Global ETD Search
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Showing 1 to 7 of 7 for “"septins"”.
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Klonierung neuer Spleißformen und Expression des Septins KIAA0202
Septine sind eine neue Untergruppe von GTPasen mit Funktionen in der Zytokinese und in sich-nicht teilenden Zellen, insbesondere Gehirnzellen und Thrombozyten. Septine regulieren Vesikelfusionsereignisse sowohl wärend der Zellteilung als auch bei der Exozytose von Botenstoffen, z.B. Dopamin und …
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Identifizierung neuer Interaktionsproteine des humanen Septins SEPT4 (hCDCrel-2) in fetalem Gehirn
Septine sind eine neue Untergruppe der GTP-bindenden Proteine. Die Septine vermitteln ihre Funktionen als heteropolymere Komplexe. In mitotischen Zellen sind Septine vorwiegend in Zytokinese und in postmitotischen Zellen vor allem in Exozytose involviert. In dieser Doktorarbeit wurden folgende neue …
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Anillin Stabilizes Membrane-cytoskeleton Interactions During Drosophila Male Germ Cell Cytokinesis
… filamentous F-actin, non-muscle myosin II and septins, and in cell culture models has been shown to restrict actomyosin contractility to the cleavage furrow. Whether anillin also serves this function during the incomplete cytokinesis that occurs in developing germ cells has remained unclear. …
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Functional analysis of syp1, a novel substrate of the serine/threonine kinase prk1
… Syp1p colocalizes and physically interacts with septins. Syp1p overexpression disorganizes septin structure and induces the Swe1p-dependent elongated bud phenotype. Syp1p also regulates the organization of septins in different cell cycle stages.
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Characterization of Neuronal Anillin and Borg Protein Localization and Function
Septins are filament-forming proteins that scaffold a host of proteins to their sites offunction. One such protein is anillin, that along with septins, mediates cytokinesis duringcell division. Research to date has focused on characterizing the role of anillin duringcytokinesis. Interestingly, …
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Cell Topology Change by the Physical Engagement of Neighboring Cytoskeletal Networks
… myosin, Dia, anillin, and anillin-recruited septins). Each network has only been studied individually. To understand their dynamics together, I first tracked them in the live embryos. Strikingly, the cap networks expand, meet the segregated actomyosin borders, and then bend downward to coat …
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Hyperosmolality effects on growth and morphology of CHO cells
… several members of the septin protein family. Septins increase the mechanical stability of the cell by interacting with the cellular membrane and probably forming compartments within the cell, which may segregate misfolded proteins from those which still retain their activity and function. This …