Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"sequence design"”.
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Sequence design principles for 3D wireframe DNA origami
DNA is a highly programmable molecule that can be designed to self-assemble into nearly arbitrary 2D and 3D nanoscale structures. DNA origami is a particularly versatile method to achieve complex molecular architectures. However, the rules for designing scaffolded DNA origami have not been …
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Optimal stacking sequence design of stiffened composite panels with cutouts
… development of optimization procedures for the design of laminates. The design of composite structures against buckling presents two major challenges to the structural analyst and designer. First, the problem of laminate stacking sequence design is discrete in nature which complicates the …
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Parallel transmit pulse sequence design for ultra-high field (7T) MRI
… which then gives opportunity to add dynamic pTx sequences with minimal disruption. Additionally, pTx spokes pulses are incorporated into a gradient-echo echo-planar imaging (GRE-EPI) sequence (Chapter 6). A task-based functional-MRI (fMRI) experiment shows that data quality (expressed by temporal …
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A method of sequence design for urban streets evaluated in case studies
Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Architecture, 1963.
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Interpretable and controllable Statistical Inference Models for Protein Structure Prediction and Sequence Design
L'abstract è presente nell'allegato / the abstract is in the attachment
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DNA sequence design of non-orthogonal binding networks, and application to DNA data storage
… DNA-based systems focus on using sets of DNA sequences that are orthogonal to each other, such that each DNA sequence has a dedicated binding partner, its complementary sequence. This design approach reduces the number of interactions that must be considered when predicting how a system will …
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DEVELOPMENT OF VIRTUAL SCREENING METHODOLOGIES FOR IDENTIFYING RNA-BASED THERAPIES
… predicting protein-RNA binding affinities and designing RNA sequences with specific functional outcomes. The research introduces PANTHER (Protein-Affinity for Nucleic Target-binding, Hybridization, and Energy Regression), a novel machine learning-based scoring function that predicts protein-RNA …
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De novo design of protein binders as functional therapeutics
De novo design of protein binding proteins (minibinders) with target structure information alone remains a grand challenge. A general computational design framework includes (1) generation of binder backbones, (2) sequence design and side-chain refinement, (3) resampling, and (4) prediction of …
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Cyclic prefix assisted block transmission for low complexity communication system design
… for low complexity communication system design. Two important aspects are studied: the CP based low-complexity schemes for channel equalization and channel estimation. Specifically, based on the simple frequency domain equalization, a low complexity joint receiver is proposed for CP-CDMA …
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Advances in Magnetic Resonance Phase‐Contrast Velocity Mapping
… Phase unsteadiness in fast phase-contrast sequences and its effect on flow quantitation is analysed and a modification to the sequence design is proposed. In a next step, system imperfections resulting from uncompensated eddy currents are studied using dynamic magnetic field monitoring …
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A Brain-Based Approach To Educational Pedagogy
… research, informs educators’ pedagogical design for students with Autism Spectrum Disorder (ASD). By combining brain-based teaching components, background in the neurology of the brain, and various learning theories, educators were provided filters for making educational decisions. …
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MULTIPLE STRATEGIES IN COMPUTATIONAL PROTEIN DESIGN: STRUCTURAL INTUITION, PROBABILISTIC INVERSE FOLDING, AND GENERATIVE APPROACHES
Designing proteins with specific structural and functional features has become increasingly feasible through the integration of physics-based modeling, statistical inference, and generative algorithms. This work presents conceptual, methodological, and applied examples spanning multiple stages of …
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Information-Based Torsion Angle Potential for Proteins and Applications
… potentials in protein structure prediction and design. As an introduction we survey the aspects and methods involved in the derivation and applicability of various statistical potentials. The statistical potential created in this work is based on a reduced protein representation described by the …
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Design of thermal control systems for testing of electronics
… actual functional test. This thesis covers the design, modeling and testing of two prototype systems. One system uses a low cost IR heating system to preheat bulk devices to a target temperature, prior to the actual functional test. Theory shows that the limits on temperature ramp rates are …
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Clinically relevant magnetic resonance imaging and spectroscopic imaging development
… been implemented and optimized. This involved sequence design and implementation, SAR considerations, parameter adjustments and clinical testing. The method can deliver 3D Tl or T2 weighted brain image with isotropic Imm3 voxel resolution in approximately 10 minutes. The ability to obtain high …
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Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing
… of this thesis, we have constructed a rationally designed antibody library and analysis platform optimized for use with deep sequencing technologies. Libraries of fully defined oligonucleotides encode three complementarity determining regions (CDRs; L3 from the light chain, H2 and H3 from the …
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In silico protein evolution by intelligent design: creating new and improved protein structures
… comprise a miniscule fraction of the theoretical sequence-structure space that polypeptides might occupy. The goal of protein design is to identify new free-energy minima in this sequence-structure landscape so as to expand the functional repertoire of polypeptides beyond that observed in nature. …
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Using sequence data to investigate the functional design of proteins
Understanding which sequence features enable a given protein to perform a specific function is a long-standing challenge in the field of molecular biology. In particular, the detection of functional specificity among paralogous proteins is challenging, since their common molecular origin causes …
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High resolution magnetic resonance spectroscopic imaging of the brain from 3T to 7T
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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