Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"severe infection"”.
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Identification of Bacteroides genes involved in Metronidazole resistance
… can become opportunistic pathogens and cause severe infection. The antibiotic of choice for treating such infections is metronidazole, a DNA damaging agent. Metronidazole enters the bacterial cell as an inert prodrug, and is activated by cellular reduction into a cytotoxic compound which is …
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Epidemiology of Soybean Pod and Stem Blight
… were used. Only in 1978, Phomopsis sp. infection on stems and pods was significantly greater in the inoculated plots when compared with the check plots. Both stem and pod infection in plots protected with benomyl were significantly lower than those in check and inoculated plots. Plant …
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Der prognostische Wert von S-100-Protein und Procalcitonin nach präklinischer Reanimation
… outcome after cardiac arrest, without signs of severe infection or concomitant sepsis. Based on this observation, studies on larger numbers of patients should prove the predictive value of PCT in those patients.
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Mathematical Modeling of Dengue Viral Infection
In recent years, dengue viral infection has become one of the most widely-spread mosquito-borne diseases in the world, with an estimated 50-100 million cases annually, resulting in 500,000 hospitalizations. Due to the nature of the immune response to each of the four serotypes of dengue virus, …
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Improving Early Sepsis Identification on Inpatient Units
… condition that arises from a complication of severe infection characterized by a systemic inflammatory response (SIRS). As a time critical illness requiring early identification and treatment, delayed recognition of sepsis can lead to organ failure and death. Effective sepsis protocols need to …
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Modeling HIV-1 Infection and Immune Responses Under Drugs of Abuse
… can make it harder to effectively manage HIV infections. It is thus important to gain insights into the effects of drugs of abuse on HIV dynamics. This dissertation presents mathematical models that help inves tigate the effects of morphine-altered antibody responses on SIV dynamics, effects of …
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Comparative efficacy of azole compounds targeting sterol 14-demethylase against multiple isolates of Acanthamoeba castellanii and polyphaga
… diseases depending upon the anatomical site of infection and the immune status of the host. The most common infection caused by Acanthamoeba spp. in immunocompetent humans is Acanthamoeba keratitis a severe infection of the eye that has increased in prevalence mainly due to the increase in the …
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Role of msaA Gene in Regulation of the msaABCR Operon and Biofilm Development in <i>Staphylococcus aureus</i>
… diseases ranging from chronic biofilm associated infection to acute life threatening infection such as bacteremia, pneumonia, osteomyelitis, or endocarditis, despite the progress with antibiotics used in the treatment of bacterial infections. Furthermore, increased use of prosthetic and indwelling …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… burdens, has led to the hypothesis that severe disease is immune-mediated. Our previous studies showed that intraperitoneal infection of wild-type mice with virulent Ehrlichia (IOE) results in CD8+ T cell-mediated fatal toxic shock-like syndrome marked by apoptosis of CD4+ T cells, a weak …
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Preliminary Analysis of Vital Proteins of the Human Respiratory Syncytial Virus
… in adulthood. It is a serious global problem as severe infection and death can result in the very young or very old and in immunocompromised people. The related bovine Respiratory Syncytial Virus is a serious problem for the farming community. To date, there is no effective treatment for …
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The phenotypic and molecular responses of Listeria monocytogenes to stressors
… and the causative agent of listeriosis, a severe infection resulting in septicaemia, meningitis and still birth. Infection typically arises through the consumption of contaminated foodstuffs. L. monocytogenes is a hardy organism which can survive several food control measures. Psychotrophic …
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A retrospective study of patients with biologics treatment at Groote Schuur and Red Cross Children's War Memorial Hospitals
… cost and concern of adverse events, particularly infections, limit the use of biologic disease-modifying anti-rheumatic (bDMARD) therapies. We undertook this retrospective study to document their use for immune-mediated diseases (IMDs) and explore the efficacy, safety, adherence and screening …
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Modeling of NK Cells in Pediatric Patients With Unusually Severe or Recurrent HSV Using High-Dimensional Flow Cytometry
<p>HSV infection is broadly spread all over the world with some patients having severe and/or recurrent HSV infections. Our lab studies human Natural Killer (NK) cells, which are important in innate immune responses to viral infections and tumors. A publication in 2013 by Ornstein et al from our …
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Escherichia Coli ST131 Collected From Companion Animals Can Cause Cystitis and Pyelonephritis in a Murine Model of Urinary Tract Infection
… (UPEC) cause 80% of uncomplicated urinary tract infections (UTI) globally. Since the mid- 2000s, a subset of UPEC called ST131 have undergone rapid pandemic spread. ST131 are a major cause of UTIs that lead to serious complications in humans like pyelonephritis and sepsis. In companion animals, …
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SARS-CoV-2 Variants and Vaccines
… It presented with pneumonia-like symptoms and infections ranged from mild to severe, requiring hospitalisation and medical intervention to prevent death. Due to a lack of previous immunity, SARS-CoV-2 spread around the globe at a rapid rate requiring the declaration of a pandemic and for …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… immune mediators and cell populations in adult severe influenza infection. Single-cell RNA sequencing of tracheal aspirate cells from pediatric subjects experiencing acute respiratory failure (ARF) showed that distinct T cell subsets within the lower respiratory tract exhibited transcriptional …
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Die Pharmakokinetic von Meropenem bei Patienten mit schweren Infektionen
Meropenem ist ein Carbapenem-Antibiotikum mit breitem Wirkspektrum, guter Verträglichkeit und hoher Gewebepenetration, auch in infiziertes Gewebe. Obwohl Meropenem aufgrund seiner guten pharmakokinetischen und pharmakodynamischen Eigenschaften häufig zur empirischen Therapie kritisch kranker …
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From Acute to Chronic: Outcomes and Diagnostics in Traumatic Brain Injury
… in the acute care setting. To explore this, severe infection/sepsis was used as an exemplar condition, with the acute profile of brain injury biomarkers examined in patients presenting to the ED with suspected sepsis. Elevated biomarker levels were observed in patients with suspected sepsis, …
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Cortisol perturbation in the pathophysiology of septicaemia, complicated pregnancy and weight loss/obesity.
… is a life threatening condition that complicates severe infection and is characterized by systemic inflammation and refractory hypotension. High plasma total cortisol levels and attenuated responses to synthetic ACTH stimulation are associated with increased mortality. The use of corticosteroids …