Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"short-term plasticity"”.
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Molecular Mechanisms of Presynaptic Plasticity and Function in the Mammalian Brain
Synaptic plasticity describes efficacy changes in synaptic transmission and ranges in duration from tens to hundreds of milliseconds (short-term), to hours and days (long-term). Short-term plasticity plays crucial roles in synaptic computation, information processing, learning, working and …
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AMPA receptor diversity and dynamics during excitatory synaptic transmission
… and organisation of AMPARs therefore determines the fidelity of excitatory synaptic transmission and enables synaptic plasticity. Distinct functional properties are conferred on the AMPAR tetramer by the choice of core subunit (GluA1-4), as well as their association with various …
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Aberrant assembly and function of a hippocampal circuit in a genetic mouse model of schizophrenia
… in the dentate gyrus region find deficits in short term plasticity and decreases in the excitability of mature granule cells. Moreover, the dentate gyrus is one of two regions in the brain where adult neurogenesis occurs and this process is believed to be important for encoding new memories. …
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Potential for change: Characterizing synaptic plasticity following visual discrimination learning in adult rats.
Synaptic plasticity (long-term potentiation, LTP and long-term depression, LTD) plays an important role in processes of learning and memory formation. In order to provide a link between these neurophysiological and cognitive processes the following experiments were performed using behavioral, …
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Using feed-forward networks to infer the activity of feedback neuronal networks
… for some typical neuronal systems to determine the activity of the feedback neuronal network in the context of central pattern generating networks. In my study, I am interested in deriving reduced methods to understand the combined effect of short-term plasticity on the phase-locked …
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Characterisation of a novel Rab18 mouse model for Warburg Micro syndrome
… previously been generated and showed altered short term plasticity in the hippocampus and inhibition of Ca2+ mediated exocytosis of glutamate from cortical synaptosomes, but failed to recapitulate the characteristic ocular or neurological features of Warburg Micro syndrome. Mutations in …
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Neural Computation Through Synaptic Dynamics in Serotonergic Networks
… spiking neurons, synapses display striking short-term dynamics, undergo long-term changes in strength, and sculpt network-level processes in a complex manner. These synaptic dynamics, both in time and across space, may be a fundamental determinant of population-level computations and …
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Large-scale neuronal networks: from simulation technology to the study of plasticity-driven cognitive processes
… community that synaptic mechanisms, such as short-term synaptic plasticity and structural synaptic plasticity underlie cognitive processes like working memory and learning. Part III of this thesis is devoted to developing simulation and theoretical frameworks that shed light on the possible …
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Determining how stable network oscillations arise from neuronal and synaptic mechanisms
… neurons. The focus of this thesis was to determine the methods by which phase maintenance is achieved in an oscillatory network. This thesis examines the idea that phase maintenance occurs through the actions of intrinsic properties of isolated neurons or through the dynamics of their …
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The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)
… of ketamine on excitatory synaptic transmission, short term potentiation and synapse formation in the invertebrate animal model. Ketamine decreased synaptic transmission between VD4 and LPeD1 in a concentration dependent manner, but did not significantly affect short term synaptic plasticity …