Global ETD Search
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Showing 1 to 9 of 9 for “"sesquiterpene lactones"”.
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Contribution to the elucidation of the anti-inflammatory activity of Sesquiterpene Lactones
To analyze the mechanism by which sesquiterpene lactones (SLs) inhibit DNA binding of the transcription factor NF-kB, the role of cysteine residues in its DNA binding domain was tested using single amino acid mutants of the p65 subunit. The results confirm that p65 is alkylated by SLs, and that the …
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Characterization of Molecular Content, Cytotoxicity, and Anti-Inflammatory Activity of Extractions from Eupatorium serotinum
… difficulty of motion. Recently, the effect of sesquiterpene lactones such as Helenalin from <em>Arnica montana</em> have been studied for their anti-inflammatory properties. In this study, we identified and harvested samples of <em>Eupatorium serotinum</em>, a plant historically used by Native …
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Action of Allelochemicals on Algal Growth and Photosystem Ii Efficiency
… 1 μM. The growth-inhibition threshold for other sesquiterpene lactones, alkaloids, coumarins, flavonoids, and quinones ranged between 10 and 100 μM. The inhibition threshold was 100 μM or higher for benzoic and cinnamic acids. Sesquiterpene lactones were PSII inhibitors that had a positive …
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Studies towards the synthesis of the guaianolide and pseudoguaianolide skeleton
… thesis. Guaianolides and pseudoguaianolides are sesquiterpene lactones and share a sommon backbone: the guaiane skeleton. Hundreds of natural products belong to these families of compounds. The guaiane skeleton is characterised by a bicyclo[5.3.0]decane ring system (perhydroazulene). Among the …
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Searching for Anticancer Agents and Antimalarial Agents from Madagascar
… (Baill.) Le Thomas (Annonaceae); five new sesquiterpene lactones from Polycline proteiformis Humbert (Asteraceae). The structures of all compounds were determined by analysis of their mass spectrometric, 1D and 2D NMR, UV and IR spectroscopic and optical rotation data. Other than structure …
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Natural product chemistry in drug discovery
… second reports the isolation of flavonoids and sesquiterpene lactones from Lychnophora ericoides, a plant used in traditional medicine, and their evaluation against multiple myeloma and acute myeloid leukemia cell lines. Several compounds show first evidence of cytotoxic activity, exemplifying …
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Searching for Anticancer Natural Products From the Rainforest Plants of Suriname and Madagascar
… pachyclada led to the isolation of four new sesquiterpene lactones. Their structures were determined using mass spectrometry, 1-D and 2-D NMR, and (in one case) single crystal X-ray diffraction. All four compounds were cytotoxic in the A2780 human ovarian cancer cell line. Fractionation of an …
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Leishmanicidal, anti-inflammatory and anti-obesity properties of natural products from common medicinal and edible plants.
… The roots of C. intybus (chicory) yielded four sesquiterpene lactones: (1) 11(S),13-dihydrolactucopicrin, (2) lactucopicrin, (3) 11(S),13-dihydrolactucin and (4) lactucin. Only compound 2 presented leishmanicidal activity (IC50 24.8 μM). The bark of C. florida (flowering dogwood) afforded eight …
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
… GSH. The interaction of tumor cell GSH with four sesquiterpene lactones (SLs), a class of sulfhydryl-reactive antineoplastic agents, was evaluated. SLs are potent depletors of cellular GSH. Prompt resynthesis of GSH is a critical component of tumor cell recovery following exposure to SLs. …