Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"sequence diversity"”.
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Genome composition of Glycine max and sequence diversity among cultivated and exotic accessions
… performed to study soybean genome content and diversity. The first study applied 454 pyrosequencing to obtain a low coverage survey that identifi ed repeat composition of the genome. The second study compiled data from numerous small RNA sequence datasets to follow the small RNA level …
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Comparative Mitochondrial DNA Sequence Diversity in Isolated and Open Populations of Southern Flying Squirrels
… hypervariable region of mitochondrial DNA was sequenced in individuals from each population. Individuals and populations were compared to assess relatedness. Higher sequence diversity was detected in the open and island populations. One island individual shared characters with both the island …
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HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations
… design difficult. We examined HIV-1 subtype C diversity and how it relates to CTL epitope location along viral gag sequences. We found a negative correlation between codon sites under positive selection and epitope regions; suggesting epitope regions are evolutionarily conserved. It is possible …
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Mitochondrial DNA Sequence Variation in Populations of the Nine-Banded Armadillo (Dasypus novemcinctus)
… Arkansas and central Texas). A 233 basepair sequence of the D-loop region of mitochondrial DNA was sequenced in individuals from each population. Individuals and populations were compared to assess relatedness among populations and individuals. Higher sequence diversity was detected in the …
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Evolution of the African Tigerfish (Genus Hydrocynus) : phylogeographic insights into drainage evolution
… methods. In this study, the mitochondrial DNA sequence diversity of the characiform genus, Hydrocynus, which is widespread across tropical Africa, is reconstructed using a phylogenetic framework and divergences are dated using the cytochrome b (cyt) region.
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GENETIC DIVERSITY AND LINKAGE DISEQUILIBRIUM IN WILD SOYBEAN, LANDRACES, ANCESTRAL, AND ELITE SOYBEAN POPULATIONS
… can impact populations by reducing genome diversity and increasing the extent of linkage disequilibrium (LD). To understand the impact of these genetic bottlenecks and selection on sequence diversity and LD within soybean [Glycine max (L.) Merr.], 111 genes and three chromosomal regions …
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Engineering of HIV gp120 by yeast surface display for neutralizing antibody characterization and immunogen design
The sequence diversity of glycoprotein gp120 of the envelope spike of Human Immunodeficiency Virus (HIV) allows the virus to escape from antibody selection pressure. Certain conserved epitopes, like the CD4 binding site, are required for viral fitness and antibodies against these epitopes are able …
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Transcriptomics-Guided Biodiscovery of Peroxidases from Macroalgae
… Marine macroalgae, due to their phylogenetic diversity and ecological adaptations, represent a promising and largely untapped source of novel biocatalysts. The aim of this work was the transcriptomics-guided identification and characterization of novel enzymes, particularly peroxidases, from …
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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag
… resource-limited sub-Saharan Africa. The immense sequence diversity of HIV-1, even within subtypes, makes it challenging to develop effective vaccines that target a wide range of HIV subtypes. Mosaic immunogens have been computationally designed to specifically overcome this hurdle by maximizing …
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Molecular Breeding of Porcine Circovirus Type 2 by Synthetic DNA Shuffling
… PCV2 viruses with an ORF2 displaying genetic diversity from all PCV2 genotypes by synthetic DNA shuffling. Variation was identified at 55 amino acid positions in the ORF2 gene among 853 PCV2 capsid gene sequences available in the GenBank database. Degenerate oligonucleotide primers spanning …
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Isoprene Degradation in the Terrestrial Environment
… chromosome of closely related species. IsoA gene sequence diversity was larger than in previous studies, and the isoA gene sequences were not correlated to the 16S rRNA gene sequences, which could indicate horizontal gene transfer. Isoprene-degrading bacteria were present on a variety of leaves; …
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Plant virus detection and diversity in a mixed tree fruit orchard determined through metagenomic-based analysis of honeybee (Apis mellifera) collected samples
… extracted from bee-related samples, plant virus diversity was profiled at Agriculture and Agrifood Canada (AAFC) Jordan Farm; a long-term mixed tree fruit production orchard in Jordan, Ontario, containing tree fruit species including apricots (Prunus armeniaca), cherries (Prunus avium), peaches …
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The Heme -Copper Oxidoreductase Superfamily: Genomics and Structural Analyses
In this work we characterize the sequence diversity of the heme-copper oxidoreductase superfamily by analyzing over 1100 microbial genomes (Bacteria and Archaea) and nine microbial environmental metagenomic datasets. Over 2000 new putative members were found which we classify into eight oxygen …
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Characterization of Ortho-Succinylbenzoate Synthase (Osbs): A Study of Mechanism, Proficiency and Evolutionary Diversity
… have been identified and their pairwise sequence homology is often as low as 14%. The sequence divergence has allowed us to explore enzymes with different sequences that catalyze the same reaction, thus providing insight into evolutionary paths used within the enolase superfamily. To …
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Phase Separation Mediated Compartmentalisation of Rotavirus Replication
… factories and reveal how NSP5 phosphorylation, sequence diversity, and RNA features converge to regulate condensate behaviour, genome assembly, and ultimately viral replication.
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Structure function analysis of the deubiquitylating enzyme Fam
… affecting protein fate. USPs exhibit broad sequence diversity except over their catalytic cores and it has been suggested that this sequence variation constitutes their individual substrate-specific binding sites. Fat Facets in Mouse (Fam) is a developmentally regulated USP whose function is …
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The Noncontractile Phage Tail-like Bacterial Killing Nanomachines – Characterizing the Specificity Determinants of the F-Pyocins of Pseudomonas aeruginosa
… strains of Pseudomonas aeruginosa, share strong sequence similarities in the genes encoding the tubular portion, however, notable variability exists in the last six genes at the tail tip complex, collectively designated here as specificity genes. In this study, I differentiated F-pyocins into …
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Recognition Mechanisms of Nuclear Localization and Export Signals
… charge, structural disorder and a weak consensus sequence of an amino-terminal basic or hydrophobic-enriched region followed by a carboxyl-terminal arginine residue separated from a proline and tyrosine residue by two to five residues. The proline-tyrosine nuclear localization signal is also …
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The evolution of self-compatibility and its genetic consequences in Leavenworthia alabamica (Brassicaceae)
… by the nearly complete or complete loss of sequence diversity in all of the independently derived self-compatible taxa of Leavenworthia. Inbreeding depression plays a role in the maintenance of self-incompatibility in L. alabamica, and the spread and fixation of self-compatibility alleles …
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Determinants of Core Shell Dependent Rotavirus Polymerase Activity
… bioinformatics approaches to analyze VP1 and VP2 sequence diversity across many RV strains and identify positional locations of critical amino acid changes within the context of known structural domains and motifs. We next tested how the identified sequence differences influenced VP2-dependent VP1 …
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