Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"sequence recognition"”.
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A computer algebra package for polynomial sequence recognition
… for the intelligent guessing of polynomial sequence formulas based on user-defined expected sequence factors of the input coefficients. We present a specialized hybrid approach to finding exact representations for polynomial sequences that is motivated by the need for an automated procedures …
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Numerical Sequence Recognition: Is Familiarity or Ordinality the Primary Factor in Performance?
… of ordinal association in 3-digit numerical sequences is a primary factor in the speed and accuracy with which people recognize numerical sequences. Using two experiments I examined an alternative hypothesis, specifically that having automatic access to a larger set of memorized (i.e., …
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The development of a nanoscale Coulter counter for rapid genetic sequence recognition
… direct electrical detection of specific genetic sequences of deoxyribonucleic acid (DNA); the general approach used to accomplish sequence recognition is a refinement of the resistive pulse technique. Commercial Coulter counters fabricated with sub-micrometer apertures can size particles with …
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DEEP ARCHITECTURES FOR SPATIO-TEMPORAL SEQUENCE RECOGNITION WITH APPLICATIONS IN AUTOMATIC SEIZURE DETECTION
… significant improvements in performance for sequence recognitions tasks for temporal signals such as speech and for image analysis applications that can exploit spatial correlations, and for which large amounts of training data exists. The primary goal of our proposed research is to develop …
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Studies of sequence recognition by the EcoRI restriction/modification system of Escherichia coli
Sequence recognition by the EcoRI restriction/modification system of Escherichia coli is currently the subject of intense study as a model of the general phenomenon of target location by nucleotide sequence-specific enzymes and binding proteins. Models have proposed a variety of means for site …
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Precise and expansive genomic positioning for CRISPR edits
… threats. This straight-forward RNA-programmed sequence recognition by CRISPR has facilitated its rapid global impact on genetic research, diagnostics, therapeutics, and bioproduction. An ideal DNA-editing platform would achieve perfect accuracy on any desired cellular and genomic target. CRISPR …
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TB-RBP protein : sitting at the crossroads of sex and disease
… a DNA-binding protein that binds to specific DNA sequences at breakpoint junctions of chromosomal translocations of lymphoid malignancies. Trax, structural homologue of TB-RBP, has already been shown to interact with the single stranded DNA -/RNA - binding protein TB-RBP. Co-crystallization of …
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Novel DNA probes for sensitive DNA detection
The ability to detect and interrogate DNA sequences allows further understanding and<br/>diagnosis of genetic disease. The ability to perform such analysis of genetic material<br/>requires highly selective and reliable technologies. Furthermore techniques which can use<br/>simple and cheap …
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Novel nucleotide analogues for forming stable DNA triple helices
… (TFO) to a DNA duplex, via specific recognition of the individual base pairs in the target sequence.<br/>Mixed-sequence recognition of duplex DNA by TFOs is therefore an essential requirement for successful targeting. However, achieving strong, yet specific binding to the …
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Calling Cards For DNA-Binding Proteins
… factors, which bind to specific DNA sequences near genes. In order to understand the regulatory networks that control transcription, the genomic targets of all transcription factors under various conditions and in different cell types must be identified. This remains a distant goal, …
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A versatile protein platform for sequence specific nucleic acid detection
… applications, and establish direct link between sequence recognition and signal generation.In this dissertation, I describe the development of a universal platform for sequence-specific nucleic acid imaging and detection based on Transcription Activator-Like Effector (TALE) proteins with …
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Next generation approaches toward engineering therapeutic proteases
… of large mutant libraries. While primary sequence recognition may suffice for proteomic applications, many therapeutic applications of engineered proteases will require the cleavage of folded protein targets. Unfortunately, we have found that engineered proteases that can cleave peptides …
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Study and engineering of nucleic acid-binding repeat proteins
… have evolved repetitive structures and a modular sequence recognition mode. In particular, DNA-binding transcription activator-like effectors (TALE) and RNA-binding Pumilio/fem-3 binding factor homology (PUF) proteins were shown to bind their target sequences in a single repeat/base fashion. This …
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Recovering from Dormancy: Fixation of CSM6-Inducing Spacers in the Bacterial Population
… loci contain clusters of characteristic repeat sequences separated by short "spacer" sequences which are derived from prior invading genetic material and form the basis of these acquired memories. During an immune response, spacer sequences are transcribed into guide RNAs and will recognize …
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Investigating Genetic (IN)Compatibility Between Temperate Phages and CRISPR-CAS Systems in Staphylococcus Aureus
… genetic elements on the basis of nucleic acid sequence recognition, but do not necessarily discriminate between target elements which are burdensome and those which are beneficial. My thesis is concerned with the consequences of CRISPR-Cas immunity directed at a particular breed of bacterial …