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Showing 1 to 7 of 7 for “"sialoadhesin"”.
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Investigating the role of Sialoadhesin in Influenza A virus infection
… interactions. One such Sia receptor is sialoadhesin (Sn, Siglec-1, CD169), a major macrophage receptor that preferentially recognizes terminal Sia in specific linkages to underlying sugars. Studies on the functions of Sn have demonstrated a role in mediating cell-cell interactions with …
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Sialoadhesin is not required for infection of pigs with PRRSV-1
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin
… identified the macrophage-specific protein sialoadhesin as an important entry receptor for PRRSV. In addition, it was shown that sialylated glycans on the virion surface are crucial for the infectivity of the virus towards macrophages. However, the exact nature of the interaction between the …
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An investigation of the regulation of Sialoadhesin ligands on CD4+ T cells and its potential significance in Systemic Lupus Erythematosus
Sialoadhesin (Sn) is the prototype of Sialic acid binding Immunoglobulin-Like Lectins(SIGLECs). Sn is expressed on macrophages from metalophilic zone and subcapsular sinus in spleen and lymph nodes respectively. Under inflammatory conditions, Sn expression is upregulated on macrophages. Sn was …
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Development of Novel Macrophage Imaging Agents
… and 99mTc-ED3 targeting the antigen sialoadhesin and 1111n-DTPA-ED2 targeting CD163, of which both antigens are macrophage-restricted. All the agents described herein exhibit tracking to endogenous sialoadhesin-expressing macrophage populations with exceptionally fast blood clearance …
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Pathogenic impact of immune-related cells in Batten disease
… Juvenile NCL mouse models with mice deficient in sialoadhesin (Sn), a binding protein found on macrophages and microglia, and is involved in pro-inflammatory T-cell regulation. Disease progression was also slowed down, with significantly increased neuron survival in both Sn deficient NCL mice. …