Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"serum biomarkers"”.
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Novel Serum Biomarkers For Lung Cancer Early Diagnosis and Clinical Outcome
… 40 years. Despite the tremendous efforts made, serum biomarkers with clinical utility for lung cancer early detection and clinical outcome prediction are still lacking. Metabolic alterations have been recognized as an emerging hallmark of cancer. We aimed to investigate the metabolic changes …
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Magnetic resonance imaging and serum biomarkers of traumatic brain injury – methodological and clinical considerations
… resonance imaging (MRI) and development of serum protein biomarkers have created an opportunity to gain new insights into the recovery after TBI. This thesis aimed to understand the role of MRI and serum biomarkers for outcome prediction after TBI. Before this clinical question could be …
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Muscular Strength Training Modifies Regulation of Bone Remodeling: Inferences From Serum Biomarkers in Young Women
… earlier than densitometric technologies. Serum concentrations of receptor activator for nuclear factor kappa-beta ligand (RANKL), osteoprotegerin (OPG), osteocalcin, and N-telopeptide (NTx) were measured in women aged 20 + 1.5 years (mean + SD) who underwent 32 weeks of unilateral …
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Dietary and Serum Biomarkers, and Glycaemic status: Relationships with Type 2 Diabetes Mellitus and Incident Dementia
… were (1) to investigate associations between serum biomarkers and glycaemic status in older Australians using traditional and machine learning methods (2) to examine how daily dietary intake, serum biomarkers, and glycaemic status predict dementia progression over 14 years and (3) to assess …
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The effect of freeze-dried whole blueberry powder on joint flexibility, mobility, and serum biomarkers of cartilage metabolism in symptomatic knee osteoarthritis
… powder on joint flexibility, mobility, and serum biomarkers of cartilage metabolism in men and women ages 45-79 years old with symptomatic knee osteoarthritis. Methods: A total of 63 participants were recruited and randomized into two groups. The freeze dried blueberry powder (FDBP) group …
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The effects of whole pureed mango intake on serum biomarkers of muscle damage in response to moderate intensity aerobic exercise in sedentary adults
… of whole pureed mango on cycling performance and biomarkers of muscle damage following exhaustive exercise in healthy sedentary young adults. Methods: A 10 week randomized, placebo-controlled cross-over study was conducted. Participants consumed a mango puree or placebo product daily for 4 weeks …
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Human aflatoxin exposure in south-western Ethiopia assessed using serum biomarkers: A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Science at Lincoln University
… in South-western Ethiopian adults, using serum biomarkers. The study was conducted in five South-western Ethiopian rural districts (Shebe Senbo, Manna, Seka Chekorsa, Kersa, and Omo Nada) in the Oromia Region and included 100 adults aged 18–60 years. The 100 serum samples collected were …
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Clinical utility of 3D power doppler ultrasound and maternal biomarkers in the prediction of pre-eclampsia in high-risk pregnancies
… medical history, ultrasound parameters and serum biomarkers may be of use in defining the patient-specific risk for pre-eclampsia.<br/><br/>Against this background, this thesis examines the ability of baseline maternal characteristics, placental vascularisation indices, uterine artery …
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The Role of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy
… phenotypes. Finally, I also hypothesize that serum biomarkers of perivascular fibrosis can be used to diagnose CAA following intracerebral hemorrhage (ICH). To test these hypotheses, I first performed experimental stroke in young and aged wild-type mice, then measured basement membrane …
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Effect of Low vs High Eating Frequency on Perceived Appetite, Plasma Appetite Hormones, and Appetite Relationships: A Component of the Frequency of Eating and Satiety Hormones (FRESH) Study
… impact of eating frequency on self-reported and serum markers of appetite. If self-reported measures of appetite and serum biomarkers are dysregulated, imbalanced caloric intake could occur, leading to related significant health problems. This study seeks to identify whether three or six meals a …
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Cognitive, Clinical, and Biomarker Correlates of Insight in Obsessive–Compulsive Disorder: preliminary results of a cross-sectional study
… performance, sleep architecture, and peripheral biomarkers in OCD, integrating dimensional and machine-learning approaches. A multimodal dataset including psychometric scales (Y-BOCS, BABS), MATRICS-defined cognitive tests, polysomnography, and serum biomarkers (BDNF, TNF-α, CRP) was analyzed in …
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Exploring neurodegeneration in Ataxia-Telangiectasia
… disease phenotyping, and metabolic and imaging biomarkers limits the progress of developing curative treatments and successful clinical trials for this disease. This study focuses on trial readiness and exploring the neurodegenerative process in A-T. I have focused on the development of a …
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Untersuchung der relativen Serum-Trisialotransferrin-Konzentration als möglicher prädiktiver Biomarker für hepatozelluläre Dedifferenzierung bei chronisch fibrogener Lebererkrankung
… carcinoma (HCC). Up to now the spectrum of valid serum biomarkers for this process of hepatocellular dedifferentiation is very limited. Thus, we investigated the dynamics of alterations in the serum transferrin isoform pattern in the pathogenetic sequence from liver fibrosis to hepatocellular …
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Identify Signature Genes/Pathways to Characterize Alzheimer's Disease Subtypes Based on Uncoupled Tauopathies and Cognitive Decline
… prevention. By identifying specific molecular biomarkers associated with each subtype, I hope to help clinicians diagnose various AD subtypes at an earlier stage. In this work, I have performed transcriptomic and proteomic characterization of two atypical AD subtypes on two large AD/normal …
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Integrated imaging and circulating biomarkers for the assessment of drug-induced hepatotoxicity
… is usually based on exclusion using blood-based biomarkers for cell injury. Currently used chemistry parameters lack sensitivity, specificity and prognostic capability. More importantly, they provide little insight into the underlying mechanistic basis of DILI hindering stratification and …
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Application and Extension of Weighted Quantile Sum Regression for the Development of a Clinical Risk Prediction Tool
… is often aided by measurement of various serum biomarkers through the use of laboratory tests. These biomarkers provide information about different aspects of a patient’s health and the overall function of different organs. In this dissertation, we develop and validate a weighted composite …
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Mindfulness as a treatment for military women's chronic pelvic pain: A randomized controlled trial (MoCHI)
… on pain with the Brief Pain Inventory (BPI) and biomarkers specific for CPP, depression with the Patient Health Questionnaire (PHQ-9), and inflammation with serum biomarkers before and after the interventions. Demographic data and mindfulness were also measured. iv Findings: Twenty-eight of the …
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Utilizing pQCT and Biomarkers of Bone Turnover to Study Influences of Physical Activity or Bariatric Surgery on Structural and Metabolic Status of Bone
… DXA measures; 3) 6-month time course changes on serum biomarkers of bone turnover and associated adipokines induced by AGB vs. RYGB. Methods: Standard DXA and pQCT measurements were taken for all subjects. PA tertiles (PA-L, PA-M, PA-H) were based on a calculated average MET-min/day determined …
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A novel approach to the clinical diagnosis and treatment of canine histiocytic sarcoma
… protocol in cell culture, and potential use of serum biomarkers in monitoring response to treatment. The use of different IHC markers on formalin fixed tissue samples were evaluated in their ability to differentiate HS from soft tissue sarcomas. Initially a dendritic cell marker, CD206, was …
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Identification of Circulating MicroRNAs as Biomarkers in Glioblastoma
… the circulation of patients provides a source of biomarkers which could be utilised in a relatively non-invasive diagnostic test. The primary aim of this thesis was to identify secreted biomarkers in biofluids of glioblastoma patients for the diagnosis and prognosis of glioblastoma mulitforme …
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