Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"shiny-app"”.
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Models and tools for multi-omics analysis of non communicable diseases [Modelli e strumenti per l'analisi multi-omica delle malattie non trasmissibili]
Questa tesi fornisce un'esplorazione approfondita dei dati molecolari relativi alle malattie non trasmissibili, con particolare attenzione al carcinoma mammario triplo negativo (TNBC) e alla sindrome di Sjögren. L'estrazione di informazioni da questo tipo di dati richiede competenze in …
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Using biological and chemical information to improve understanding of drug mechanism of action on the systems-level
… This presents an opportunity to investigate approaches for integrating information sources and computational methods for the elucidation of a systems-level view of compound MoA, which is the topic of this thesis. In the first chapter, causal reasoning algorithms were benchmarked for their …
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Using transcriptomic data to detect, understand, and treat injury in the context of drug toxicity and fibrotic disease
… to researchers in an interactive manner, the R/Shiny app “DILI Cascades” is presented in Chapter 4. Instead of drug toxicity, the last chapter then focusses on efficacy and aims to prioritise repurposing candidates, direct targets and downstream effectors which may promote alveolar regeneration …
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CANCERHUBS: A NETWORK-CENTRIC FRAMEWORK FOR CANCER GENE PRIORITISATION
… trae origine da mutazioni genetiche, le quali rappresentano il principale evento scatenante della trasformazione neoplastica. Tuttavia, tali lesioni non sono di per sé sufficienti a spiegare la complessità della malattia, che emerge dall'interazione con alterazioni epigenetiche e regolative …