Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"serotonergic"”.
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Serotonergic modulation of cognition
Action control arises from the interaction of two anatomically distinct decision-making systems, namely goal-directed and habitual behaviour. Goal-directed behaviour is characterized by the consideration of future choices and respective outcomes whereas habitual responding is driven by …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in monoaminergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. We found that conditional deletion of KOR from Slc6a4 …
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Neural Computation Through Synaptic Dynamics in Serotonergic Networks
… Second, I examined network computations in the serotonergic dorsal raphe nucleus through a dynamical lens, exploring the role of short-term synaptic dynamics at sparse recurrent connections, and of distinct long-range synaptic inputs, in shaping the output of spiking populations. 1. …
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Regulation of dorsal raphe serotonergic neurons by histamine
… and chemically defined brain structures. Serotonergic neurons located in the dorsal raphe nucleus (DRN) are currently accepted to be wake-promoting however their precise regulation by other neurotransmitter systems during the sleep-wake cycle is currently unknown. The main aim of this …
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Aspects of tic like behaviour and serotonergic control
… Pharmacologically, tics are modulated by serotonergic and dopaminergic systems and abnormalities of these systems have been reported in Tourette's Syndrome (TS). Therefore, serotonergic and dopaminergic modulation of tics induced by a thyrotrophin-releasing hormone (TRH) analogue were …
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Effects of serotonergic influence on ethanol consumption in rats
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Control of intertemporal choice by dorsal raphe serotonergic neurons
… is critical for survival. The dorsal raphe serotonergic neurons have been long implicated in the control of temporal discounting of reward [3] [4], but it is not clear whether their activities in fact direct the decision making process. In this thesis, I designed a cued intertemporal choice …
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Environmental enrichment and serotonergic alterations on depressive-like states in rats
Individuals suffering from depression primarily rely on pharmacological interventions to alleviate the incapacitating symptoms of the disorder. In addition to genetic differences underlying the etiology of depression, environmental factors play a key role as well. For example, environmental …
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Serotonergic involvement in the behavioral depression produced by intermittent swim stress
<p>Exposure to uncontrollable stress produces a behavioral syndrome that is often described as "behavioral depression" in the rat. Current paradigms for inducing behavioral depression utilize continuous swimming or intermittent electric shock stress. Brown et al., developed a novel strategy that …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… work has documented that taste cells respond to serotonergic stimulation, and that of the many serotonin receptors, taste buds express only the 5-HT1A and 5-HT3 subtypes. The 5-HT1A subtype was found to be expressed in TRCs, while the 5-HT3 subtype is presumed to be expressed in postsynaptic …
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Striatal Dopamine Release by Serotonergic Terminals in the Dopamine-Depleted Rat
… presence include remaining dopaminergic neurons, serotonergic terminals, and striatal intemeurons.</p> <p>Studies have shown that serotonin (5-HT) neurons are capable of DA synthesis following exogenous L-dopa administration. In addition, striatal hyperinnervation by serotonergic dorsal raphe …
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Prenatal stress alters fear-conditioned behaviors and the response to serotonergic drugs
Chronic, inescapable stress during pregnancy (i.e. prenatal stress) modifies the behavior of the adult offspring. Several behaviors were evaluated in adult prenatally stressed (PS) rats, most notably the acoustic startle response and behavioral inhibition (i.e. freezing). PS rats do not differ in …
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Serotonergic Signaling Pathways that Suppress Amyloid Beta in Mouse Models of AD
… avenue for slowing amyloid beta production is serotonergic signaling.</p> <p>This dissertation presents evidence for a direct sequence of signaling events from serotonin receptors to reduction of amyloid beta by alpha-secretase. Two serotonin receptors, 5-HT4R and 5-HT7R, reduce amyloid beta …
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Dissecting the Functional Heterogeneity of Serotonergic Systems That Regulate Fear and Panic
… (PeFR). Yet, our understanding of how specific serotonergic networks and co-transmitters regulate these conditions, but also other aspects of innate panic (e.g., car-dioexcitation or thermal response that occur during a flight or escape response) or condi-tioned fear behaviors is still elusive. …
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Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization
Rolle des 5-HT7/G12 Signalwegs bei der Morpho- und Synaptogenese. Der Neurotransmitter Serotonin (5-Hydroxytryptamin oder 5-HT) moduliert, zusätzlich zu seiner Funktion als Neurotransmitter, verschiedene Aspekte der frühen neuronalen Differenzierung, einschließlich des Neuritenwachstums und der …
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An analysis of behavioral and serotonergic mechanisms in male rat copulatory behavior
… those behaviors emerged which suggested that the serotonergic system may interact with the olfactory system to influence the two copulation factors.
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Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain
… severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance the rate of recovery of the neurons from the MDMA-induced effects. To …
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