Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"sidechain"”.
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Influence of Sidechain Structure and Interactions on the Physical Properties of Perfluorinated Ionomers
… dissertation was to investigate the influence of sidechain structure and sidechain content on the morphology and physical properties of perfluorosulfonic acid ionomer (PFSA) membranes. One of the primary objectives was to characterize the thermomechanical relaxations for short sidechain PFSAs …
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In silico tools for the development of biotherapeutics
… of the amide bond, relative orientation of the sidechain, and the availability of the sidechain. These four factors impact the first two steps of the hydrolysis mechanism: the addition of the proton to the peptide bond and the addition of the sidechain to the peptide backbone. The secondary …
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Secure and scalable blockchain mechanisms for IoT applications
… within blockchain-based IoT networks using a sidechain-based trust and access control system, named sidechain-based trust and access control mechanism for IoT networks (SATI). By distributing trust evaluation and access control operations across a separate blockchain or sidechain, SATI …
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Single-conformation spectroscopy of hydrogen bonding networks: Solvation, synthetic foldamers, and neurodegenerative diseases
… its flexible, hydrogen bond forming sidechain—is intimately involved with neurodegenerative diseases such as Huntington’s disease. Single-conformation studies help reveal the delicate interplay between three different types of hydrogen bonds within the molecule: backbone-backbone, …
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NMR, Crystallographic and Quantum Chemical Studies of Amino Acids in Peptides and Proteins
… we can predict the back-bone torsion angles and sidechain conformation with accuracy of 5.8 degrees by using Z-surface approaching. Second we extended our investigations to compute sidechain C13 a of aliphatic and aromatic amino acid, such as Ile, Trp and His, both in peptides and protein. The …
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Molecular modeling of DNA with minor groove binding agents and intercalators
… favorable interaction energy. It threads its sidechain through the DNA so that while the planar aromatic ring system stacks between base pairs, there is one sidechain in the major groove and one in the minor groove. These extra interactions between the drug and DNA help the interaction to be …
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Electrostatic properties at the interface of p53 Transactivation domain binding
… IDPs. We observed large relative change in sidechain dipole moments when comparing the p53 TAD alone and when bound to either CBP or MDM2. We observed that aliphatic and aromatic amino acids experienced the largest relative change in sidechain dipole moments, and that there is sensitivity to …
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The Role of Force-Sensitive Interactions in Amyloid Assembly by Fungal Adhesins
… which can layer onto other adhesin β-sheets by sidechain–sidechain interactions to form highly stable amyloid fibrils. The Als (agglutinin-like sequence) proteins are one type of the amyloid fibril-forming adhesin that decorates the cell wall of C. albicans and have been implicated in …
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Analysis and Error Correction in Structures of Macromolecular Interiors and Interfaces
… automatic correction of errors in protein sidechain rotamers. </p><p>My study of protein--protein interfaces identifies amino acid pairing preferences in a set of 146 transient interfaces. Using a geometric interface surface definition devoid of arbitrary cutoffs common to previous studies …
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Blockchain-Based Distributed Network Architecture for Internet of Things
… the resource consumption. We propose a novel sidechain structure via optimized two-way peg protocol for device authentication in the smart community in order to overcome the limitations of existing authentication approaches. The proposed sidechain structure requires the mainchain mining nodes …
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Fluorination of Rubisco-Mimetic CO2 Capture Systems. Theoretical and Experimental Studies of Ammonium Ion Acidity Depression and Carbamylation
… tetrapeptide sequence Lys-Asp-Asp-Glu. The Lys sidechain amine undergoes carbamylation and an Mg<sup>2+</sup> cation stabilizes the resulting carbamate. The N<sup>a</sup>-acyl-lysinyl-aspratyl-aspartyl-glutamide (Lys-Asp-Asp-Glu, KDDE) peptide featured maximum capture at pH ≈ 10; a pH region too …
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A Deuterium Nuclear Magnetic Resonance Study of Amino Acid Dynamics in the Membrane Protein, Bacteriorhodopsin (Nmr)
… crystal lattice effects on the mobility of the sidechain. Similar sidechain mobility, (tau) and (DELTA)E('(DBLDAG)) measurements are reported for these amino acid sidechains within bacteriorhodopsin. Overall, our results demonstrate a similarity between the dynamics in amino acid crystals and in …
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Poly(Phenylene vinylene) And Poly(Naphthalene vinylene) Derivatives for Use in Organic Light-Emitting Diodes (OLEDs)
… The role of oxygen in the solubilizing sidechains of conjugated polymers was investigated. When oxygen is removed from these sidechains, the solubility and device performance are adversely affected. Incorporation of oxygen in the chain in a position further from the aromatic ring …
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Ontwikkeling van spirocyclische vitamine D3 analoga met potentiële dissociatie van biologische activiteiten
… compound. Next, the nor‐A‐ring and the sidechain are attached. Also a variety of sidechains is tested on their influence on the biological activity. (1) R. Bouillon, W.H. Okamura, Norman, A.W. Endocr. Rev. 1995, 16, 200‐257; (2) W. Schepens et al. Org. Lett. 2006, 8, 4247‐4250; (3) G.‐D. …
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Voltage-dependent gating at the selectivity filter of the MthK K+ channel.
… residues (TVGYG). Within this sequence, the sidechain of the conserved threonine residue determines the entry to the selectivity filter, and may thus be a key regulator of the K+ conduction cycle. Interestingly, the rapidly inactivating voltage-gated K+ channel, HERG, contains a serine at …
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MULTIPLE STRATEGIES IN COMPUTATIONAL PROTEIN DESIGN: STRUCTURAL INTUITION, PROBABILISTIC INVERSE FOLDING, AND GENERATIVE APPROACHES
… design problem—from backbone geometry and sidechain packing to supramolecular assembly and functional site engineering.
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Design and synthesis of cyclometalated transition metal complexes as functional phosphorescent materials
… Col(h) liquid crystals with only one sidechain. Furthermore, the combined liquid crystalline and mechanochromic properties make them attractive functional materials.
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Crystallographic studies of the metal-responsive transcription factor NikR
… coordination by three histidines and a cysteine sidechain. A structure of NikR in complex with a 30 base-pair oligonucleotide containing the nik operator sequence illustrates the dramatic conformational changes associated with DNA binding, shows the nature of the specific and non-specific …
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Fundamental aspects of the chrome tanning reaction
… which indicated preferred reaction at aspartate sidechain carboxyls. This is supported by chrome tanning studies following treatment of collagen by amidase enzymes. Geometric details of chromium(lll) species involved in the tanning reaction were elucidated by extended X-ray absorption fine …
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