Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"severe obesity"”.
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Treatment of severe obesity in adolescents; a mixed method approach
Adolescent obesity is a public health problem associated with significant immediate and long-term health complications (Kelly et al. 2013). Amongst obese adolescents, a third are severely obese (BMI >99.6th centile UK90 reference charts) (Ogden et al. 2012) with severe obesity the fastest growing …
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Low-Protein Meal Challenge as a Predictor for Weight Loss Success in Severe Obesity
… to the prospective implementation in routine obesity care. To establish a clinically applicable method for specific metabolic phenotyping, the conducted study evaluated resting metabolic rate (RMR) measurement before and after 24-hour fasting and a low-protein meal test (LPMT) overfeeding …
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CHANGES IN SERUM HOMOCYSTEINE LEVELS AFTER ROUX-EN-Y GASTRIC BYPASS SURGERY IN SEVERE OBESITY
… cardiovascular disease. It is well known that obesity is also a modifiable and independent risk factor for cardiovascular disease. Extensive research has shown that weight loss produced by both traditional methods (dietary restriction/exercise) and gastric bypass surgery can improve several …
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Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
… as those with inborn errors of immunity, cancer, obesity, and on immunomodulatory drugs, make up a large proportion of the UK population. These individuals are at increased risk from COVID-19 disease but also are more likely to respond poorly to vaccination. Vaccine efficacy in these groups is …
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Weight Loss Surgery Decision Process: A Grounded Theory Study
… the decision making process of morbidly or severely obese individuals who engage in weight loss surgery and the role of nurses in this process using a grounded theory research design. Morbid or severe obesity is a chronic illness that is increasing in prevalence throughout the United States. …
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MODULATION OF TASTE PERCEPTION AS A POSSIBLE STRATEGY IN OBESITY TREATMENT: NEW PERSPECTIVES FOR PRECISION NUTRITION
… genetic aspects, environment and pathologies. Obesity is a constantly growing multifactorial disease, due to a positive balance between caloric intake and total energy expenditure. Often, also related to metabolic disorders, obesity is also linked to behavioural dysfunctions such as binge …
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Body Temperature and Diet As Drivers of Obesity Development
<p>Metabolic disease and obesity affect millions of individuals worldwide and the prevalence of obesity is expected to continue to rise. Mechanisms underlying diet-induced metabolic disease and obesity are complex and are largely unknown. In this dissertation research, we aimed to make advances …
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The attitudes and beliefs of medical residents and fellows toward obesity
… medical residents’ and fellows' attitudes toward obesity. To our knowledge, no study has investigated the attitudes of medical fellows or examined the attitudes and beliefs of the various specialties of medical residents specializing in various toward obesity. Moreover, no study has researched the …
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The characterization of obesity and noninsulin dependent diabetes mellitus in Swiss Webster mice associated with late-onset hepatocellular carcinoma
Despite increased awareness of the obesity epidemic and a higher incidence of the metabolic syndrome in humans, the incidence of obesity and its comorbidities-most notably, type II diabetes (T2D) and cardiovascular disease (CVD)-continues to increase. Although numerous animal models are available …
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Maintained weight loss: facilitators and barriers
… healthcare systems and the individuals. Obesity can threaten the individual’s mental and physical health and quality of life. For the person living with the classification of severe obesity the frequency and severity of comorbidities make weight loss increasingly difficult. Whilst …
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EXAMINATION OF PSYCHOSOCIAL FACTORS ASSOCIATED WITH DEPRESSION AND ANXIETY WITHIN A YEAR OF BARIATRIC SURGERY
… surgery is an established intervention for severe obesity, its impact on mental health outcomes remains unclear, with mixed findings across existing literature. This study examined the extent to which psychosocial and demographic factors, specifically type of bariatric surgery, history of …
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An exploration into the decision-making process of female patients going abroad for bariatric surgery: an interpretative phenomenological analysis
… many a life-saving intervention for people with severe obesity and serious health complications such as type 2 diabetes (Courcoulas et al., 2024; Ebadinejad et al., 2022). Decision making forms an important part of the pre-surgery process to have bariatric surgery, including deciding whether to …
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A pilot study on the effects of bariatric surgery on flavor perception and eating bevahior 2-5 years post-surgery
The prevalence of obesity, a disease that poses several health and metabolic concerns, continues to grow worldwide. As of today, bariatric surgery is the only long-term successful treatment for weight loss for those with severe obesity. After receiving bariatric surgery, individuals self-report …
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Molecular characterization in human neurons of genes associated with the control of bodyweight and feeding behaviour
Obesity is a major risk factor for many common diseases and has a significant heritable component. It is well documented that a powerful genetic component underlies the large variation in human body size in response to the modern day ‘obesogenic’ environment. Therefore, genetic approaches can be …
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Socioeconomic inequalities in non-communicable diseases in South Africa
… NCDs and some causes of NCDs including smoking, obesity, high blood pressure; use of screening services and effective coverage for hypertension management. The prevalence of smokers is 18.7%, the population average BMI is 26.38 kg/m2, and the prevalence of hypertension is 29.7%. The distribution …
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Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
The prevalence of obesity is exponentially increasing worldwide. Although strategies such as exercise, nutritional intervention, and pharmaceutical therapies including resveratrol have been extensively studied in lean or obese individuals, the effects of those interventions in severe obesity …
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Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice
… including decreased energy expenditure, severe insulin resistance, diabetes, dyslipidaemia and increased body weight. Leptin also has several extra-hypothalamic effects, and its neurogenic actions regulate anxiety and depression-like behaviours. Moreover, leptin deficiency leads to the …
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Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice
… including decreased energy expenditure, severe insulin resistance, diabetes, dyslipidaemia and increased body weight. Leptin also has several extra-hypothalamic effects, and its neurogenic actions regulate anxiety and depression-like behaviours. Moreover, leptin deficiency leads to the …
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THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
The skeletal muscle of severely obese individuals (BMI > 40 kg/m²) is characterized by a depressed ability to oxidize fatty acids and a failure to upregulate fatty acid oxidation (FAO) in response to increased lipid availability, both of which may contribute to a positive lipid balance and weight …
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Mapping the Feeding Circuitry in the Mouse and Human Brain
The prevalence of obesity and its associated comorbidities has significantly grown over the last 50 years, imposing a great burden on people’s health. Consequently, understanding the mechanisms by which energy intake and bodyweight are controlled is extremely important to help us to further improve …
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