Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 60 for “"septic shock"”.
-
Septic shock : providing early warnings through multivariate logistic regression models
(cont.) The EWS models were then tested in a forward, casual manner on a random cohort of 500 ICU patients to mimic the patients' stay in the unit. The model with the highest performance achieved a sensitivity of 0.85 and a positive predictive value (PPV) of 0.70. Of the 35 episodes of hypotension …
-
Reducing Mortality from Severe Sepsis and Septic Shock: A Macro System Approach
… Agency for Healthcare Research and Quality ranks septicemia as the number one most expensive condition treated in U.S. hospitals, resulting in aggregate costs of $20.3 billion or 5.2% of the total aggregate cost for all hospitalizations. Starting October 2015, the Centers for Medicare & Medicaid …
-
Engineering the T Cell Receptor to Protect Host Cells in Superantigen-Induced Septic Shock
… potential antagonists to T cells in SE-induced septic shock.
-
The Role of Arginine Vasopressin Receptor 2 in Microvascular Hyperpermeability During Severe Sepsis and Septic Shock
… Results demonstrated that the treatment of septic sheep with tolvaptan, an FDA-approved V2R antagonist, significantly attenuated the sepsis-induced fluid retention and markedly reduced the lung water content. These pathological changes were not affected or augmented by the treatment with V2R …
-
Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study
Septic shock is associated with oxidative stress, reduced levels of plasma vitamin C and stress hyperglycaemia – all factors that may influence endothelial, and therefore, organ function. Vitamin C is an important antioxidant in human plasma; and it has been implicated in maintaining normal …
-
The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock
… surgery on cardiopulmonary bypass (CPB) and in septic shock. prognostic studies of acid-base data for critically ill children in the settings of post-operative cardiogenci shock and septic shock are relatively scarce. It has been suggested that hyperchloraemia migh be a benign phenomenon that …
-
An eICU/ICU Collaborative to Reduce Sepsis Mortality
… to fulfill the 6-hour bundle compliance for septic shock resuscitation. The other technology was the activation and enhancement of the Core Measure Manager (CMM) high-quality data surveillance technology by Sutter’s eICU to screen all patients at Sutter Solano Medical Center for early …
-
Identifying and Assessing Barriers to Meeting Sepsis Guidelines in the Emergency Department at an Urban Academic Medical Center: A Process Analysis
… compliance with the CMS Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) at an urban academic medical center (UAMC) ED. The aims of this project were to assess the current protocol in place for sepsis management and identify barriers to meeting the goals of the CMS SEP-1 …
-
Biomarkers in sepsis and other severe infections
… alterations found in patients with sepsis and septic shock. We identified a protein (Wnt5a) that inhibited differentiation of monocytes to monocyte-derived myeloid dendritic cells (Mo-mDC), which may play a role in the DC depletion often seen in sepsis. Also, as indicated by cell surface …
-
The recognition of lipopolysaccharides present in Gram-negative bacteria by receptors of the immune system
… including a life-threatening condition known as septic shock. Sepsis results in a dysregulated systemic inflammatory immune response with systemic consequences. The function of the immune system requires efficient communication between immune cells and this is achieved partly through specific …
-
Nursing Perspectives and Opinions on Early or Delayed Sepsis Treatment: A Mixed Methods Approach
… hypotension, and death when severe sepsis or septic shock is involved. Sepsis is responsible for 50% of acute kidney injury (AKI), which is the most common form of organ dysfunction seen in critical care. Sepsis associated AKI results in loss of, or decreased renal function, is associated with …
-
HOST DEFENSE PEPTIDES OF THE COAGULATION SYSTEM AND THEIR THERAPEUTIC POTENTIAL
… survival rates in mouse models of LPS-induced septic shock (paper I). Quantitative structure-activity relationship (QSAR) analysis utilizing biophysical, antimicrobial and immunomodulatory activities of peptides derived from evolutionary conserved C-terminal protease domains of serine …
-
Respiratory Tract Infections: Aspects of Aetiology, Virulence, and Communicable Disease Control
… differ regarding their capacity to cause septic shock and, together with age and co-morbidities, have an important impact on outcome. The primary endpoint in our investigation was septic shock, a state produced by the immune system and triggered by the invading microorganism. This …
-
Cortisol perturbation in the pathophysiology of septicaemia, complicated pregnancy and weight loss/obesity.
… pressure. These clinical states include: (1) septic shock, (2) hypertensive disorders of pregnancy and (3) obesity-induced hypertension. Prior to the studies described here, little was know about cortisolaemia in these common pathological states. Septic shock is a life threatening condition …
-
Predicting hyperlactatemia in the ICU
… different risk categories for progressing to septic shock. From arterial blood pressure waveform trends collected from bedside monitors and readily available among patients with an arterial catheter, high-resolution time signals of heart rate and arterial blood pressure measurements, as well …
-
Early Intervention In Suspected Sepsis Patients
… reduce unnecessary deaths related to sepsis and septic shock.</p>
-
Prospective cohort study on thirty day outcome of perforation peritonitis at the University Teaching Hospitals, Lusaka, Zambia
… days. The most common cause of death was septic shock in nineteen (52.78%) followed by sepsis, and acute kidney injury. The predicted morbidity score correlated positively with size of perforation and the POSSUM score, although not statistically significant. Number of perforation, site of …
-
Multivariate sequential contrast pattern mining and prediction models for critical care clinical informatics
… acute hypotension, multiple organ failures, and septic shock events. In the process, we employ novel sequential pattern mining methodologies for the structured analysis of large-scale ICU datasets. The reported algorithms use a discretised representation such as symbolic aggregate approximation …
Page 1 of 3