Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"sequence capture"”.
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Sequence capture as a tool to understand the genomic basis for adaptation in angiosperm and gymnosperm trees
… sequencing technologies have allowed trees to be sequenced and used as reference genome, which provided deeper understanding between genotype and environment. Whole genome sequencing is still not possible for organisms having large genomes including most tree species, and it is still not feasible …
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Construction and analysis of the miscanthus genespace
… This complexity necessitates the discovery of sequence variants that distinguish paralogs from alleles, which are most frequent in the low-copy non-coding fraction of the genespace. To enrich for such sequences from Miscanthus genomes, we developed a sequence capture array using a …
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Evaluation of Different Methods for the Detection of Mycobacterium bovis in Lymph Node Tissue
… with the kit, to be correctly identified. Sequence Capture PCR, a known method for the detection of mycobacterial DNA in LN tissue, correctly identified 73.3% of the samples and the remaining 26.7% samples gave false negative results. Both the GenoType Mycobacteria Direct kit and Sequence …
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Population Genetics and Host Specificity of a Rare Parasitic Plant, Cuscuta harperi
… that methods of SNP detection, such as targeted sequence capture, are likely to be superior for identification of polymorphisms in the genome of <em>C. harperi</em>. We also show that host selection by <em>C. harperi</em> is a result of active choice by seedlings and that there are additional …
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Investigation of the genetic components of maternal infanticide in Sus Scrofa
… by our group, were used to design three sequence capture sets in order to study these regions in more detail. The sequencing work was done on a selection of animals grouped in pools, for each line two pools of infanticide animals were selected: animals with an history of infanticide in …
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Adaptive evolution, sex-linkage, and gene conversion in the voltage-gated sodium channels of toxic newts and their snake predators
… in certain snakes. Finally, I use targeted sequence capture to obtain the sodium channel sequences of salamanders and show evidence that tetrodotoxin self-resistance in toxic newts was likely accelerated through gene conversion between resistant and non-resistant sodium channel paralogs. …
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Mechanisms of human papillomavirus and host gene transcriptional deregulation in cervical carcinogenesis
… clones employing the newly developed and unique 'Sequence Capture of Regions Interacting with Bait Loci Hi-C' (SCRiBL-Hi-C) protocol showed that both short- ($~$50 kb), and long-range ($~$1 Mb) interactions occur during the early stages of carcinogenesis. Together, the data in this thesis indicate …
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The Last Stand of Angraecum: Biogeographic and Evolutionary History of Darwin's Muses
… a classification. Using Angiosperms353, a target sequence capture probe set, hundreds of low-copy nuclear genes were sequenced from a broad sampling of <em>Angraecum</em> species across most previously defined sections, along with representatives from associated genera. Phylogenetic analyses …
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Resolving Cell Fate: Experimental, computational and mathematical methods in single cell transcriptomic analysis
Deeper understanding of the embryological origins of tissues and organs is likely to provide insights into novel clinically relevant preventative and therapeutic strategies. To do so effectively and at a large scale so as to have clinical significance requires an exhaustive and meticulously …