Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"serous"”.
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Comparison of Survival between Patients with Serous Fallopian Tube carcinoma and Serous Adenocarcinoma of the Ovary
… case–control comparison. Fifteen patients with serous fallopian tubal carcinoma were identified on Ajou university medical center from September 1994 to December 2008. Thirty-one with ovarian carcinoma were identified for each fallopian tube carcinoma patients based on age, parity, BMI, stage, …
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Augmented Radiology in High Grade Serous Ovarian Carcinoma
Radiological imaging is at the centre of how modern medical care is delivered and provides a unique perspective on disease: it is non-invasively attained, gives 3-dimensional spatially resolved information about disease, and when images are captured sequentially, allows for temporal comparison. …
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Roles of PKR in High Grade Serous Ovarian Cancer
High-grade serous ovarian carcinoma (HGSC) is characterized by dissemination within the peritoneal cavity, a process that critically depends on dynamic regulation of cell adhesion, migration, and invasion rather than primary tumor growth. Protein kinase R (PKR; EIF2AK2) is classically described as …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
<p>High Grade Serous Ovarian Cancer (HGSOC) can be classified by gene copy number signatures into 7 subtypes that have differing prognoses and treatment sensitivities and that show differences in the activities of various signalling pathways. An ongoing clinical study has demonstrated the …
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Adjuvant methods to identify and type tumor cells in serous effusions
… diagnostic challenges of cytopathology in serous effusions. It may be overcome by the application of adjuvant methods. The current study investigated the usefulness of cytology, DNA-image cytometry (DNA-ICM), immunocytochemistry, AgNOR-analysis, and chromosomal fluorescence in situ …
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Improving earlier non-invasive diagnosis of high-grade serous ovarian cancer
… tumour DNA (ctDNA) biomarker for high grade serous ovarian cancer (HGSOC), was to investigate low-cost high-throughput next generation sequencing assays in plasma samples collected from women with newly diagnosed OC. The secondary aim was to apply these methods to other non-invasive samples …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… of immune cell abundance in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave imprints of copy-number aberrations …
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The Role of Luteal Phase Fallopian Tube Epithelium in High-grade Ovarian Serous Carcinoma
… at risk for tubal and ovarian high-grade serous carcinoma (SerCa), have consistently revealed occult carcinomas and putative histological cancer precursors in the distal fallopian tube epithelium (FTE), supporting the FTE as the source of SerCa. In this thesis I molecularly characterized …
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Combination Chemotherapy and In vivo Modeling of BRCA-deficient, High-grade Serous Ovarian Cancer
… profound synergism in BRCA-deficient high-grade serous ovarian cancer cell lines when carboplatin was administered at a higher molar ratio relative to olaparib. The combination achieved effective cytotoxicity by inducing greater DNA damage than either of the drugs alone. Synergism of …
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Mitochondrial Quality Control Adaptations Support Malignant Progression of Serous Ovarian Cancer Cells and Spheroids
Serous ovarian cancer is the 5th leading cause of cancer-related deaths in women, with a 30% survival rate when spread into the highly hypoxic and visceral peritoneal cavity. Despite efforts to treat this highly metastatic disease, traditional chemotherapeutic and cytoreductive therapies are unable …
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Phenotypic heterogeneity in high-grade serous ovarian cancer: evidence for a stochastic model of proliferation
High-grade serous ovarian cancer (HGSOC) represents the largest and most lethal subtype of ovarian cancers. Chemotherapy is effective at depleting these tumours, sometimes eliminating all visible disease, however the tumour invariably regrows from surviving tumour cells. Improving treatment depends …
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Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer
… architecture that underlies them in high grade serous ovarian cancer (HGSOC). The quantitative distribution of three key immune infiltrates was initially assessed in the SEARCH cohort (n=332); CD8+ cytotoxic T-cells, CD45RO+ memory T-cells and CD68+ macrophages. The stromal infiltration of CD68+ …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… studies showed that BRCA-deficient high grade serous ovarian carcinoma (HGSOC) had increased tumor infiltrating lymphocytes (TILs) compared to BRCA-wildtype (WT). To better understand the underlying immune mechanism in these tumors, a preliminary transcriptome analysis was performed on a set of …
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Fully Automated Segmentation of High Grade Serous Ovarian Cancer on Computed Tomography Images using Deep Learning
… the fully automated segmentation of high grade serous ovarian cancer. The recent rise of deep learning has pushed the limits of what algorithms can achieve in fields of image analysis, such as the task of segmentation. The field of medical image segmentation has fundamentally changed, and it is …
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Unravelling the Spatial and Temporal Heterogeneity of High-Grade Serous Ovarian Cancer Using Imaging-Based Biomarkers
High-Grade Serous Ovarian Cancer (HGSOC) is the most prevalent and lethal subtype of ovarian cancer, characterised by significant spatial and temporal heterogeneity, which has been linked to poor survival outcomes. In this challenging landscape, the quest to characterise heterogeneity through …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
Ovarian high-grade serous carcinomas (HGSC) are the most common and fatal histological subtype of ovarian cancer, characterised by late stage diagnosis and high mortality rates. Unfortunately, the majority of patients (> 85%) will develop fatal chemoresistant disease despite multiple lines of …
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Cyclin B1 Mediates The Effect of Uchl1 In Promoting Cell Cycle Progression In Uterine Papillary Serous Carcinoma
<p>Uterine papillary serous carcinoma (UPSC) is an aggressive form of endometrial cancer with poor survival rates and a high risk of recurrence. The rarity of UPSC poses challenges to the discovery of novel targeted therapies. Therefore, the purpose of this dissertation was to identify novel …
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Investigating lipid metabolism and gene expression in High Grade Serous Ovarian Cancer (HGSOC) disease progression and chemoresistance
HGSOC is the most common and deadly form of ovarian cancer and is characterised by vague symptoms, late diagnosis and a high level of metastasis. While most patients initially respond well to the current standard of treatment – tumour debulking surgery and platinum/taxane combination chemotherapy – …
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ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS
High-grade serous ovarian cancer (HGSOC) is a highly heterogeneous and aggressive malignancy characterized by marked inter-/intra-tumor variability and a dynamic tumor microenvironment (TME). The TME, and particularly ascitic fluid (AF), plays a critical role in OC progression by influencing tumor …
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