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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 8 of 8 for “"siRNA therapeutics"”.

  1. Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis

    Zhao, ZhenUniversity of Missouri -- Kansas City2018

    … systems to deliver small interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and liver fibrosis. siRNAs targeting vascular endothelial growth factor (VEGF) and IκB kinase ε (IKBKE) were used for treating TNBC, while siRNA targeting poly(rC) binding protein 2 …

    umkc Repository record

  2. Explorations of siRNA therapeutics using molecular dynamics simulations: structural impacts of 2'-ribose modifications on RNA duplex and interactions with human Argonaute-2

    Tajudeen, Ridwan O., University of Lethbridge. Faculty of Arts and Sciences2025

    lethbridge

  3. Mouse Models of Inherited Skin Diseases

    Fu, Dun JackUniversity of Dundee2014

    … mutant KRT9 allele with short interfering RNAs (siRNAs) was explored as a potential therapeutic approach. This led to the development and in vitro validation of potent mutation- and gene-specific siRNA inhibitors. <br/>Despite its importance in EPPK, little is known about the physical requirement …

    dundee Repository record

  4. Tumor-penetrating delivery of small interfering RNA therapeutics

    Ren, Yin, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2012

    … "delivery" challenge, as small interfering RNA (siRNA) therapeutics must overcome clearance mechanisms and penetrate into tumor tissues to access cancer cells. This thesis sought to develop nanotechnology-based platforms to rapidly discover and validate cancer targets in vivo. First, we developed …

    mit Repository record

  5. Multifunctional Chemical Cross-linkers for Drug Carriers and Molecular Probes

    Walker, Joshua AaronCornell University2019

    … vesicles and quantify endosomal escape for siRNA therapeutics. Taken together, these works highlight the importance of chemical cross-linkers in the design of multifunctional bioconjugates for a variety of applications.

    cornell Repository record

  6. Development and characterization of chemical modifications for siRNA strand selection

    Varley, Andrew JamesUniversity of Ontario Institute of Technology2021

    Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects one of the two strands as a guide to form the RNA induced silencing complex …

    uoit Repository record

  7. Engineering multimodal nanoparticles to combat triple-negative breast cancer

    Hoover, Elise C.University of Delaware2025

    … compared to other subtypes. Many current chemotherapeutics used to treat TNBC are nonspecific, and, therefore, cause off-target effects and fail to elicit a robust tumor response, which results in higher mortality and recurrence rates. Targeted therapy enabled by nanoparticle (NP)-based drug …

    udel Repository record

  8. RNA Therapeutics for Fibrolamellar Hepatocellular Carcinoma

    Neumayer, Christoph2026

    … to synthesize small interfering RNAs (siRNAs) with state-of-the-art chemical modifications. Multiple siRNA therapeutics targeting genes in the liver have been FDA approved. The majority of these use a carbohydrate group, GalNAc, that binds to the asialoglycoprotein receptor (ASGR), …

    rockefeller Repository record