Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"sequence similarity network"”.
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Assessing the Role of Clusters Derived from Large Sequence Similarity Networks for Gene Function Predictions
… efforts have resulted in a massive inflow of raw sequence data. This raw data, when appropriately processed and analyzed, can provide insight to a trained biologist and aid in hypothesis-driven research. Given the time and resource requirements necessary for biological experiments, computational …
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Structure and function of the terpene biosynthesis enzyme, IspH
… of IspHs from various organisms. Using a sequence similarity network we found that some IspHs form ""Rosetta-stone"" fusion proteins with either the ribosomal protein S1 (RPS1), or a UbiA (4-hydroxybenzoate octaprenyltransferase)-like protein. These fusion proteins are all from obligately …
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Functional discovery in the oxidative D-galacturonate assimilation pathway and development of the enzyme similarity web tool
… is confronted with exponentially growing sequence databases in which roughly half of the entries are either annotated incorrectly or not at all. Therefore, in order to realize the true potential of the data being generated by sequencing projects, something must be done about the way the …
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ISPH fusion proteins, ISPH inhibition, and bisphosphonate mechanism of action
… analysis of the IspH protein family. ~400 sequences out of ~15,000 total sequences in a sequence similarity network of the IspH family were roughly double the length of a typical IspH protein. Most of these sequences contain an IspH domain fused to a RPS1 domain, and most are from obligate …
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Characterization of Cyclopropyl Synthases Involved in the Maturation of Ribosomally Synthesized and Posttranslationally Modified Peptides
<p>Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products with significant human health implications. RiPPs are synthesized from a genetically encoded precursor peptide that undergoes significant modifications by maturing enzymes, or …