Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"serum resistance"”.
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Association of <i>glpQ</i> with serum-resistance in <i>salmonella typhimurium</i>
… when it escapes into the bloodstream. The human serum complement system is central in fighting systemic bacterial infections. <em>S. typhimurium</em> exhibits resistance to killing by complement (serum-resistance), a trait conferred by several known virulence genes. This study investigates a …
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The capsular polysaccharide of Actinobacillus pleuropneumoniae serotype 5A: role in serum resistance and characterization of the genetic basis for expression
… K17 was killed in precolostral calf serum (PCS) but not in normal serum used as a complement source. In contrast, two capsule-deficient mutants were killed in normal serum. The CP of A. pleuropneumoniae contributed to serum-resistance by limiting the amount of C9, a component of the …
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Physiological characterisation of the neonatal meningitic bacterium Cronobacter sakazakii
… desiccation stress, heat tolerance, acid resistance and serum resistance assays. The desiccation and serum resistance assays indicated that all of the tested C. sakazakii CC4 and non-CC4 strains showed equal resistance against desiccation and serum. The experiments also indicated that C. …
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The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
… bacterial surface and increased the bacterial serum-resistance. Furthermore, we identified a novel surface-exposed virulence factor designated Haemophilus Protein F that also sequesters vitronectin on the surface of the bacteria, thus rendering the pathogen more serum-resistant. Moreover, we …
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Determining the fitness and competitive advantage of the epidemic ExPEC clone E. coli ST131
… lineage and associated with fluoroquinolones resistance and CTX-M-15 production. Our data identified the presence of 150 loci unique to ST131 H30Rx strains, and the most striking finding at a genomic level was the identification of the secondary flagellar locus Flag 2 as a region uniquely …
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Genetic analysis and characterisation of the BapC autotransporter of bordetella pertussis
… work has suggested that BapC, like BrkA, is a serum-resistance factor. B. pertussis brkA, bapC double and bapC single mutants were created, and showed greater sensitivity to killing by normal human serum than their wild-type strains but they were not as sensitive as a bvg mutant strain. …
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Analysis of plasminogen binding to Treponema denticola, a key periopathogen
… that the primary mechanism of T. denticola serum resistance is binding of the human complement regulatory protein, Factor H (FH), to the factor H-binding protein (FhbB). FH serves as cofactor in the Factor-I mediated cleavage of C3b and accelerates the decay of the C3 convertase complex, …
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Prevalence of human African trypanosomiasis and its associated risk factors in Itezhi-tezhi district of Zambia.
… microscopy, internal transcribed spacer (ITS)/serum resistance antigen (SRA) polymerase chain reaction (PCR) and SRA loop mediated isothermal Amplification (SRA-LAMP). Structured questionnaires collected data on risk factors as well as the district’s health delivery system through patients and …
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Role of new virulence mechanisms/factors (type 3 secretion system and TOX-R regulated lipoprotein [TAGA]) in the pathogenesis of the emerging human pathogen Aeromonas hydrophila
… at the cell surface, ultimately increasing the serum resistance of the pathogen. TagA can also target C1-INH to erythrocyte surfaces and decrease the lysis that occurs in the presence of serum. Confocal fluorescence microscopy revealed that the serpin C1-INH binds to TagA on the surface of the …
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The role of Moraxella catarrhalis outer membrane proteins in pathogenesis
… method for purification of ACT from plasma or serum based on ACT affinity to a fragment of UspA2 protein of M. catarrhalis. The purification can be carried out practically in one step and the biological properties of ACT are retained. In the last part of the thesis the C3 binding to M. …
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Mechanismen der Serumresistenz von Serogruppe A Meningokokken unter besonderer Berücksichtigung der Kapsel und des Lipopolysaccharids
… Krankheit assoziiert sind. Krankheitsisolate aus Serum oder Liquor sind fast ausnahmslos bekapselt, während Trägerisolate, die aus dem Nasopharynx von ca. 10% der gesunden Bevölkerung isoliert werden können, häufig unbekapselt sind. Das Komplementsystem, das einen wichtigen Abwehrmechanismus gegen …
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Studies on the architecture and on transferability of pathogenicity islands of uropathogenic Escherichia coli strain 536
… and the use of a K15 capsule-specific antiserum demonstrated that this determinant is the functional K15 capsule locus of strain 536. It has been shown in an experimental murine model of ascending urinary tract infection with suckling mice that the K15 capsule contributes to urovirulence. …
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Design of hybrid retroviral/synthetic gene delivery vectors
… any transfections with M-VLPs. χ/M-VLPs were serum resistant and also provided stable transgene expression over three weeks. χ/M-VLP suffered from high precipitation issues when stored at 4 °C for > 4 days but exhibited better transfection efficiency than MLV-A in the same testing period. Both …
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Early pathogenesis of Yersinia ruckeri infections in rainbow trout (Oncorhynchus mykiss, Walbaum)
… and intracellular survival in cell lines and serum resistance. The adhesion and invasion mechanisms were further characterized for selected Y. ruckeri strains. The virulent isolates highly adhered to isolated gill and gut mucus of rainbow trout, whereas the majority of the avirulent strains …