Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"siRNA duplexes"”.
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The synthesis and in vitro evaluation of siRNAs modified at the backbone with a novel triazole-based internucleotide linkage and abasic alkyl-chain linkages of varying length
… use of double-stranded short interfering RNAs (siRNAs) to silence the expression of genes associated with disease at the translational level has gained much attention. Using a highly conserved endogenous pathway within cells, siRNA technology displays a high degree of target specificity and …
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Synthesis, characterization and biological investigation of self-delivering and modified short interfering RNAs (siRNAs)
… mRNA. Synthetic short interfering RNAs (siRNAs) can use this endogenous machinery and have emerged as a novel class of gene-silencing therapeutics. Unfortunately, the development of RNAi therapeutics has been hindered by several challenges associated with the nature and structure of RNA. …
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The Mechanism of RNA Interference in Neurospora
… (RNAi) pathway, small-interfering RNA (siRNA) duplexes generated by Dicer are incorporated into the RNA-induced-silencing complex (RISC), and subsequently converted to single-stranded siRNA. Generation of single stranded siRNA is a pre-requisite for recognition and cleavage of the target …
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The conjugation and evaluation of hydrophobic small molecules to trazole-linked siRNAs
… therapies, such as short interfering RNAs (siRNAs), have been developed to aid in the regulation of proteins. SiRNAs serve as substrates for the highly conserved RNA interference (RNAi) pathway, which gives rise to their high degree of mRNA target specificity and their catalytic nature. …