Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"severe acute respiratory syndrome coronavirus 2"”.
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Severe Acute Respiratory Syndrome Coronavirus-2 Vaccine Development: A Virus-Like Particle Vaccine Approach
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 as a highly infectious virus that spread rapidly and was declared a pandemic by the World Health Organization (WHO) in March of 2020.1 SARS-CoV-2 infection causes respiratory disease (Coronavirus Disease; COVID-19), …
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The Interaction Between Host G3BP and Viral Nucleocapsid Protein Regulates SARS-CoV-2 Replication
… interactors of the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the functional consequences of the G3BP-N interaction in the context of viral infection have remained unclear. Here we used structural and biochemical analyses to define the …
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SARS-COV-2 DISSEMINATION USING UNITED STATES COUNTY ADJACENCIES
Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is increasing amongst the world’s population at an alarming rate. Reducing the spread of SARS-CoV-2 is paramount for public health officials as they seek to effectively manage resources and potential population …
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AN IMPROVED GENOMIC SURVEILLANCE APPROACH TO DISSECT THE SARS-COV-2 PANDEMIC
Genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only approach to rapidly monitor and tackle emerging variants of concern (VOC) of the COVID-19 pandemic. Such scrutiny is crucial to limit the spread of VOC that might escape the immune protection conferred …
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Insights in Response to Statewide COVID-19 Sampling in Indiana
… Health conducted a longitudinal study of novel severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus, the cause of COVID-19 disease, to understand the number of past and current infections as well as the prevalence of disease in the State of Indiana by conducting a survey to …
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Computational Molecular Docking Studies of Small Molecule Inhibitors With the SARS-CoV-2 Spike Protein Variants: In-Silico Drug Discovery Using Virtual Screening and Drug Repurposing Approaches
<p>The pandemic caused by the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has caused a global public health crisis of nearly unprecedented scale. In the years following the outbreak, the scientific community has mobilized to develop several vaccines and …
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
Human coronaviruses (HCoVs) have garnered intense interest due to the large outbreaks caused by severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which have …
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Drug Repurposing for COVID-19 Using Molecular Docking Tools
<p>Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious and mortal, finding a treatment is time critical. Drug repurposing is probably the quickest and safest approach in our arsenal. However, testing every drug in a brute force manner would require a lot of …
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Subversion of innate antiviral immunity by SARS-CoV-2: An example from the study of nonstructural protein 16.
… the molecular basis of innate immune evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important consideration for designing the next wave of therapeutics. Here, we investigate the role of the nonstructural protein (NSP) 16 of SARS-CoV-2 in infection and pathogenesis. …
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SARS-COV-2 EVOLUTION AND TRANSMISSION: WITHIN-HOST, BETWEEN-HOST, AND BETWEEN-SPECIES
The evolution and adaptation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, remain incompletely understood. This thesis aims to elucidate the temporal and mechanistic aspects of these viral changes through comprehensive genomic analyses. …
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Characterization of a novel mouse model and vaccines for pulmonary pathogens
Lower respiratory tract (LRT) infections are an important cause of morbidity and mortality worldwide, especially in developing countries. There are many causes of LRT infections, including numerous viral and bacterial etiologies. The research presented in this thesis focuses on two important …
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The Effect of the Incorporation of Heavy Metal Zeolites into 3-D Printed Surgical Guide Resin on the Surface Stability of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the virus responsible for the COVID-19 global pandemic, spread around the world at an alarming rate. The transmission was of great concern, as was the ability of the virus to survive in the environment for extended periods of time. …
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Immune Transcriptome and B cell receptor repertoire in COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulting in Coronavirus disease 2019 (COVID-19) was declared by the World Health Organization a global pandemic on March 11, 2020. SARS-CoV-2 primarily infects respiratory epithelial cells, and results in a range of clinical …
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Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa
Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality …
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Knowledge, attitudes and practices towards COVID-19 disease among community members of Collins Chabane Municipality in Limpopo Province
A novel coronavirus known as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also known as coronavirus disease of 2019 (COVID-19) is an acute respiratory disease that has received attention in the whole world and has spread throughout. The current study investigated the knowledge, …
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Development of monoclonal antibodies targeting T cell coinhibitory proteins TIM-3 and TIM-4
… TIM-4 respectively versus non-target proteins severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike S1 and SARS-CoV-2 receptor-binding domain proteins respectively. This revealed 21 anti-TIM-3-Fc scFv antibody phage monoclones with affinity and specificity to TIM-3-Fc and 8 …
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Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and adapt long after it first emerged in 2019. As the causative agent of the coronavirus disease 2019 (COVID-19), a tremendous effort has been made to understand the molecular pathogenesis of SARS-CoV-2. Recent …
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Molecular Mechanisms Behind Sars-Cov-2 Induced Host Genome Restructuring
<p>Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has caused unprecedented morbidity and mortality worldwide.<strong> </strong>There are two pathophysiological hallmarks associated with severe patient outcomes after SARS-CoV-2 acute infection, namely delayed/weakened interferon …
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Genetic diversity of sars-cov-2 in southern province of Zambia.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has spread globally with catastrophic effects on the public health system. Four main Variants of Concern (VOCs), namely Alpha, Beta, Delta and Omicron, have been associated …
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