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Showing 1 to 20 of 49 for “"sesquiterpene"”.
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Synthesis of sesquiterpene-tropolones
… for the synthesis of the multi-bioactive sesquiterpene-tropolone natural products has been developed in an effort to provide general synthetic access to this class of compounds and related structures. In this work, the convergence of the sesquiterpene and tropolone fragments is enabled by …
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Unique approaches towards the synthesis of polycyclic sesquiterpene targets
A programme of work towards the total synthesis of the natural product sesquithuriferone has been performed, with significant advances towards the realisation of this overall goal achieved. From this perspective, two main synthetic strategies have been investigated towards the synthesis of a common …
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Studies on the anti-cancer potential of sesquiterpene lactone parthenolide
Parthenolide is the major sesquiterpene lactone responsible for the bioactivities of Feverfew (Tanacetum parthenium), a traditional herbal medicine which has been used in treatment of fever, migraine and arthritis for centuries. This compound has long been known to have potent anti-inflammatory …
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Contribution to the elucidation of the anti-inflammatory activity of Sesquiterpene Lactones
To analyze the mechanism by which sesquiterpene lactones (SLs) inhibit DNA binding of the transcription factor NF-kB, the role of cysteine residues in its DNA binding domain was tested using single amino acid mutants of the p65 subunit. The results confirm that p65 is alkylated by SLs, and that the …
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Identification and Functional Characterization of Sesquiterpene Pheromone Biosynthetic Genes in Stink Bugs (Pentatomidae)
… we provide evidence that Pentatomidae produce sesquiterpene aggregation pheromones de novo and discuss the evolution of terpene biosynthesis in stink bugs. According to transcriptome analyses, the investigated stink bug species express at least two isoprenyl diphosphate synthases (IDSs), one of …
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I. Total synthesis of sesquiterpene-tropolones II. Dearomative hydroamination and application to the synthesis of aminoglycosides
The student, Chad Ungarean, accepted the attached license on 2020-12-01 at 04:52.
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Natural Variability in Phenolic and Sesquiterpene Constituents Among Burdock (<i>Arctium lappa</i> L. and <i>Arctium minus</i> L.) Leaves for Potential Medicinal Interests
<p><i>Arctium lappa</i> and <i>Arctium minus</i>, commonly known as burdock, are introduced, feral, biennial species found throughout the United States. Native to Europe, these plants have been valued for centuries for their medicinal properties and/or as part of a healthy diet by both western and …
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Introgression of the Genes for Sesquiterpene Carboxylic Acid Synthesis From a Wild Tomato, Lycopersicon Hirsutum, Into the Cultivated Tomato for Increased Host -Plant Resistance to Insect Pests
… of the markers with a TA517 line that produces sesquiterpene precursors to SCA revealed three markers putatively associated with synthesis of the olefin to SCA and six putatively associated with modifications to SCA.
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Role of Subcellular Differentiation in Plant Disease Resistance
… active HMG2 in mediating these changes. Sesquiterpene cyclase (a key branch point enzyme controlling sesquiterpene phytoalexin biosynthesis) was not induced and the amount of capsidiol, the tobacco phytoalexin, was not elevated by expression of hmg2. After TMV-inoculation, HMGR activity …
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Characterization of Molecular Content, Cytotoxicity, and Anti-Inflammatory Activity of Extractions from Eupatorium serotinum
… difficulty of motion. Recently, the effect of sesquiterpene lactones such as Helenalin from <em>Arnica montana</em> have been studied for their anti-inflammatory properties. In this study, we identified and harvested samples of <em>Eupatorium serotinum</em>, a plant historically used by Native …
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Characterisation of sandalwood essential oils using high performance thin-layer chromatography and high resolution gas chromatography mass spectrometry
… influence the oil quality. Variation in sesquiterpene composition and oil yield have been observed both within and across Santalum species. Gas Chromatography-Mass Spectrometry (GC-MS) is a technique commonly used to identify and quantify sesquiterpene compounds in sandalwood essential …
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Action of Allelochemicals on Algal Growth and Photosystem Ii Efficiency
… 1 μM. The growth-inhibition threshold for other sesquiterpene lactones, alkaloids, coumarins, flavonoids, and quinones ranged between 10 and 100 μM. The inhibition threshold was 100 μM or higher for benzoic and cinnamic acids. Sesquiterpene lactones were PSII inhibitors that had a positive …
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Time Dependent Uptake of Volatile Organic Compounds on Silica and the Observation and Quantification of Ambient Sesquiterpenes in Virginia
… was observed to increase from isoprene to sesquiterpenes, with several monoterpene isomers exhibiting distinct adsorption behavior based on structural differences. The sesquiterpene examined, β-caryophyllene, exhibited continuous uptake onto the silica surface and such uptake behavior could …
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Aggregation Pheromone Biosynthesis and Engineering in Plants for Stinkbug Pest Management
… specialist pest on crucifer crops, produces the sesquiterpene, murgantiol, as a male-specific aggregation pheromone. Similarly, the southern green stink bug, Nezara viridula, a generalist pest worldwide on soybean and other crops, releases sesquiterpene cis-/trans-(Z)-α-bisabolene epoxides as …
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Structure, Function and Applications of Metal-Requiring Enzymes: Carbonic Anhydrase and Epi-Isozizaene Synthase
… of recombinant epi-isozizaene synthase (EIZS), a sesquiterpene cyclase from Streptomyces coelicolor A3(2), has been determined at 1.60 Å resolution. Specifically, the structure of wild-type EIZS is that of its closed conformation in complex with three Mg2+ ions, inorganic pyrophosphate (PPi), and …
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Insecticidal Natural Products From Sri Lankan Plants
… <br></br><br></br> Three new macrocyclic sesquiterpene polyol ester alkaloids 1, 2 and 3 containing a novel 6,7 ring skeleton have been identified from the petroleum ether-ethyl acetate extract of the stem bark of <i>Pleurstylia opposita</i>. They are homologues of known macrocyclic …
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Studies towards the synthesis of the guaianolide and pseudoguaianolide skeleton
… thesis. Guaianolides and pseudoguaianolides are sesquiterpene lactones and share a sommon backbone: the guaiane skeleton. Hundreds of natural products belong to these families of compounds. The guaiane skeleton is characterised by a bicyclo[5.3.0]decane ring system (perhydroazulene). Among the …
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Vinylcyclopranes comme précurseurs de diènes dans la condensation de Diels-Alder
… a l’ouverture de la moitié cyclopropanique du sesquiterpene ete etudie. Pour faire ceci, les diènes formes suite à des réarrangements ont été piégé avec l'aide d'une réaction de Diels-Alder en utilisant l'anhydride maléique comme diénophile en mode thermique ou active par micro-ondes. Une …
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Quantitative analysis of active compounds found in Arnica montana and Arnica chamissonis in relation to varied provenance, environmental and agronomic factors.
… extract contained approximately a third of the sesquiterpene lactone content.
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Synthetic Investigation of Natural Products Causing Dopaminergic Neurodegeneration
… The polyketide SV-6 from S. venezuelae and the sesquiterpene lactone repin from R. repens both produce dose-dependent and selective degeneration of dopaminergic neurons. These molecules represent two possible tools that can be used to explore chemotoxic induction of Parkinson’s disease. In the …
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