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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"short peptides"”.
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Modelling short peptides in solution and at the interface
… andstructure. Using the example of catalytic peptides that are able to perform amide bond condensation, we examine the possibility of short peptide sequences adopting a conformation that supports an active site analogous to that found in protease enzymes such as subtilisin using molecular …
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A novel function for the eukaryotic translation elongation factor 1A
… factors, eEF1A also interacts with polypeptides after their release from the ribosome. It is further demonstrated that eEF1A does not bind to correctly folded full-length proteins, but interacts specifically with proteins that are unable to fold correctly in a cytosolic environment. This …
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A study of the C-terminus in prestin by designing cleavable constructs
… engineered prestin by inserting three types of short peptides, flexible, rigid and cleavable linkers, into different positions in the C- terminus and tested prestin’s funtionality, self-interactions, and lateral mobility in the membrane. First, we inserted short peptides between the last …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
… compounds, such as antimicrobial peptides (AMPs), anticancer peptides and trypsin inhibitors. Several kinds of AMPs, isolated and characterised from the skin of amphibians, have been studied by researchers to provide novel kinds of drugs and pharmacological agents for humans to …
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Lanthanide Binding Tag Peptides for Selective Separation of Rare Earth Elements
… strategies using lanthanide-binding tags (LBTs), short peptides that coordinate REEs with high affinity. Two approaches are investigated: (1) Foam-based separations, where LBT:REE complexes adsorb to the air-water interface and are collected in foam. Surface tension, x-ray reflectivity, and …
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Optimization of force fields for molecular dynamics
… that reproduces experimental melting curves of short peptides that are modeled with the usual functional form of a force field. We then apply the newly developed technology to study the liquid mixture of tert-butanol and water. We are able to obtain, after 4 iterations, the correct phase …
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Metallo-supramolecular cylinders and their peptide conjugates. Synthesis, dynamics and DNA recognition
… binding studies of the cylinders conjugated to short peptides and amino acids. In Chapter 1 an overview of the DNA molecular recognition by synthetic agents and biomolecules is presented, with a section dedicated to the selective recognition of DNA. In Chapter 2 the study of the dynamic …
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Advancements in polymer resins for solid-phase peptide synthesis
… has allowed for the facile, rapid synthesis of short peptides in a one bead/one sequence manner. This approach allows for screening peptide libraries for binding and catalytic activities. Once hits are found, the sequence of the active protein can be determined via mass spectrometry. However, …
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The design and structural characterization of oligomeric beta beta alpha mini-proteins
Oligomeric mini-proteins, short peptides with protein-like features, constitute valuable minimal models for the study of oligomeric proteins. Oligomerization is a common feature of cellular proteins that may confer structural and functional advantages. Oligomerization is proposed to have arisen by …
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The synthesis of bimane constrained peptides and their fluorescent and structural properties
… protein-protein interactions however constrained peptides, have shown to have great therapeutic potential. Short peptides display little secondary structure in aqueous solution and as such, peptide sequences derived from a protein-protein interaction interface for use as a protein-protein …
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Emergence, survival, and selection of metal-binding peptides in the prebiotic environment
… in the form of complex protein machinery, short metal binding peptides might have preceded modern metalloproteins. Such prebiotic, metal-binding motifs have been hypothesized to have existed through analyses of extant protein sequences. However, it is unclear how metal-binding motifs might …
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Structure studies of the human class II major histocompatibility complex protein HLA-DR1
… glycoproteins that bind antigens in the form of short peptides within the cell and present them to the T cell receptors on the surface T cells. In this thesis work, the structural aspects of the human class II MHC protein HLA-DR1 in complex with different peptides and also in the peptide-free …
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Structure, dynamics and applications of peptide-based nanomaterials
… in biomedicine, nanotechnology and catalysis. Short peptides can readily self-assemble into ordered structures on the nanometer length scale. The design rules for these constructs are not fully understood yet, which is a key issue in engineering new functional nanomaterials. This thesis …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… with host proteins, resulting in disease. Short peptides mimicking these regions were synthesised and the prevalence of anti-HERV antibodies was determined in RA patients and disease controls. Additionally, a novel real-time Polymerase Chain Reaction (PCR) assay was developed to accurately …
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Two Methodologies in Pursuit of the Elucidation of Copper (II)—Centered Bioinorganic Chemistry
… reduced. Furthermore, chemical synthesis of short peptides is easily performed and inexpensive in comparison to protein engineering, thus enabling further exploration, if deemed necessary, to be a feasible and economically viable possibility.
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Bioactive peptides from the skin secretion of Kassina senegalensis
Bioactive peptides in amphibian skin have been reported to have various pharmacological activities. The discoveries of these peptides have become hot spots in the development of new drugs.<br/><br/>In Chapter 3, peptides QUB-1641, QUB-1746, Kassinakinin S and Senegalin were isolated from Kassina …
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Self-Assembling Peptide Nanofibers RADA16 and IEIK13 for Rapid Hemostasis
… hemostat that meets all of these criteria. These short peptides self-assemble into nanofibers that entangle and gel in solution. Through the use of layer-by-layer (LbL) we can apply these hemostatic peptides to a bioabsorbable substrate in thin conformal layers to produce a bandage that is …
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Direct Quantitative Analysis of Multiple Micrornas
… the number of detectable miRNAs by conjugating short peptides of varying length to the DNA probes. These peptides acted as drag tags which allowed for the separation and detection of 5 miRNAs. To lower the limit of detection I combined DQAMmiR with isotachophoresis, an in-capillary …
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INVESTIGATION OF HETEROTRIMER-FORMING COLLAGEN-MIMETIC PEPTIDES THAT INCORPORATE AZA-GLYCINE RESIDUES
… have prompted the study of collagen-mimetic peptides (CMPs), short peptides used to simulate the structure and biology of collagen. The synthesis of heterotrimeric CMPs remains a significant challenge in the field, because a high level of control over trimer assembly is required to promote …
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Synthesis and biological evaluation of structurally diverse indole-based analogues as inhibitors of tubulin polymerization and synthesis of drug-linker constructs cleavable by enzymes present in the tumor microenvironment.
… constructs featuring protease-cleavable short peptides. The most promising drug-linker constructs will be conjugated to PS-targeting betabodies in future studies. The potent payloads, KGP18 and KGP156, are capable of inducing tumor damage through two complementary and distinct mechanisms: …
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