Global ETD Search
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Showing 1 to 20 of 22 for “"short tandem repeats"”.
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Aspects of human relationship identification using short tandem repeats
Human short tandem repeat (STR) loci identification can be for linking material from a crime scene to an individual or linking two individuals. Paternity testing is one form of linkage where typically samples are tested between the mother, child and putative father (trio) and a probability (CPI) of …
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Uncovering the variability, regulatory roles and mutation rates of short tandem repeats
… Despite this rapid growth in understanding, short tandem repeats (STRs), genomic elements consisting of a repeating pattern of 2-6 bases, have remained poorly understood. Mutating orders of magnitude more rapidly than most of the human genome, STRs have been identified as the causal variants …
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Characterizing variation at short tandem repeats and their role in human genome regulation
… complex types of variation. Here we focus on Short Tandem Repeats (STRs) as a model for complex variation. STRs are comprised of repeating motifs of 1-6bp that span over 1% of the human genome. The level of STR variation and its effect on phenotypes remains mostly uncharted, mainly due to the …
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Algorithmic advances towards a fully automated DNA genotyping system
Short Tandem Repeats (STR) genotyping is a leading tool in forensic DNA analysis. In STR genotyping, alleles in a sample are identified by measuring their lengths to form a genetic profile. Forming a genetic profile is time-consuming and labor-intensive. As the technology matures, increasing demand …
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Using Matched Craniometric and Genetic Data to Assess the Population Structure of Texas-Mexico Border Migrants
… Using interlandmark distances (ILD) and short tandem repeats (STR) obtained from a sample of 32 Texas-Mexico migrants, this study investigates the within and between population variation of this unique data set. Genetic distances, Procrustes plots, and Mantel tests were conducted to …
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Chimerizmo analizė atskirose ląstelių populiacijose po alogeninės kraujodaros kamieninių ląstelių transplantacijos vaikams /
… immunomagnetic beads. Following polymorphisms of short tandem repeats between donor and recipient were compared. The analysis reveled that following myeloablative conditioning in patients with ALL and ALD analysis of ICP revealed persistent autologous hemopoiesis despite stable donor chimerism in …
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A mathematical model of polymerase chain reaction induced stutter
… loci. The alleles correspond to the number of repeats of microsatellites that are usually two to six base pairs in length called short tandem repeats (STRs); the number of repeats of various STRs defines a person's DNA fingerprint. This process introduces artifacts in measurement. Of particular …
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Investigation into X-STR haplotype frequencies for forensic human identification in South Africa
The utilisation of X-chromosome short tandem repeats (X-STRs) for DNA profiling has been demonstrated to be particularly useful in resolving distant familial relations and deficiency paternity testing. The implementation of X-STRs within a medico-legal context requires baseline frequency data for …
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Understanding and Improving Identification of Somatic Variants
… caller or using variants from only one platform. Short tandem repeats (STRs) are repetitive units of 2-6 nucleotides. STRs make up approximately 1% of the human genome and have been traditionally used as genetic markers in population studies. We conduct a series of in silico analyses using the …
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Development of Bioinformatic Methods for Data-Driven Forensic Short Tandem Repeat Analyses
Short tandem repeats (STRs) are a class of markers which currently play an important role in the forensic DNA typing. The arrival of massively parallel sequencing platforms (MPS) in forensic science reveals new information such as insights into the complexity and variability of the markers that …
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Analyse alter DNA zur Ermittlung von Heiratsmustern in einer frühmittelalterlichen Bevölkerung
… wurden sowohl autosomale und Y-chromosomale Short Tandem Repeats (STRs) als auch mitochondriale Sequenzabschnitte analysiert. Durch die Einbeziehung dieser polymorphen Marker lassen sich genetische Diversität sowie genetisch bedingte Substrukturierungen innerhalb einer Bevölkerung erfassen. …
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Structural determinants of mutability across cancer genomes
… these include Z-DNA, G-quadruplexes, inverted repeats that can fold in cruciforms and hairpins, direct and short tandem repeats that can mediate the formation of slipped structures and a subset of mirror repeats that fold in intramolecular triple stranded DNA also known as H-DNA. A systematic …
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The development of a new genetic test for grapevine cultivars using a computational genomics approach
… on the use of simple single repeat (SSR), or short tandem repeats (STR) markers have been developed to determine the genetic identity of different grapevine cultivars. However, the markers used in existing tests were identified more than 2 decades ago without optimization, and with the service …
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The 3d Genome As A New Dimension In Understanding Pathologic Short Tandem Repeat Instability
… expansion of repetitive DNA sequences termed short tandem repeats (STRs) serves as the mechanistic basis for more than 25 inherited human disorders. Patients with unstable repeat expansion diseases suffer from a complex array of symptoms, including: cardiac defects, cataracts, anxiety, …
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Application of single nucleotide polymorphisms (SNPs) to forensic casework in Malaysia
… demonstrated the advantage of these markers over short tandem repeats (STRs) in that they only require small amplicons. However, before applying to casework, it is important to develop allele frequency databases from relevant populations. The main aim of the study is to characterize three …
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Development, Validation and Applications of a Novel Multiplex Assay RM-Yplex Amplifying 13 Rapidly Mutating Y Chromosome Short Tandem Repeat Regions
… of amplifying 13 rapidly mutating Y chromosome short tandem repeats (RM Y-STRs) simultaneously was developed and optimised. This multiplex assay which was termed RM-Yplex is the first to include all 13 RM Y-STRs including DYF387S1, DYF399S1, DYF403S1a/b, DYF404S1, DYS449, DYS518, DYS526a/b …
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Molekulargenetische Untersuchungen an Überresten präkolumbischer Neuwelt-Camelidae aus dem Palpa-Tal (Peru)
… DNA (COI, Nd5 und Cytochrom b), chromosomale Short-Tandem-Repeats (STRs) und phänotypisch assoziierter Single-Nucleotide-Polymorphisms (SNPs) entwickelt und angewendet. Die Ergebnisse rezenter Populationen für Gene der mitochondrialen DNA sowie der erstellten Multiplex zur Analyse autosomaler …
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Application of autosomal INDELs as a forensic tool in Qatar
Short tandem Repeats (STRs) are the most commonly genetic markers used in forensic human identification. However, in some cases they are not able to yield complete profiles because of DNA degradation and/or inhibition. The STR profiling of the degraded/inhibited DNA samples can result in allelic …
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The Placenta Methylome: Novel Insights into DNA Modifications in the Human Placenta
… found to be enriched within intronic regions and short tandem repeats ((CA)n, (GT)n, (CACACA)n). This work is the first to characterise non-CpG methylation in placentas and highlight potential novel epigenetic regulatory mechanisms. The CpG methylation profile in the placenta also undergoes …
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Somatic microsatellite variability as a measure of DNA stability in cancer and DNA repair disorders
Microsatellites (MSTs) are short tandem repeats of motifs, 1 — 6 nucleotide in length, and are considered mutational 'hot-spots' and show a greater degree of somatic variability and population polymorphisms than surrounding DNA sequences. MSTs provide for a unique computational alignment problem …
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