Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 380 for “"sequence data"”.
-
Unsupervised inference methods for protein sequence data
L'abstract è presente nell'allegato / the abstract is in the attachment
-
Predicting the beta-trefoil fold from protein sequence data
… that uses [beta]-strand interactions at both the sequence and the atomic level, to predict the beta-structural motifs in protein sequences. A program called Wrap-and-Pack implements this method, and is shown to recognize β-trefoils, an important class of globular β-structures, in the Protein Data …
-
Using sequence data to investigate the functional design of proteins
Understanding which sequence features enable a given protein to perform a specific function is a long-standing challenge in the field of molecular biology. In particular, the detection of functional specificity among paralogous proteins is challenging, since their common molecular origin causes …
-
Inferring Determinants of Viral Transmission using Short-Read Sequence Data
… into viral transmission events based upon genome sequence data collected before and after transmission. Previous attempts at bottleneck estimation have neglected the underlying genetic structure of viruses, considering instead less informative single-locus statistics. Here I examine the problem of …
-
Predicting the triple beta-spiral fold from primary sequence data
… to discover new instances of the fold in protein sequence databases. In Chapter 2, we present a series of sequence-based methods for the discovery of the fold. The final method in this Chapter is an iterative profile-based search that outperforms existing sequence-based algorithms. In Chapter 3, …
-
FITSL : a language for directed exploration and analysis of sequence data
This thesis describes a sequence-data processing toolkit for analysis of Intelligent Tutoring System (ITS) log data, that unlike other tools allows directed exploration of sequence patterns. This system provides a powerful yet straightforward abstraction for sequence-data processing, and a set of …
-
Identification of Genetic Copy Number Variants in Neurodevelopmental Disorders from Genome Sequence Data
… identify CNVs from whole exome or whole genome sequence reads. However, there are no established best practices for CNV detection, and the use in molecular diagnostics is not routine. This thesis aimed to establish a bioinformatic framework for the identification of causative CNVs from aligned …
-
Characterisation of the Ugandan HIV epidemic with full-length genome sequence data from 1986 to 2016
Presented here are two large Ugandan HIV genome datasets, one from the modern period (by the MRC/UVRI & LSHTM group and PANGEA), and another generated from stored 1986 serum samples using target-capture next generation sequencing. Uganda uniquely has two HIV subtypes at similar proportions, and …
-
On the use of locality aware distributed hash tables for homology searches over voluminous biological sequence data
… genomic sequencing technology have resulted in a data deluge in biology and bioinformatics. This increase in data volumes has introduced computational challenges for frequently performed sequence analytics routines such as DNA and protein homology searches; these must also preferably be done in …
-
Host-Microbe Relations: A Phylogenomics-Driven Bioinformatic Approach to the Characterization of Microbial DNA from Heterogeneous Sequence Data
… surprise that when the genome of a eukaryote is sequenced, a medley of bacterial sequences are produced as well. These sequences can be highly informative about the interactions between the eukaryote and its bacterial cohorts; unfortunately, they often comprise a vanishingly small constituent …
-
Assessment of species boundaries of the Moringa Ovalifolia (Dinter & A. Berger) in Namibia using nuclear its DNA sequence data
… the nuclear Internal Transcribed Spacer (ITS) sequenced data analysis. A total of seventeen (17) edited sequences of M. ovalifolia together with thirteen (13) other sequences of Moringa retrieved from NCBI were used to construct phylogenetic trees in Molecular Evolutionary Genetic Analysis …
-
Identification of potential constitutive and tissue-specific promoters and regulatory motifs in Glycine max through datamining of publicly available sequence data
… was performed on publicly available soybean EST data, deposited in the NCBI UniGene database, combined with the soybean genome sequence. EST libraries were grouped based on the tissue they were created from. Grouped libraries were selectively filtered to find constitutive, leaf-preferential (not …
-
The Systemic Response to Fire Damage in Tomato Plants: A Case Study in the Development of Methods for Gene Expression Analysis Using Sequence Data
… of methods for gene expression analysis using sequence data was necessary. This involved developing methods for identifying contamination in DNA sequence data (Chapter 2), identifying over 78,000 false sequences in GenBank and several thousand more in the indica rice genome (Chapter 2), …
-
A molecular phylogeny of the subfamily Arundinoideae (Poaceae)
… or unknown. Because morphological and anatomical data have, to date, been unable to elucidate relationships among these genera, sequence data from two chloroplast genes are used to elucidate relationships among 33 arundinoid genera. Sequence data from the variable, grass-specific insert in the …
-
Delimitating Species Boundaries within the Liomys Pictus- Spectabilis Complex (Rodentia: Heteromyidae)
… on morphological, allozymic and mitochondrial sequence data have indicated that Liomys pictus is paraplyletic relative to L. spectabilis. The purpose of this study was to determine the species boundaries that exist within this complex. I estimated phylogenetic relationships within this complex …
-
An Efficient Primer Selection Process Combining Progressive and Iterative Multiple Sequence Alignment Strategies: ClustalW and HMMER
… algorithm to identify candidate DNA primer sequences. DNA sequencing primers are a critical element of polymerase chain reaction (PCR) and DNA sequence analysis. A variety of methods for deriving DNA primers exist, but such methods are often computationally intensive, or do not use available …
Page 1 of 19