Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"serine protease inhibitors."”.
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The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection
… 9 (PI-9/ serpinB9) and the murine orthologue, serine proteinase inhibitor 6 (SPI-6/ serpinb9) are members of a family of intracellular serine proteinase inhibitors (serpins). PI-9 and SPI-6 expression in immune-privileged cells, antigen-presenting cells, and cytotoxic T cells protects these …
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Engineering of the microviridin post-translational modification enzymes for the production of synthetic protease inhibitors
… lactone and lactam rings, and their activity as serine protease inhibitors. The generalities of their biosynthetic pathway have already been described, however, the lack of information on details such as the protease responsible for cleaving off the leader peptide from the cyclic core peptide has …
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Identification and bioactivity evaluation of an amphibian skin Bowman-Birk-like trypsin inhibitor from Hylarana nigrovittata
… infections. Among these bioactive compounds, serine protease inhibitors have been found in amphibian skin. Serine proteases are a large family of conserved, proteolytic enzymes. They play a role in many bodily functions and some are digestive enzymes. Protease action can be controlled by …
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QUB-1904: A Bioactive Peptide from the Frog Skin Secretion of Pelophylax esculentus
Bowman-Birk type proteinase inhibitors (BBIs) is a typical family of canonical serine protease inhibitors specially derived from plants which can inhibit serine proteases, like trypsin and chymotrypsin. BBIs have various functions, such as for suppress cancer cell proliferation and decrease …
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Biosynthesis of Cucurbita maxima trypsin inhibitor I in the methylophic yeast Pichia pastoris
Squash inhibitors are the smallest natural serine protease inhibitors. Their compact, rigid nature has enabled detailed examination of their 3D structure by NMR and X-ray crystallography. Being of a convenient size to synthesise chemically, the effects on activity of selective substitutions and …
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The penetration protease of the cercariae of Schistosoma mansoni
This thesis is concerned with a study of the proteases released by the cercariae of Schistosoma mansoni while penetrating mammalian skin. The proteases present in secretions collected from the preacetabular glands of cercariae were shown to be active against ¹²⁵I-labelled fibrin but not against …
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Biosynthesis of Cucurbita maxima trypsin inhibitor I in the methylotropic yeast Pichia pastoris
Squash inhibitors are the smallest natural serine protease inhibitors. Their compact, rigid nature has enabled detailed examination of their 3D structure by NMR and X-ray crystallography. Being of a convenient size to synthesise chemically, the effects on activity of selective substitutions and …
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Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins
Serine protease inhibitors (Serpins) are involved in the pathogenesis of neurodegenerative dementia, including the two most common types, Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). The pathological characteristics of AD include senile plaques, mainly composed of aggregated …
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Elucidation of the reaction mechanisms involved in the catalysis mediated by glutamine synthetase in Escherichia coli
… or NH3, is by switching between two putative serine protease-like catalytic triads. Site-directed mutagenesis of a number of residues identiï¬ ed as playing a role in these catalytic triads, led to the following observations. Both Ser52 and Ser53 were important for the catalytic activity of …
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Isolation and characterization of starch, starch biosynthetic genes and protease inhibitors from Marama beab (Tylosema Esculentum)
… marama starch biosynthesis genes and detect serine protease inhibitor activities in green and mature marama seeds. The total starch content of marama bean tubers was determined by amyloglucosidase/α-amylase enzymatic digestion and amylose content by Concanavalin A precipitation. A …
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Development of Methods for Measuring Protein C Inhibitor and Antithrombin: Use of Monoclonal Antibodies against the Reactive Center Loop-Inserted Forms of the Serpins
… C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result …
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Towards development of new strategies for inhibiting skin cancer progression
… progression, such as the overexpression of serine protease inhibitors (serpins). Vaspin (also known as visceral adipose tissue-derived serpin; serpinA12) is the most recently identified serpin. Vaspin is expressed in the skin epidermis, its expression is dysregulated in psoriatic skin, but …
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Synthesis of Novel Chiral Heterocyclic Compounds for Antibacterial Agents and Peptidomimetics
… algae, which display inhibitory activity against serine proteases such as thrombin, trypsin, and factor VIIa. Most aeruginosins contain an heterocyclic moiety called the 2-carboxy-6-hydroxyoctahydroindole (Choi) ring; this Choi moiety is a rigid bicyclic unnatural amino acid and is the core …
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Identification of SPINK2 as biomarker of primary chemoresistance in acute myeloid leukemia and its biochemical role in normal bone marrow.
… appartenente alla famiglia SPINK (Serine Protease Inhibitor Kazal-type). SPINK2 è tipicamente noto come inibitore dell’attivazione prematura dell’acrosina nello spermatozoo; tuttavia, in questo lavoro di tesi tramite analisi di single-cell RNA-seq sono stati rilevati alti livelli …
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Synthesis of chiral intermediates by deritivization of monosaccharides
… core structure. Aeruginosins are tetra peptide serine protease inhibitors isolated from marine sponges and cyanobacterial water blooms. Rigid bicyclic amino acid(Choi)is an essential core structure, which strongly influences biological activity of aeruginosin family members. Aeruginosins showed …