Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"serogroup A"”.
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Synthesis of fragments of the capsular polysaccharide of <i>Neisseria meningitidis</i> (serogroup A) suitable for bioconjugation
One of the causative agents of meningitis is the gram-negative bacteria Neisseria meningitidis. In the region known as the African meningitis belt, N. meningitidis serotype A is endemic in the population and is also known to cause large scale epidemics. An important virulence factor of this …
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Molecular modeling of bacterial polysaccharide antigens to inform future vaccine development
… For N. meningitidis, our modeling indicates that serogroup A is unlikely to cross-protect against serogroup X infection, justifying the inclusion of serogroup X in future multivalent meningococcal vaccines. We also find that a chemically-stable carba-analogue of serogroup A has significant …
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Progress in the synthesis of stabilized glycoconjugate vaccine candidates against Neisseria meningitides group A
… in developing countries. Neisseria meningitidis serogroup A is among the leading causative agents of meningitis in Sub-Saharan Africa. Its capsular polysaccharide antigen consists of a homopolymer of a-(1
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Epidemiology and Control of Meningitis in Ghana: Application of Mathematical Modelling
… polysaccharide vaccine targeting N. meningitidis serogroup A (MenA), the predominant cause of epidemics. The vaccine was administered to the high-risk age group (1–29 years), resulting in no confirmed reported cases of MenA in the region since 2018. As part of enhanced global efforts to control …
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Reducing the Burden of Bacterial Meningitis in the African Meningitis Belt After MenAfriVac
… and multiennial epidemics. MenAfriVac, a serogroup A meningococcal conjugate vaccine, was introduced in mass campaigns in 2010 and has significantly reduced carriage and incidence of group A disease across the meningitis belt. However, other meningococcal serogroups and Streptococcus …
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Adherence to and invasion of mammalian cell lines by Pasteurella multocida B:2
… layer into the pulmonary interstitium. Avian serogroup A strains of P. multocida have been reported to invade cultured mammalian cells, but the behaviour of other of serogroups has not been reported. The main object of the work was to confirm that HS strains of P. multocida B:2 have the …
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Mechanismen der Serumresistenz von Serogruppe A Meningokokken unter besonderer Berücksichtigung der Kapsel und des Lipopolysaccharids
Neisseria meningitidis ist Auslöser der Meningokokkenmeningitis und der gefürchteten Meningokokkensepsis, die mit einer hohen Letalität belastet sind. Meningokokken lassen sich anhand ihrer Polysaccharidkapsel in verschiedene Serogruppen einteilen, wobei die Serogruppen A, B, C, W135 und Y mit …
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Molekulare Methoden zum Nachweis des oral-probiotischen Stammes Streptococcus salivarius ssp. salivarius K12 und Anwendung in vitro und in vivo
… A2. S. pyogenes, which is ß-hemolytic and in serogroup A, causes pharyngeal infections, particularly in children aged four to twelve, and occasionally complications as acute rheumatic fever and acute glomerulonephritis. To profit by the benefits of oral probiotic strain K12, it is important to …
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Using mathematical models to evaluate and inform immunisation strategies with MenAfriVac in the African meningitis belt
… burden of disease due to Neisseria meningitides serogroup A. The aim of this work is to identify immunisation strategies with MenAfriVac that best sustain population protection in the long-term and predict vaccine impact across all 26 meningitis belt countries. Firstly, I developed an …
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Pasteurella multocida biofilm formation, and the interrelationship of P. multocida with Histophilus somni in a polymicrobial biofilm during bovine respiratory disease
… is essential for CPS production in P. multocida serogroup A. Histophilus somni and Pasteurella multocida cause bovine respiratory disease (BRD) and systemic infections in cattle. Following respiratory infection of calves with H. somni, P. multocida is also often isolated from the lower …