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Showing 1 to 14 of 14 for “"septin"”.
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Untersuchung von Septin-Interaktionen
Septine sind eine neue Klasse stark konservierter homologer Proteine, die 1971 in der Hefe Saccharomyces cerevisiae entdeckt wurden. Sie gehören zur Gruppe der GTPasen und sind an Zytokinesevorgängen wesentlich beteiligt. Doch auch in postmitotischen Zellen werden Septine exprimiert, so etwa im …
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Characterization of Neuronal Anillin and Borg Protein Localization and Function
Septins are filament-forming proteins that scaffold a host of proteins to their sites offunction. One such protein is anillin, that along with septins, mediates cytokinesis duringcell division. Research to date has focused on characterizing the role of anillin duringcytokinesis. Interestingly, …
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Regulation of Morphogenetic Events in Saccharomyces cerevisiae
… actin cables are oriented towards that site, and septin filaments assemble into a ring around the polarity site. Several minutes later, the bud emerges. Here, we investigated the mechanisms that regulate the timing of these events at the single cell level and the role of polarisome during …
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Functional analysis of syp1, a novel substrate of the serine/threonine kinase prk1
In budding yeast, the actin and septin cytoskeletons are important for the establishment of cell polarity. During the cell cycle, these cytoskeletons undergo dramatic reorganization which is regulated by many cytoskeleton-associated proteins. In this study, Syp1p has been found to have functional …
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Klonierung neuer Spleißformen und Expression des Septins KIAA0202
Septine sind eine neue Untergruppe von GTPasen mit Funktionen in der Zytokinese und in sich-nicht teilenden Zellen, insbesondere Gehirnzellen und Thrombozyten. Septine regulieren Vesikelfusionsereignisse sowohl wärend der Zellteilung als auch bei der Exozytose von Botenstoffen, z.B. Dopamin und …
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Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA
… knockout cells. Propolin D was unable to enhance septin cage as intracellular S. sonnei formed actin tails in the presence of propolin D; septin cage would restrict formation of actin tails. Geraniol has been shown to target the major virulence regulator, DsbA, which is vital for Shigella's …
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THE ROLE OF PKS1 MEDIATED SECONDARY METABOLISM IN HOST PENETRATION AND COLONIZATION DURING RICE BLAST DISEASE
… ALSO SHOWED DEFECTS IN MELANIN DEPOSITION AND SEPTIN LOCALIZATION. THE ABC3 TRANSPORTER AND A SERINE HYDROLASE FSH1 SHARE THE AFOREMENTIONED GENE CLUSTER WITH PKS1. THESE GENES ARE CO-REGULATED WITH PKS1 AND ARE REQUIRED FOR THE PENETR
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Anillin Stabilizes Membrane-cytoskeleton Interactions During Drosophila Male Germ Cell Cytokinesis
… filamentous F-actin, non-muscle myosin II and septins, and in cell culture models has been shown to restrict actomyosin contractility to the cleavage furrow. Whether anillin also serves this function during the incomplete cytokinesis that occurs in developing germ cells has remained unclear. …
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The Generation of Alternative Transcripts as a Means of Regulating Phosphorylation in Sonic Hedgehog Medulloblastoma
… these, Ring Finger Protein 220 (Rnf220) and Septin-9 (Sept9) emerged as key candidates, with their longer phosphorylated isoforms showing significantly higher expression in MB compared to GNP. At the protein level, the Sept9 long isoform was found to localize preferentially to the periphery …
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COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS
… proteins, such as cytokeratin 8, cytokeratin 19, septin 2, and alpha tropomyosin, are altered in common across the three resistant cell lines. MCF-7 cell lines resistant to etoposide and mitoxantrone are more similar in protein abundance changes. Some of the proteins whose abundances are altered …
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Energy Stress Causes Chaperones to Assemble Into Cytoplasmic Complexes
… it to localize to structures that resemble the septin ring and Gln1 filaments. CFP also caused an apparent cytokinesis defect.</p>
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Hyperosmolality effects on growth and morphology of CHO cells
… Second, cells overexpress several members of the septin protein family. Septins increase the mechanical stability of the cell by interacting with the cellular membrane and probably forming compartments within the cell, which may segregate misfolded proteins from those which still retain their …
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Zur Funktion der Kinase Dyrk1A im Gehirn der adulten Maus
… Sept4 (Pnutl2/H5/CDCrel-2), a GTPase of the Septin family, and Arip4, a steroid hormone receptor cofactor with ATP-dependent chromatin-remodelling activity. These interactions were confirmed in mammalian cells by coimmunoprecipitation. By in situ-hybridisation, the coexpression of Dyrk1A with …
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Proteomic analysis of the sorting machineries involved in vesicular traffic between the biosynthetic and endosomal compartments
… effectors (Big1, ARAP1, AGAP1), members of the septin family involved in actin rearrangements and most of the already described effectors of Rab5 microdomains (EEA1, Rabaptin-5, Rabex-5, Vps45) involved in early endosomal dynamics were selectively recruited together with Rab5 and Rab7. Thus, the …