Global ETD Search
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Showing 1 to 5 of 5 for “"sequence specific binding"”.
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Structural and Functional Studies of ASCC1 in DNA and RNA Alkylation Damage Response
… two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with splicing, transcriptional regulation, and translational control) and two-histidine phosphodiesterase (PDE) (associated with hydrolysis of cyclic nucleotide phosphate bonds). Germline mutations link ASCC1 loss …
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Computational regulatory genomics : motifs, networks, and dynamics
… of life, is largely mediated through the sequence specific binding of regulators. The short, degenerate nature of the recognized elements and the unknown rules through which they interact makes deciphering gene regulation a significant challenge. In this thesis, we utilize comparative …
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Genetic and biochemical interactions between the DNA replication initiator and a chromosome architecture protein in Bacillus subtilis
… with these regions was dependent on Rok. The DNA-binding domain of DnaA was dispensable for association of DnaA with these chromosomal regions. This indirect Rok-dependent association contrasted with the canonical sequence-specific binding of DnaA to eight chromosomal regions containing clusters …
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DNA structural selectivity of binding by the Pol I DNA polymerases from Escherichia coli and Thermus aquaticus
… for this enzyme <I>in vivo</I>. Due to their sequence and structural similarities, Klenow and Klentaq, the “large fragments” of the Pol I DNA polymerases from <I>Escherichia coli</I> and <I>Thermus aquaticus</I>, are considered functional homologues. Klentaq, however, does not have a …
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Aufbau nanoskopischer Netzwerke aus DNA und Bindeproteinen
Zusammenfassung Die vorliegende Arbeit beschäftigt sich mit Grundlagenuntersuchungen zum Aufbau von nanoskopischen Netzwerken aus DNA. Dabei werden zwei Wege verfolgt: Das Stempeln von DNA-Molekülen auf ein Substrat und die Herstellung von Verknüpfungen aus DNA mit Hilfe von Bindeproteinen. …