Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"serine metabolism"”.
-
Abrogation of serine metabolism exacerbates intestinal epithelial inflammation via C/EBPβ-NF-κB pathway
… dysregulation in the intestinal epithelium. Serine, a non-essential amino acid synthesized via the rate-limiting enzyme phosphoglycerate dehydrogenase (PHGDH), maintains celular redox balance. Serine metabolism is upregulated in cancer and immune cells, supporting survival and growth. Our …
-
Serine Metabolism Leverages the Integrated Stress Response to Direct Stem Cell Fate During Tissue Regeneration
… Here, I uncover the non-essential amino acid serine as a surprising regulator in this process. Utilizing dietary intervention and HFSC-specific loss-of-function studies, I demonstrate that under serine-depleted conditions HFSCs delay hair growth. Upon injury, serine-restricted HFSCs skew their …
-
Surguvant inflammation and metabolism in colorectal surgery
… (POI) and altered cellular and systemic metabolism in the perioperative period may predispose to colon cancer recurrence. This thesis examined the ability to harness perioperative body composition, cell free DNA (cfDNA) and metabolomic data and apply these as prognostic markers and …
-
Metabolic Coordination of Stem Cell Fate Controls Tumor Initiation and Tissue Repair
… on tumor initiation, I find oncogenic EpdSCs are serine auxotrophs, whose growth and self-renewal require abundant exogenous serine. When extracellular serine is limited in vitro and in vivo, EpdSCs activate de novo serine synthesis, which in turn produces the metabolite α-ketoglutarate (αKG). αKG …