Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"serotonin receptors"”.
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Structure-activity relationships of serotonin receptors in isolated smooth muscle
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Pharmacological Characterization of Prejunctional Serotonin Receptors in Mammalian Anterior Uvea
Serotonin (5-hydroxytiyptamine, 5-HT) and its receptors have been demonstrated in ocular tissues including the cornea, iris-ciliary body and retina of various species. The overall objective of the present study was two-fold: (a) to examine the effect of exogenous 5-HT on the release of radiolabeled …
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Suppression of Machado-Joseph disease pathogenesis by serotonergic signalling: the contribution of serotonin receptors
… esta doença fatal. A modulação da sinalização serotoninérgica foi anteriormente descrita como potencial estratégia terapêutica para a DMJ. O tratamento com citalopram (CIT), um inibidor seletivo da recaptação de serotonina, suprimiu a patogénese da DMJ em vários modelos animais, sendo o efeito …
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Studies in GPCR and Chromosomal Control
… The first chapter is focused on regulation of serotonin receptors and signaling to address drug addiction, while the second chapter is focused on a novel synthetic approach towards a small molecule inhibitor of Ewing’s sarcoma. Drug addiction is a complex neurological illness that continue to …
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Serotonergic Signaling Pathways that Suppress Amyloid Beta in Mouse Models of AD
… for a direct sequence of signaling events from serotonin receptors to reduction of amyloid beta by alpha-secretase. Two serotonin receptors, 5-HT4R and 5-HT7R, reduce amyloid beta levels in the brains of transgenic mice that model Alzheimer's disease. These receptors are linked to activation of …
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Cocaine Dependence: The Role of Serotonin Genes In
… The effects of pharmacological agents on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists promote the disruption of cocaine-associated memories. One measure of cocaine related cues in humans is …
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5-HT3 Receptor Ligands and Their Effect on Psychomotor Stimulants
… produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the actions of psychomotor stimulants was analyzed in mouse locomotor activity assays to determine …
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Opiate Regulation of Lordosis: Neurochemical Evaluation of the Role of Opiate-Serotonergic Interactions
… turnover, but decreased the rate of serotonin turnover in the POA. These changes were not seen in other areas of the brain. Both naltrexone and morphine increased the rate of serotonin synthesis in the POA. The dissociation between the rates of serotonin synthesis and turnover is …
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Non-Neuroleptic Antitubercular and Anticancer Therapeutics through Rational Drug Remodelling of Phenothiazines and Related Antipsychotics
… series was screened for binding to dopamine and serotonin receptors to corroborate in silico CNS activity predictions. Moreover, pharmacokinetic studies were conducted with the selected series to determine in vitro microsomal stability, kinetic solubility and in vivo toxicity profiles. Another …
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Synthesis and Evaluation of C-10 Nitrogenated Aporphine Alkaloids at Serotonin and Dopamine Receptors
… of ligands for Central Nervous System (CNS) receptors. Previous research indicates that the aporphine scaffold may be manipulated to synthesize selective ligands for serotonin and dopamine receptors. Novel aporphine alkaloids containing C10 nitrogen substitutions were synthesized, and their …
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Neurotransmitter Modulation of Alcohol-Induced GABAergic Signaling in the Central Amygdala
… (OXT), corticotropin-releasing factor (CRF), and serotonin (5-HT) have demonstrated therapeutic potential in reducing alcohol-related behaviors. However, how these neuromodulators alter GABAergic transmission in the CeA and interact with alcohol, particularly at the circuit level, remains poorly …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
The role of the neurotransmitter serotonin (5-HT) in the taste bud is not well understood. Serotonin was long thought to be the neurotransmitter of taste signals from taste receptor cells (TRCs) to the gustatory afferent nerves, but the surprising discovery that this transmission is actually …
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The role of serotonin-2C receptors in the rat circadian system.
… of light information with activation of 5-HT2C receptors at night having a photo-mimetic effect. The studies described in this thesis aim to clarify the role of 5-HT2C receptors in the control of circadian rhythms in the rat model and compare their actions to light. The acute effects of 5-HT2C …
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5HT 2 Rezeptor vermittelte Kontrolle des neonatalen medullären respiratorischen Netzwerks des Säugers
Der Serotonin 2B Rezeptor (5HT 2B Rezeptor) ist ein wichtiger Regulator während der Embryonalentwicklung. Eine Inaktivierung des 5HT 2B Gens führt zu embryonalen und früh postnatalem tot bei Mäusen (Nebigil et al. PNAS 97:9508-13, 2000). Bis jetzt wurde noch kein Nachweis für funktionelle 5HT 2B …