Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"shh signaling"”.
-
Optogenetic regulation of protein activity in live cell
Signaling pathways extensively crosstalk among each other and result in different cellular phenotypes depending on the dynamic profile of protein activity. Conventional genetic and pharmacological approaches such as gene overexpression, use of growth factors or inhibitors have helped us delineate …
-
Role of retinal inputs and astrocytes for the development of visual thalamus
… I observed thalamus-projecting RGCs express SHH and astrocytes in visual thalamus express SHH signaling molecules. My results reveal that SHH signaling between RGC axons and astrocytes is critical for astrocytic fibroblast growth factor 15 (FGF15) expression in developing visual thalamus. …
-
Dynamic visualization and genetic determinants of Sonic hedgehog protein distribution during zebrafish embryonic development
… in part achieved by the proper distribution of signaling molecules, many of which exert their function by establishing gradients of concentration. Because of this property they were named "morphogens", or "form giving" substances. Among these, proteins belonging to the …
-
Guidance of Developing Motor Neurons into the Periphery
… of all MNs subtypes begins with Sonic Hedgehog (Shh) signaling in the spinal cord and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine axon trajectory. …
-
Specification of Stem Cells and Niche During Hair Follicle Morphogenesis
… divisions result in differential levels of WNT signaling in the daughter cells, with basal cells remaining WNT<sup>high</sup>, and suprabasal cells becoming WNT<sup>low</sup>. Using in utero lentiviral transduction and genetic mouse models, I created mosaic epidermis with gain- or …
-
Role of Sonic Hedgehog in Development of the Central Nervous System
Sonic hedgehog (Shh) functions as a morphogen to induce early dorso-ventral patterning of the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor …
-
The Generation of Alternative Transcripts as a Means of Regulating Phosphorylation in Sonic Hedgehog Medulloblastoma
… at the mRNA level. The sonic hedgehog (SHH) subtype of medulloblastoma (MB), the most common malignant pediatric cerebellar tumor, arises from granule neuron precursors (GNPs) through aberrant SHH signaling. Murine postnatal day 7 (P7) GNPs are highly proliferative and share strong …
-
Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
… retinal neurons. This work examines various the signaling pathways that trigger the Müller glia to re-enter the cell cycle and which molecules are required for retinal progenitors to differentiate into new neurons during adult zebrafish retinal regeneration. First, we show the Tg(nrd:egfp)/alb …
-
Vulnerability to G - Quadruplexes in BRCA2 - Null Medulloblastoma: A Protective Role for the PIF1 Helicase
… cerebellum, stimulated by Sonic hedgehog (Shh) signaling as well as other mitogens and can be isolated from the cerebella of mice during this developmental window that peaks at P7. After multiple symmetric divisions, GCPs exit the cell cycle, migrate into the inner granule layer of the …
-
The Apical Polarity Complex Protein, Pals1, Regulates Cell Fate In The Development of Cerebellum and Neocortex
… of well-established mitogenic/morphogenetic signaling through Shh and Notch in the Pals1 mutant. However, the localization of other apical complex proteins and tight junction proteins was severely affected by the absence of Pals1, which likely resulted in impaired cell adhesion and …
-
Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… progression and metastasis by alteration of signaling pathways. Recent observations suggest the role of MUC13 in drug resistance and apoptosis in several cancer types. Therefore, it is of great interest to explore the role of MUC13 in chemoresistance in PanCa. Unlike other cancer types, PanCa …