Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"sharp-wave ripple"”.
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Influence of perforant path synaptic excitation on the initiation of hippocampal sharp-wave ripple activity in vitro
Sharp-wave ripples (SWR) generated in the CA3 subregion of the hippocampus (HC) during rest and sleep appear to coordinate memory consolidation to the neocortex (NC) by (1) reactivating small subsets of neurons (i.e. cell-assemblies) that encode recent waking experience and (2) propagating this …
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Optogenetic investigation of normal and pathological rhythms in the hippocampal formation
… of two oscillatory patterns, the high frequency sharp-wave ripple oscillation thought to be involved in the long term storage of memories, and the high amplitude pathological oscillations associated with epileptic seizure. Hippocampal sharp-wave ripples are observed in CA1 during inactivity and …
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Neural correlates of locomotion, cues, and context in the interactions between hippocampus and lateral septum
… reward during conditioning. These cells display sharp wave ripple and theta modulation, spatial firing fields, and responses similar to the HPC during conditioning. These HPC-associated cells are not disproportionately speed or acceleration modulated, suggesting that these movement correlates are …
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Methods for Ripple Detection and Spike Sorting During Hippocampal Replay
In the rat hippocampus, fast oscillations termed sharp wave ripples and an associated sequential firing of neurons, termed replay, have been identified as playing a crucial role in memory formation and learning. The term 'replay' is used since the observed spiking encodes patterns of past …
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Replay of memories of extended behavior in the rat hippocampus
… spatial experience. Such 'replay' co-occurs with ripple events: short-lasting (~50-120 ms), high frequency (-200 Hz) oscillations that are associated with increased hippocampal-cortical communication. In previous studies, rats explored small environments, and replay was found to be anchored to the …
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Inhibition, Synapses, and Spike-Timing: Identification and disruption of pyramidal cell-interneuron interactions in SPW-Rs
… to circuit activity, such as theta and sharp wave-ripple oscillations. The precise roles of each interneuron group is not well understood, though characterization of their activity reveals mechanisms underlying hippocampal circuit computation. In this dissertation, I aim to identify and …
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Latent variable models for hippocampal sequence analysis
… making. Replay is observed during hippocampal sharp-wave-ripple-associated population burst events (PBEs) and is critical for consolidation and recall-guided behaviors. Notably, these PBEs occur during times of inactivity, so that their representations cannot easily be matched with observable …
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Multifunctional Polymer Fiber Probes for Biomedical Application
… infusion of CB1R agonist downregulated theta and sharp wave-ripple oscillations (SPW-Rs). Furthermore, we found that CB1R activation reduces sharp wave-ripples by impairing the innate SPW-R-generating ability of the CA1 circuit. Microscale electroporation devices are mostly restricted to in vitro …