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Showing 1 to 20 of 35 for “"sgc"”.
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Sistema de Gestión del Conocimiento (SGC) para Gobernanza en Implantaciones SaaS
El presente trabajo final pretende confirmar, mediante el análisis, diseño y desarrollo de un prototipo de producto, que el uso de un middleware semántico basado en ontologías y bases de datos triplestore para la gestión de grafos de conocimiento, permite gobernar de forma controlada las …
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No-Independent Modulation of Soluble Guanylyl Cyclase (Sgc) Activity and Function
<p>Soluble guanylyl cyclase (sGC) plays a key role in the nitric oxide (NO) signaling pathway, where it functions as an NO receptor and generator of a secondary intracellular messenger, cGMP. In addition to NO, investigators have identified a number of proteins that interact with sGC and modulate …
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Regulation of the nitric oxide receptor, soluble guanylyl cyclase
Soluble guanylyl cyclase (sGC) is the best established receptor for nitric oxide (NO) and regulates a great number of important physiological functions. Surprisingly, despite the wellappreciated roles of this enzyme in regulation of vascular tone, smooth muscle cell proliferation, platelet …
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Transgenerational Effects of Synthetic Glucocorticoids on Offspring Behaviour and HPA Development in Guinea Pigs
… or synthetic glucocorticoid treatment [sGC]) alters the trajectory of development and increases the risk for chronic diseases later in life. Approximately 10% of pregnant women are at risk for delivering prematurely and receive treatment with sGC to reduce neonatal morbidity and …
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The role of potassium buffering and apoptosis of trigeminal satellite glial cells in the induction and maintenance of orofacial neuropathic pain in rats
Satellite glial cells (SGC) are laminar cells that wrap completely around the sensory neuron and are responsible for buffering extracellular K+ after neuronal excitation. A decrease in the potassium buffering capacity of SGC has been associated with neuropathic pain (NP) behavior and apoptosis. …
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Structure and dynamics of soluble guanylyl cyclase
Soluble guanylyl cyclase (sGC) is one of the key enzymes involved in many fundamental biological processes including vasodilatation. It can be allosterically activated by synthetic compound such as YC-l. Recently, the 3D structure of adenylyl cyclase (AC), which is a homologue of sGC, was …
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Comparison of Marshall Compactor and Superpave Gyratory Compactor for Mix Design and Control of Airport Asphalt Mixtures
… Marshall hammer or Superpave Gyratory Compactor (SGC). The specifications require a compaction level of 50 blows or gyrations for asphalt mixtures for airfield pavements serving aircraft of 60,000 pounds or less, and 75 blows or gyrations for mixtures to support aircraft weighing more than 60,000 …
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Guía para la implementación del SGC basado en la norma ISO 9001:2015 en microempresas del sector construcción colombiano, como HM arquitectura e ingeniería SAS
… de un Sistema de Gestión de Calidad (SGC) basado en la norma ISO 9001:2015, para microempresas del sector constructor, tomando como caso de estudio a HM Arquitectura e Ingeniería SAS. Su propósito es ofrecer un modelo práctico que facilite la adopción del SGC en microempresas del …
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Investigation of compaction characteristics of subbase material using the superpave gyratory compactor
… Gyratory Compactor testing to determine if the SGC is a valuable tool for the prediction of airport pavement performance and design. The practicality of the SGC was based on extensive laboratory and field testing of three unbound materials including P-154, P-209, and DGA, which are the subbase …
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Σύνθεση, αποτίμηση και μελέτη της σχέσης χημικής δομής βιολογικής δραστικότητας στο καρδιαγγειακό σύστημα, νέων τετραϋδροϊνδολικών παραγώγων
… στόχο αποτελεί η διαλυτή γουανυλική κυκλάση (sGC), η οποία βρίσκεται στο επίκεντρο του ερευνητικού ενδιαφέροντος την τελευταία δεκαετία. Παρόλο που ανακαλύφθηκε περίπου πριν από τέσσερις δεκαετίες ως μέλος της οικογένειας των κυκλασών, η έρευνα που ακολούθησε την ανακάλυψή της δεν …
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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION
… as an inhibitor of soluble guanylyl cyclase (sGC). A significant induction of oxo8GTP in cell-free preparations as well as in PC12 and HEK 293T cells exposed to physiologically relevant oxidative conditions generated with 10 ?M copper sulphate and 1mM L-Ascorbic Acid (Cu/Asc) is also reported. …
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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION
… as an inhibitor of soluble guanylyl cyclase (sGC). A significant induction of oxo8GTP in cell-free preparations as well as in PC12 and HEK 293T cells exposed to physiologically relevant oxidative conditions generated with 10 ?M copper sulphate and 1mM L-Ascorbic Acid (Cu/Asc) is also reported. …
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The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia
… sensory neurons and their satellite glial cells (SGCs). To examine the impact of suppressing neuronal p75NTR expression on known molecular modulators/regulators of the nociceptive state namely, the sodium channels NaV1.8 and NaV1.9, the nerve growth factor receptor TrkA, the potassium channel …
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The development of S-glycosylcysteine derivatives for use in glycan-binding assays
… the synthesis of a S-glucosylcysteine derivative SGC, or methyl N-(6-aminohexanoyl)-S-(β-D-glucopyranosyl)-L-cysteinate trifluoroacetate 67, as well as its 2-acetamido analogue SAGC, or methyl N-(6-aminohexanoyl)-S-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-L-cysteinate trifluoroacetate 74. The …
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The Sandwich Synapse: Trans-glial Signaling Between Neuronal Somata in the Dorsal Root Ganglion
… enveloped by individual satellite glial cell (SGC) sheaths. However, a subset of NS are closely-apposed and separated solely by a thin SGC membrane septum, forming a structural cell trimer. Using patch clamp electrophysiological recording, we reported that repetitive stimulation of one NS …
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Diseño de un sistema de gestión de calidad bajo la norma ISO 9001/2000 para los procesos estratégicos de la Alcaldía de San Vicente.
… y por lo tanto en la propuesta se elabora el SGC para la Alcaldía Municipal de San Vicente y para el cual se tomaron como guía los requisitos establecidos en la Norma ISO 9001/2000 se da a conocer el presupuesto estimado para la implementación del SGC así como también el presupuesto para la …
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Spring Forward or Fall Back? Redox State as a Determinant in Glutamate Signaling Pathways Adjusting Our Brain Clock
… receptor (RyR) and soluble guanylate cyclase (sGC), in the early night and late night, respectively. However, the determinant of this signaling-pathway bifurcation remains unknown. I tested the hypothesis that cellular redox state functions as this determinant. I found that general redox state …
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Evaluation of the IDEAL-CT for Hveem-Designed Asphalt Mixtures in Nevada
… been applied to Superpave Gyratory Compacted (SGC) specimens; this study investigates its use with Hveem-compacted specimens, highlighting adaptations for smaller diameters. The sensitivity of the CT Index to changes in mix design parameters, such as aggregate gradation and asphalt binder …
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Modelo para la gestión de la calidad según ISO 9001 aplicable al desarrollo profesional de la Ingeniería de Edificación
… de Sistemas de Gestión de la Calidad (SGC) por sociedades profesionales y/o profesionales libres dedicados al ejercicio profesional de la Ingeniería de Edificación. Se realiza con el convencimiento de que la implantación de un SGC en la actividad diaria de estos técnicos favorece la …
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Quantifying Workability, Compactability, and Cohesion Gain of Asphalt Emulsion Cold In-Place Recycling
… for UGM, and the Superpave Gyratory Compactor (SGC), typically used for HMA, were compared by evaluating densities, tensile strengths, and compaction metrics of FDR samples produced using each method. The modified Proctor hammer produced samples with the highest dry unit weights; however, …
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