Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"serotonin transporter"”.
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Serotonin transporter import
… neurotransmission and members of this family of transporters are a popular target in the treatment of depression, addiction, obsessive compulsive disorder, and generalized anxiety disorder including the serotonin transporter and the dopamine transporter. These transporters have been the targets …
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Characterization of an Evolving Serotonin Transporter Computational Model
… structure and function of a central target, the serotonin transporter (SERT). Established SERT inhibitors (SSRIs) were docked to an in silico SERT model to identify likely binding pocket amino acid residues. When mutated singly, no one of five implicated residues was critical for high affinity in …
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Neurochemische und autoradiographische Untersuchungen von Serotonin-Transporter-Knockout-Mäusen
Um die Auswirkungen der allelischen Expressionsvariabilität des 5-HTT auf das Gehirn zu untersuchen, wurde eine transgene 5-HTT-Knockout-Maus entwickelt, die als Grundlage der Untersuchungen der vorliegenden Arbeit diente. Vor allem aufgrund der Assoziation des kurzen Allels des …
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Pharmacological Characterization of Novel Serotonin Transporter Inhibitors Identified Through Computational Structure-Based Virtual Screening
… population diagnosed as of 2017. The selective serotonin reuptake inhibitors (SSRIs) have been the mainstay of pharmacotherapies for depression for the last 40 years. The SSRIs target the serotonin transporter (SERT), a monoamine transporter (MAT) responsible for terminating serotonergic …
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Impact of the Serotonin-Transporter-Polymorphism (5-HTTLPR) and Stressful Life Events on the Stress Response in Humans
The 5-HTT gene (SLC6A4) is regulated by a common polymorphism in the promoter region (5-HTTLPR), which has functional consequences. Two major alleles have been observed and shown to have differential transcriptional activity with the long (L) allele having greater gene expression than the short (S) …
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An exploration of the relationship between autism spectrum disorders, theory of mind and the serotonin transporter promoter length polymorphism
… underlying the socia l deficits in ASD. The serotonin transporter promoter length polymorphism (5 - HTTLPR) has been implicated in ASD, and as serotonin is implicated in social functioning more generally, it is possible that 5 - HTTLPR could underlie social functioning in ASD. As such, ToM …
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Impact of genetic variability in the serotonin transporter, Tryptophan Hydroxylase-2, and Serotonin 2A Receptors on MDMA Use and Impulsivity
… physical and psychological consequences. The serotonin (5-HT) system plays a prominent role in the neurochemical and behavioral effects of MDMA, and preferentially targets 5-HT neurons in humans, although this substituted amphetamine does have significant actions on other monoamine systems. …
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The serotonin transporter gene (SLC6A4) shows differential regulation between children with ASD and typically developing children in a South African population
… with ASD, and the differential expression of the serotonin transporter gene (SLC6A4) is linked to particular ASD traits. This study focuses on a length polymorphic repeat region (5-HTTLPR) upstream of the SLC6A4 promoter, and SLC6A4 promoter DNA methylation. The short variant of 5-HTTLPR is …
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Mechanisms Underlying the Adverse Consequences of Stress: A Role for the Dynorphin/Kappa Opioid Receptor System, p38α MAPK, and the Serotonin Transporter
… increases the surface expression of the serotonin transporter (SERT) specifically in the ventral striatum in a GRK3 and p38α MAPK dependent manner, and hypothesize that this regulation leads to a hyposertonergic tone. Future work elucidating the downstream effects of hyposerotonergic tone …
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Serotonin receptor mechanisms in anti-depressant action
Serotonin neurones have been implicated in the pathophysiology and treatment of clinical depression to a greater degree than any other neurotransmitter. Additionally, serotonin pathways may playa role in the pathophysiology and treatment of eating disorders, anxiety states and schizophrenia. …
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Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
… and evaluated for in vitro dopamine and serotonin transporter affinities. These unique 3ƒÀ-aryl-3ƒ¿-arylmethoxytropane analogues incorporated the structure of dopamine selective 2-substituted-3-phenyltropanes and the design of serotonin selective meperidine derivatives. In general, the …
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Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)
… been shown to have potent binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective reuptake …
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Serotonin and Threat: from Gene to Behaviour
… emotions associated with threat than others? As serotonin has been implicated as a key neuromodulator of emotion, the thesis addresses this question by adopting a multi-systems approach to investigate the link between serotonin and both threat-driven behaviour and trait anxiety with the common …
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PET-imaging in depression and antidepressant therapies : focus on the serotonin system and the cerebral glucose metabolism
… tomography to investigate the role of the serotonin transporter in depression and antidepressant therapies. Hereby, several studies were performed using the PET radiotracer [11C]DASB, which specifically targets the serotonin transporter. To allow qualitative and safe research with this …
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Cocaine Dependence: The Role of Serotonin Genes In
… The effects of pharmacological agents on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists promote the disruption of cocaine-associated memories. One measure of cocaine related cues in humans is …
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Pharmacological and Genetic Effects of Serotonin on Value-Based Decision-Making
… investigated the role of the neuromodulator serotonin on four different value-based decision making tasks, using an acute tryptopahin intervention and an associative genetic approach - a naturally occuring variation in the promoter region of the serotonin transporter gene (5-HTTLPR). …
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The effects of chronic ethanol self-administration on the serotonin system in monkeys
Serotonin plays an important role in mediating the effects of alcohol, but current serotonergic pharmacotherapies for alcoholism have had only modest success. Serotonin's effects on drinking are mediated at least in part by modulating neuroplasticity in the hippocampal formation. The hippocampal …
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Virtual Screening of Multi-Target Agents by Combinatorial Machine Learning Methods
… antidepressant agents of 7 target combinations (serotonin transporter paired with noradrenaline transporter, H3 receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT2C receptor, Melanocortin 4 receptor and Neurokinin 1 receptor respectively). COMBI-SVMs were compared to other VS methods in varies …
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Imputation of Microsatellite Markers With Tag SNPs
… 5-HTTLPR, in the promoter region of the serotonin transporter gene in a small sample of individuals from an ongoing neuroimaging genetics study, a portion of whom have both manual 5-HTTLPR genotypes and genome wide SNP data. We investigate four imputation methods: Tagger, Vertex …
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Adversity in early adolescence alters female rats' anxiety-related behaviours and serotonergic innervation profiles in adulthood
… was evaluated using immunohistochemistry for the serotonin transporter (SERT) in the medial prefrontal cortex (mPFC) and ventral hippocampus. Administration of IPS (i.e., water immersion, elevated platform, foot shock) in early adolescence increased rats’ anxiety-like behaviour in the elevated …
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