of autoinducer-antibiotic conjugates
… has shown promise in initial studies. Siderophores are used by bacteria for iron uptake, and so attaching antibiotics to them allows the antibiotic to be carried across cell membranes. This study investigated conjugates designed using a similar approach, but using bacterial autoinducers …
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INSIGHTS INTO THE METAL HANDLING MECHANISMS OF TITANIUM DIOXIDE-BINDING BACTERIA RHODOCOCCUS RUBER
… sophisticated mechanisms to acquire it. Siderophores are small, metalchelators secreted by bacteria that scavenge iron and bring it to the organism for its metabolic needs. The significance of this class of molecules is that they can be used in the pharmaceutical industry for delivering a …
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Molecular determination of marine iron ligands by mass spectrometry
… and were dominated by amphibactins, amphiphilic siderophores that partition into cell membranes. Furthermore, synechobactins were detected within nepheloid layers along the continental shelf. These siderophores reflect adaptations that impact dissolved iron bioavailability and thus have important …
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Exploring the Evolution of Pathogenicity in a Mult-host Bacterial Pathogen Using Comparative Genomics
… history of siderophore gene clusters in Pantoea. Siderophores are noted virulence factors involved in iron acquisition; however, the siderophore complement of Pantoea has been largely unexplored. Through comparative genomic and phylogenetic analyses, biosynthetic gene clusters for three distinct …
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