Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"sequence variability"”.
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Development and application of Helicobacter pylori surveillance to improve antimicrobial treatment
… primer PCR to be the most sensitive approach. Sequence analysis of 16S rDNA in tetracycline resistant isolates identified the A926g mutation for the first time from a UK H. pylori isolate and a novel A926C mutation. The mechanism of unstable amoxicillin resistance was investigated. Novel …
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Mutation Rate Analysis of the Human Mitochondrial D-loop and its Implications for Forensic Identity Testing
To further facilitate mitochondrial DNA (mtDNA) sequence analysis for human identity testing, a better understanding of its mutation rate is needed. Prior to the middle 1990's the mutation rate applied to a forensic or evolutionary analysis was determined by phylogenetic means, This method involved …
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The ecology, life history, and phylogeny of the marine thecate heterotrophic dinoflagellates Protoperidinium and Diplopsalidaceae (Dinophyceae)
… based on thecal plate shape. LSU rDNA gene sequences are frequently used to infer the phylogeny of organisms. The many copies of the LSU rDNA found in the genome are thought to be kept homogenous by concerted evolution. In Protoperidinium species, however, there was high intragenomic …
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Investigating the organisation and function of the membrane proteins of the Type VII secretion system in <i>Staphylococcus aureus</i>
… into four variants (EssC1-EssC4) that have sequence variability in their C-terminal domains. These variants are associated with unique clusters of candidate substrate-encoding genes. Here it was shown that each EssC variant can interact with the remaining Ess components from strain RN6390 to …
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Extent of genotype-specific humoral immunity produced on infection with hepatitis C virus: relevance for serological screening and diagnosis
… screening ELISA tests are based upon genotype 1 sequence. Six distinct HCV genotypes exist, which show approximately 30 % amino acid sequence divergence in their encoded proteins. Sequence variability is not uniform across the genome, being greatest in the regions encoding envelope proteins and …
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Applying effectoromics and genomics to identify resistance against <i>Rhynchosporium commune</i> in barley
… genes are likely to be more durable and as a consequence, the discovery of novel <i>R. commune Avr</i> genes is fundamental for the implementation of an integrated pest management approach to prevent this disease.<br/>Recent sequencing of the<i> R. commune</i> genome allowed identification of …
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Molecular Pathogenesis and Development of a Genetically Engineered Vaccine for Type-2 Porcine Circovirus
… pathogenic PCV2 share only about 76% nucleotide sequence identity but have similar genomic organization. The highest sequence variability among PCV isolates is found in the immunogenic ORF2 capsid gene. Based on the sequence data in this dissertation, a universal polymerase chain …
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Streptococcal M protein and human C4BP
… thesis. C4BP-binding HVRs exhibit remarkable sequence divergence, yet bind the same ligand. In the first study, we found that such HVRs can be studied in isolated form, as synthetic peptides, thus allowing us to directly characterize the HVRs and their interaction with C4BP. Our data indicate …
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Understanding the Role of the Hypervariable Region in the Open Reading Frame 1 of the Hepatitis E virus in Viral Replication
… and virion production in vitro. Extensive sequence variability in the HVR among HEV strains of different genotypes prompted us to study the dispensability of this region. Initially we constructed two partial deletion mutants of genotype 1 human HEV, hHVRd1 and hHVRd2, with in-frame deletion …