Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"serum response"”.
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Serum response factor-dependent regulation of smooth muscle gene transcription
… to the proliferative/dedifferentiated one. Serum response factor (SRF) is the major transcription factor that plays an essential role in coordinating a variety of transcriptional events during this phenotypic change. The first goal of my thesis studies is to determine how SRF regulates the …
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Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
… but were deficient in glial specification in response to several pro-astrocytic or pro-oligodendrocyte signals in vitro. Similarly, we observed an increase in the number of proliferative cells in the ventricular zone from embryonic day 14 to day 18, suggesting that SRF-deficient precursor …
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Overexpression of Serum Response Factor in Astrocytes Improves Neuronal Plasticity in a Model of Fetal Alcohol Spectrum Disorders
… transcription factors such as the cAMP response element binding protein (CREB) and the Serum response factor (SRF). SRF is important for many plasticity processes such as LTP, LTD, spine motility and axonal pathfinding. Here we attempt to rescue OD plasticity in alcohol-treated ferrets …
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Zinkserumresponse beim Pferd nach oraler Verabreichung von unterschiedlichen Zinkverbindungen
Summary In the here presented study, the zinc serum response was investigated after the application of 4 different zinc compounds with varying dosages. To be able to consider species differences, dogs and cats were also supplemented with the same compounds and the zinc serum values measured. A …
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Comparative analysis of the promoters of the CyI-CyIIa-CyIIb actin gene cluster in the sea urchin Strongylocentrotus purpuratus
… while CyI and CyIIb share an identical CArG (or serum response element) and extensive sequence homology in the upstream region, homology with CyIIa is essentially limited to consensus protein binding sites, including the serum response element (SRE) and an octamer motif. Along with several other …
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Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
… of quiescent cells into the cell cycle following serum stimulation. These genes are involved in growth control and differentiation and hence their expression is tightly controlled. Many IEGs are regulated through Serum Response Elements (SREs) in their promoters, which bind Serum Response Factor …
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Regulation of Inverted Formin-1 (INF1) by Microtubule-Affinity Regulating Kinase 2 (MARK2)
… able to induce F-actin formation, activate the Serum Response Factor (SRF) pathway, stabilize microtubules, associate with microtubules, and disperse the Golgi body. Regulation of INF1 is unique, since it does not possess conserved formin regulatory domains. However, INF1 does possess many …
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Identification and characterization of GRP50 : a novel Golgi-associated ankyrin repeat protein
… in adult brain, and is induced as part of the serum response in cultured primary fibroblasts. Sequence analysis indicates that GRP50 encodes a medium-sized protein with multiple modular domains, including an ankyrin repeat region, a polyproline-rich region, and a leucine-rich region that may …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
… Bioinformatic analysis reveals an enrichment of serum response factor (Srf) targets amongst genes upregulated following Lats1/2 deletion. Ablating Srf in the Lats mutant background causes Lats;Srf mutant cells to undergo epithelial to mesenchymal transition but not progress to fulminant tumors in …
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Transcriptional Regulation of the Xenopus MyoD Gene
… by transgenic reporter analysis. XSRF (Xenopus serum response factor) binds with the maintenance enhancer to maintain the expression of XmyoD gene. A repetitive DNA sequence was discovered in the -2.8/-2.0kb region in the XmyoD genomic sequence. The repetitive DNA sequence in the XmyoD gene …
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Estrogen action in the myocardium
… of an estrogen target gene, the early growth response gene-1 (Egr-1) and 3) to initiate the search for novel estrogen target genes in the myocardium. 1) The effects of estrogen on the expression of one of the major myocardial specific contractile proteins, the alpha-myosin heavy chain …
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… the in vivo relevance of the partnership between Serum response Factor (SRF) and its Myocardin Related Transcription Factor (MRTF) coactivators during development. I present here my studies on the functions of MRTFs during brain and muscle development. First, I show that MRTF-A and -B redundantly …
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Construction of CNFY-CNF1 Chimera Protein for Study of Differential pH Dependent Activity of CNF Proteins
… as well as direction to begin testing. Using serum response element (SRE) has been seen as an effective way to test cellular activity for PMT and CNFs. In this thesis, we focus on the construction of CNF chimeras so that SRE-based reporter tests may be conducted in future studies.
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Investigations of collective cell movement during gastrulation in the chick embryo
… mesendoderm trajectories. However, the cellular responses were assessed in vivo and due to the complexity of the environment, they could not be fully interpreted. This is because the introduced ligands might have triggered the secretion of secondary factors to which the cells responded. In the …
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The identification of prostate cancer associated tumour antigens and biomarkers
… spectrometry) with serological screening using serum antibodies, to identify immunogenic proteins in cancer. This project aims to identify TAAs and/or biomarkers for PCa which on subsequent validation, can be utilised as an improved diagnostic screening test. In pilot studies, SDS PAGE, 2-DE and …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… factor-β (TGF-β), to promote tissue repair. In response to these biochemical cues, VF fibroblasts undergo a fibroblast-to-myofibroblast transition. While myofibroblasts are required for wound closure and VF repair, persistent myofibroblast activation results in the over-accumulation of a …
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Genetic effect of histamine N-methyltransferase (HNMT) polymorphism on chronic urticaria with aspirin hypersensitivity
… cell line (p < 0.05). Transcription factor, serum response accessory protein-1 (SAP-1), was bound to the HNMT -465C allele probe (-477/-454) with higher affinity than that of the -465T allele probe. The 939A>G polymorphism was significantly associated with the AICU phenotype. The functional …
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Erforschung des Beitrags des MAPK- und STAT-Signalwegs an der EGF-vermittelten Aktivierung der c-fos-Gen-Expression
Das c-fos-Gen enthält eine Vielzahl regulatorischer DNA-Bindestellen in seiner Promotor-Region. Diese Promotor-Elemente sind entscheidend an der spezifischen Antwort zu verschiedenen Umweltreizen, denen Zellen im Körper ausgesetzt sind, beteiligt. Die Stärke der c-fos-Gen-Expression ist abhängig …
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The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors
… rates and increased levels of CYCLIND1 in a serum dependent manner when compared with wild type MEF cells. The reduced proliferation in wild type cells was mediated through up-regulation of CYLD by transcription factor serum response factor (SRF) in a p38 mitogen-activated protein kinase …
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