Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"serine threonine kinase"”.
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Analysis of a bacterial serine/threonine kinase
RdoA is a bacterial protein kinase from Salmonella enterica serovar Typhimurium first noted for its regulation of dsbA expression in this organism. The crystal structure of RdoA’s homologue, YihE from Escherichia coli, revealed a basic bi-lobal kinase domain that is a hallmark of the eukaryotic …
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Functional analysis of syp1, a novel substrate of the serine/threonine kinase prk1
… Syp1p is a new substrate of Prk1p, a kinase that regulates actin dynamics. Syp1p colocalizes with actin cytoskeleton whose integrity is required for the polarized localization of Syp1p. Syp1p can physically interact with the actin-associated protein Sla1p. Furthermore, Syp1p …
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The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
The serine-threonine kinase mammalian target of rapamycin (mTOR) is an important integrator of nutrient, cytokine and growth factor sensing in T cells and controls transcriptional programs that determine CD8+ cytotoxic T cell fate and trafficking. mTORC1 is inhibited by the drug rapamycin which is …
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Serine/threonine phosphorylation in mycobacterium tuberculosis : identification of protein kinase B (PknB) substrates
… this bacterium is poorly understood. PknB is a serine/threonine kinase essential for the in vitro survival of M. tuberculosis and therefore a potential drug target against the bacteria. It is the goal of the current study to elucidate downstream substrates of PknB. We have found that PknB shares …
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Gsk3 Mediates Signaling Upstream of Akt
The phosphatidylinositide 3 kinase (PI3K)/Akt signaling network plays a pivotal role in multiple cellular functions. PI3K links the extracellular growth factor receptors to the serine-threonine kinase Akt which, through phosphorylation of numerous intracellular proteins, mediates increased cell …
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Characterizing the role of p21-Activated Kinase 3 (PAK3) in AP-1-induced transformation
Previous studies identified p21-Activated Kinase 3 (PAK3), a serine/threonine kinase, as a potential AP-1 target gene. PAK3 has been implicated in a variety of pathological disorders and over-expression of other PAK-family members has been linked to cancer. In this study, we investigated AP-1 …
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Purification and characterization of an insulin-stimulated kinase
… by the activation of a number of discreteprotein serine/threonine kinases. The cellular targets of some of these kinases include key metabolic enzymes such as acetyl-CoA carboxylase (ACC) and the ribosomal S6. While, the S6 kinases have now been purified and characterized, very little is known …
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PREPARATION AND EVALUATION OF DECONSTRUCTION ANALOGS OF 7-DEOXYKALAFUNGIN AS AKT INHIBITORS
… recently found to be selective inhibitors of the serine-threonine kinase AKT/PKB. AKT/PKB plays a major role in tumorigenesis, hence these compounds have a great potential to act as anti-cancer agents. They act by a novel bioreductive alkylation mechanism of inhibition of AKT/PKB. In this work, …
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P21- ACTIVATED KINASE 4 AND ACTIN CYTOSKELETON DYNAMICS
P21-ACTIVATED KINASE 4 (PAK4), A SERINE/THREONINE KINASE FROM THE GROUP II PAK FAMILY KINASES, IS ONE OF MANY ACTIN DYNAMICS REGULATORS THAT CONTROL THE FORMATION OF ACTIN-RICH STRUCTURES SUCH AS FILOPODIA IN MAMMALIAN CELLS. PAK4 PHOSPHORYLATES LIM KINASE (LIMK), WHICH IN TURN, PHOSPHORYLATES THE …
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The localization of mTORC1 signaling
… the Target of Rapamycin (TOR) Pathway. TOR is a serine/threonine kinase that resides in two distinct protein complexes which in mammals are referred to as mTORC1 and mTORC2. While significant emphasis has been placed on defining which pathways TOR controls and on how TOR activity is set, less is …
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Strukturbiologie der humanen PIM-1-Kinase
The protein PIM-1 is a serine/threonine kinase which is expressed of the gene pim-1. pim-1 is a proto-oncogene which is implicated in molecular mechanisms of differentiating and proliferation. The cristallography allows to determine the structures of macromolecules. For this the protein kinase …
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ΦΩΣΦΟΡΥΛΙΩΣΗ ΠΡΩΤΕΙΝΩΝ ΣΕ ΣΥΣΤΗΜΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΕΛΕΥΘΕΡΟ ΚΥΤΤΑΡΩΝ ΑΠΟ ΣΥΚΩΤΙΠΟΝΤΙΚΟΥ. ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΜΙΑΣ ΝΕΑΣ ΚΙΝΑΣΗΣ ΠΡΩΤΕΙΝΩΝ ΠΟΥ ΡΥΘΜΙΖΕΤΑΙ ΑΠΟ ΚΥΚΛΙΚΑ ΝΟΥΚΛΕΟΤΙΔΙΑ
… PHOSPHORYLATION IS REPORTED. THE ENZYME IS A SERINE- THREONINE KINASE WITH A MOLECULAR MASS OF 90 KDA. IT CONTAINS A 47 KDA AUTOPHOSPHORYLATABLE PEPTIDE AND CONSEQUENTLY IN ALL PROBABILITY THE NATIVE ENZYME IS A HOMODIMER. IT ACTS OPTIMALLYAT PH 7.5 AND PHOSPHORYLATES HISTONES AND POLYSOMAL …
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Defining the Role of PIM1 in Tumor Angiogenesis
PIM1 is a serine/threonine kinase that is upregulated in cancer. PIM1 is constitutively active upon translation, so protein levels equate to activity. Researchers have connected PIM1 signaling with pro-survival and pro-proliferative roles; however, little is known about how PIM1 is upregulated in …
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Proteomic analysis of the function of DMPK, the myotonic dystrophy protein kinase
… embedded in the 3'UTR of a gene which encodes a serine threonine kinase, DMPK. The precise mechanism by which CTG repeat expansion causes the complex pathology of DM1 is under active investigation. Repeat expansion leads to a failure of transport of DMPK mRNA from nucleus to cytoplasm indicating …
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Akt2 Redox-regulation in Breast Cancer and Diabetes
The serine/threonine kinase, Akt, is a central signaling hub linked to multiple cellular processes. The three mammalian isoforms of Akt (Akt1, Akt2, and Akt3) share common structural and functional characteristics. Despite their common features and shared activation pathway, the Akt isoforms …
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Characterization of a Novel Signaling Motif in the CD3 ε Subunit of the T Cell Receptor
… that this motif uniquely interacted with the serine/threonine kinase, G protein-coupled receptor kinase 2 (GRK2). Interactions between the BRS and GRK2 contribute to the ability of the TCR to cross talk with G protein-coupled receptors, such as CXCR4. The BRS was also capable of mediating …
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Photosensing with LOV: Molecular Insights into the Shared Mechanism of Light-Regulated Kinase Signaling between Plant Phototropins and Bacterial Two-Component Systems
… on characterizing the role of LOV domains in kinase signaling and the mechanism of signal propagation from LOV domains to a diverse set of downstream effectors. I started from the studies of the LOV domain regulated serine/threonine kinase activity from plant phototropins, later comparing this …
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LKB1, CCL2, and Macrophages: A New Axis of Endometrial Cancer Progression
… that have progressed beyond the uterus. The serine-threonine kinase LKB1 has been identified as a potent suppressor of uterine cancer. Combined genetic, proteomic, and in vivo studies in genetically engineered mouse models show that loss of LKB1 protein is associated with high grade, high …
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Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
Akt1 (protein kinase B), a serine/threonine kinase, has emerged as a critical molecule in signal transduction pathways involved in cell proliferation, growth, survival, apoptosis and glucose metabolism. A previous study has shown that transplanted human neural stem cells (hNSCs) selectively migrate …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… regulation of EZH2 activity by tumor suppressor kinase is not well understood. Glycogen synthase kinase 3 beta (GSK3b), a multifunctional serine/threonine kinase, is involved in many cellular processes. GSK3b also participates in neoplastic transformation, tumor development and regulate cancer …
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