Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"sexual differentiation"”.
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Models for Investigating the Biology of Sexual Differentiation
… differences exist within the sexes as well. Sexual differentiation is the process of development of these differences. The study of sexual differentiation is itself a discipline, with different concepts and methods applied across structures and species. Explanations for the biology of the …
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BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
… potential links between germ cell pluripotency, sexual differentiation and cancer susceptibility. A recent GWAS study [3] identified association of BMP7 with testicular dysgenesis syndrome; however the molecular mechanisms behind this association remain unknown. Previously, we described the …
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Sexual differentiation of somatic and germ cell lineages of the mouse gonad
The process of gonadal sex differentiation in mammals remains poorly understood despite the identification of a few key genes such as Sry and Sox9. To further our understanding of gonad organogenesis, a PCR based subtractive hybridization was performed to identify mouse genes that demonstrate …
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The effect of prenatal androgen exposure on sexual differentiation and postnatal growth in beef cattle
Masculinization of the female fetus by administration of androgens has been studied in domestic and many laboratory species. Research concerned with cattle has been based solely on neonatal examination of the genital structures; no studies have reported on postnatal growth and development of …
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Molecular mechanisms governing germ line development in zebrafish and the role of this lineage in sexual differentiation
Während der Embryonalentwicklung des Zebrafisch (Danio rerio) werden die Urkeimzellen sehr früh von den anderen Zelllinien durch eine maternale, spezifische Form des Cytoplasmas, dem so genannten Keimplasma, unterschieden. Bei den nachfolgenden Zellteilungen verteilt sich dieses Keimplasma …
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Genetic Analysis of The Function of The Drosophila Doublesex-Related Factor Dmrt93B
… factor) proteins generally associated with sexual differentiation in many organisms share a common DNA binding domain and are often expressed in reproductive tissues. Aside from doublesex, which is a central factor in the regulation of sex determination, Drosophila possesses three different …
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Sex difference in the endocrine response of adult domestic chickens to gonadotrophin-releasing hormone-I
… and in vitro, and to determine the mechanism for sexual differentiation of GnRH-I-induced LH secretion. The magnitude and profile of the GnRH-I-stimulated LH response, and the sensitivity to GnRH-I were shown to be functions of the anterior pituitary gland. There was less LH in gonadotroph cells …
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Evaluation of the relationships between watershed-scale land use and contaminants in aquatic environments and the use of freshwater snails as indicators of impairment
… gametogenesis which could allow disruption of sexual differentiation by environmental contaminants, but further study of the effects of specific contaminants on sexual differentiation in this species is needed. Population densities of L. carinata were related to in-stream nutrient …
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Lifecycle Progression And The Sexual Development Of The Apicomplexan Parasite Cryptosporidium Parvum
… intestinal enterocytes where parasites multiply asexually followed by sexual differentiation. Parasites have sex and then undergo sporulation in the host to produce mature oocysts. Oocysts re-infect the host or are transmitted via feces. Cryptosporidium infection in cancerous cell lines (HCT-8 and …
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Sex And Heterochromatin: An Investigation Of Sexual Dimorphism In Drosophila Melanogaster
… heterochromatin is generally not thought to be sexually dimorphic. The genetic basis for the regulation of sex-specific heterochromatin was completely unknown. </p> <p>To determine if roX RNAs localize directly at the heterochromatic regions that they regulate, I generated an MS2-tagged roX1 …
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Develoment and Application of Chemical Strategies to Study Protein Fatty-Acylation in Eukaryotes
… I showed that the Erf2-Erf4 PAT modulates sexual differentiation, and that upregulation of its expression is required to establish the meiotic palmitoylome. Importantly, I demonstrated that changes in Erf2- Erf4 levels within the physiological range control PAT specificity and result in the …
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Effects of endocrine disruptors in zebrafish (Danio rerio) as revealed with the fish sexual development test
… one central target of EDCs. Especially during sexual differentiation of organisms, the consequences of such a misbalance may easily lead to population-relevant effects. Thus research into EDCs has been massively intensified over the last decades. Since, at international levels, there is high …
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Influences of atrazine on gonadal differentiation in Xenopus laevis tadpoles during metamorphosis
… were exposed for 48, 96 and 144 h during sexual differentiation to 1.8, 19 and 48 og/L atrazine. Following the exposure, tadpoles were microdissected for histological examination of the gonadal-kidney complex. The experimental tadpoles showed no significant difference in body weight, body …
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Effects of bisphenol A exposure during early development on behavior and anatomy of the prefrontal cortex in adult male and female rats
… during early development can affect behavior and sexual differentiation of the brain in rodents, although few studies have examined effects on cognitive behavior and associated areas of the brain. The current study examined if exposure to BPA during early development alters general measures of …
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Understanding the effects of sex chromosomes and sex hormones on sex differences
Biological factors that determine sex and drive sexual differentiation have long been established in humans and other mammalian species. Yet there is a limited understanding of the mechanisms by which these factors give rise to sex-biased outcomes in health and disease. Growing evidence for sex …
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The genomic and genetic basis of mammalian sexual reproduction : sequence of the mouse Y chromosome, and a gene regulatory program for meiotic prophase
Mammalian sexual reproduction requires sexual determination, sexual differentiation, and the production of haploid gametes. In this thesis, I examined the genomic evolution of the mouse Y chromosome, which instructs sexual determination, and genetic regulation of a program of gene expression for …
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Transcript Diversity In The Protozoan Parasite Toxoplasma Gondii
… in regulating stage-specific expression during sexual differentiation and sporogony. These results provide the basis for revising the reference T. gondii genome annotation available at ToxoDB.org and GenBank. Strategies developed in this dissertation also provide the basis for defining …
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Investigating the role of neuroendocrine signaling in the regulation of sexually dimorphic behavior of C. elegans
Sexual dimorphisms are a fundamental feature of the nervous systems of diverse animal species and the identification and functional characterization of such features is critical to our understanding of differences in behavior between the sexes. While sexual dimorphisms in nervous system …
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Identification and Characterization of Y Chromosome and M Locus Genes in Anopheles and Aedes Mosquitoes Using the Chromosome Quotient Method
… and fruitless, two key regulators of downstream sexual differentiation. Ectopic expression of Nix resulted in masculinization of genetic females. Based on these results, we concluded that Nix is a male-determining factor in Aedes aegypti. We also characterized large portions of the Anopheles …
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