Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"serum amyloid P-component"”.
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… <p>The immunization of DNA-containing amyloids into non-autoimmune mice triggers the activation of pDCs and induction of lupus-like disease, characterized by the production of autoantibodies. Using this lupus model that is dependent on pDC activation and IFN-I production, we delineated …
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An investigation into the effects of inorganic element status on the accumulation and deposition of amyloid in various diseases.
… diseases are reported to be associated with amyloidogenic peptides and proteins, for example, β amyloid (Αβ) in senile plaques of Alzheimer's disease and β2 microglobulin (β2M) deposition in dialysis related amyloidosis. The major factor for amyloidosis appears to be an increase in the …
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Protein mis-folding and human disease
Serum Amyloid P Component (SAP), a putative molecular chaperone, is a homopentameric<br/>plasma protein of 25kDa subunits. It binds to the amyloid fibrils of<br/>misfolded proteins, which cause amyloidosis in humans. SAP not only stabilizes<br/>amyloid fibrils but also protects them from …
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The Development and Implementation of a TMT-SRM Assay for the Validation of Candidate Biomarkers of Alzheimer’s Disease
… macroglobulin, gelsolin, fibrinogen gamma-chain, serum amyloid p-component and complement factor H. These proteins were previously found to be differentially expressed between plasma of Alzheimer’s disease subjects and non-demented controls. Additionally, apolipoprotein E4 was included in the …